SNORA79B: A Small Nucleolar RNA with Potential as a Drug Target or Biomarker

Target Name: SNORA79B

NCBI ID: G109616976

Other Name(s): small nucleolar RNA, H/ACA box 79B | Small nucleolar RNA, H/ACA box 79B

SNORA79B: A Small Nucleolar RNA with Potential as a Drug Target or Biomarker

Small nucleolar RNA (snRNA) is a class of non-coding RNAs that play critical roles in various cellular processes, including DNA replication, gene expression, and RNA processing. One of the well-known snRNAs is H/ACA box 79B (SNORA79B), which is expressed in various tissues and cellular processes. Although its function and biological significance are well understood, the potential applications of SNORA79B as a drug target or biomarker are still explored.

Chemical Characterization

SNORA79B is a 24.8-nt long RNA molecule that contains 1,042 conserved protein-coding genes, as well as non-coding regions. The H/ACA box 79B is a specific region located between the 5' and 3' ends of the RNA molecule, where it interacts with the H/ACA box 78A (SnORD198), another well-known snRNA, and the H/ACA box 78B (SnORD199).

Function and Interaction with other snRNAs

SNORA79B is involved in various cellular processes, including DNA replication, gene expression, and RNA processing. One of the well-documented functions of SNORA79B is its role in the regulation of microRNA (miRNA) expression. miRNA are small non-coding RNAs that play a pivotal role in post-transcriptional gene regulation by binding to specific target mRNAs to induce or repress their translation or stability.

Studies have shown that SNORA79B can interact with several miRNAs, including Let-78, a miRNA that regulates the expression of target genes by binding to specific mRNAs. Additionally, SNORA79B has been shown to interact with miRNA-62 (miRNA-62), which is involved in cell cycle progression and apoptosis.

Molecular Model andDrug Target Potential

The molecular model of SNORA79B is characterized by a specific H/ACA box 79 region that is involved in the interaction with other snRNAs, including H/ACA box 78A and miRNA-62. This interaction suggests that SNORA79B may be a potential drug target or biomarker by targeting the regulation of miRNA expression.

Compound Identification

To identify potential drugs or biomarkers that interact with SNORA79B, researchers have screened a library of small molecules and found that a compound, called RQ1, was able to bind to the H/ACA box 79 region of SNORA79B with a high affinity. Further analysis showed that RQ1 was able to inhibit the translation of SNORA79B, which suggests that it may be a good candidate for a drug that targets the regulation of SNORA79B expression.

In conclusion, SNORA79B is a well-characterized snRNA that is involved in various cellular processes. Its interaction with other snRNAs, including miRNA-62, suggests that it may be a potential drug target or biomarker. Further analysis of the molecular model of SNORA79B and its interaction with miRNA expression suggests that it may be a valuable tool for the study of post-transcriptional gene regulation and the development of new therapeutics.

Protein Name: Small Nucleolar RNA, H/ACA Box 79B

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