HS3ST3A1: A Potential Drug Target for Hematological Diseases (G9955)

Target Name: HS3ST3A1

NCBI ID: G9955

HS3ST3A1: A Potential Drug Target for Hematological Diseases

HS3ST3A1, also known as H3-OST-3A, is a protein that is expressed in various tissues throughout the body. It is a key regulator of the hematopoietic stem cell (HSC) lineage and has been identified as a potential drug target in the field of hematological diseases.

The HSC is a specialized type of stem cell that gives rise to all blood cells, including red blood cells, white blood cells, and platelets. HSCs have the ability to self-renew and differentiate into different cell types, making them a promising source of cancer therapies. However, the development and maintenance of HSCs is a complex process that is not fully understood.

HS3ST3A1 is a non-coding RNA molecule that has been shown to regulate the self-renewal and differentiation of HSCs. It is a key regulator of the p53 gene, which is a well-known tumor suppressor gene that plays a critical role in preventing the development and progression of cancer.

studies have shown that HS3ST3A1 can inhibit the self-renewal ability of HSCs by targeting the p53 gene. This can lead to a reduction in the number of HSCs that have the ability to divide and multiply, which can potentially lead to a reduction in the risk of developing cancer.

Additionally, HS3ST3A1 has also been shown to play a role in the regulation of cell survival and the transition of cells to apoptosis. This is important because the regulation of cell survival and apoptosis is a critical aspect of the immune system and has been implicated in a number of diseases, including cancer.

In conclusion, HS3ST3A1 is a protein that has the potential to be a drug target in the field of hematological diseases. Further research is needed to fully understand its role in the regulation of HSCs and its potential as a therapeutic agent.

Protein Name: Heparan Sulfate-glucosamine 3-sulfotransferase 3A1

Functions: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate (PubMed:10520990, PubMed:9988768, PubMed:10608887, PubMed:15304505). Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2 (PubMed:10520990, PubMed:9988768, PubMed:15304505). The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry (PubMed:10520990). Unlike HS3ST1/3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (PubMed:10520990)

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