Target Name: DCX DET1-COP1 ubiquitin ligase complex
NCBI ID: P28708
Other Name(s): None

Unlocking the Potential of the DCX DET1-COP1 Ubiquitin Ligase Complex as a Drug Target or Biomarker

Introduction

The ubiquitin system is a highly conserved protein degradation pathway that plays a crucial role in regulating various cellular processes, including cell division, apoptosis, and signaling pathways. The DCX gene, encoding the protein DET1 (Dynamin-related protein 1), is a key component of the ubiquitin system and has been implicated in numerous cellular processes. The DET1 protein forms a complex with the protein COP1 (Capsellain 1) to create the DCX DET1-COP1 ubiquitin ligase complex. This complex plays a significant role in the regulation of cellular processes, including cell growth, differentiation, and response to various stimuli.

TheDCX DET1-COP1 Complex: Structure and Function

The DCX DET1-COP1 complex is a protein complex that consists of the protein DET1 and the protein COP1. DET1 is a 21-kDa protein that contains a N-terminal domain with a catalytic active site, a central region involved in the ubiquitin-protein interactions, and a C-terminal region that contains a conserved FX domain and a putative G-CS domain. COP1 is a 23-kDa protein that contains a N-terminal domain with a catalytic active site and a C-terminal region that contains a conserved G-CS domain and a unique N-terminal region that is involved in the interaction with DET1.

The DCX DET1-COP1 complex functions as a ubiquitin ligase, where DET1 provides an active site for the ubiquitin chain elongation and COP1 provides a conformational change that optimally connects the target protein to ubiquitin. The DCX DET1 -COP1 complex has been shown to play a role in various cellular processes, including cell growth, differentiation, and response to various stimuli.

DET1-COP1 Ligase Complex: Interactions and Signal Transduction

The DCX DET1-COP1 complex has been shown to interact with various proteins, including other ubiquitin ligases, such as HDTN (HSP70-DNAJ) and UCP2 (Ubiquitin-Conjugated Proteins 2). These interactions play a crucial role in the regulation of the ubiquitin system and in the development of various diseases, including cancer.

In addition to its role in protein-protein interactions, the DCX DET1-COP1 complex is also involved in intracellular signaling pathways. The DET1 protein has been shown to be involved in various signaling pathways, including the regulation of cell growth, differentiation, and the response to various stimuli. The COP1 protein has also been shown to be involved in the regulation of cellular processes, including cell adhesion, migration, and the response to various signaling pathways.

Targeting the DCX DET1-COP1 Complex as a Drug Target

The DCX DET1-COP1 complex has been identified as a potential drug target in various diseases, including cancer. Several studies have shown that the DET1 protein is overexpressed or downregulated in various diseases, including cancer, and that this overexpression or downregulation can lead to the disruption of the ubiquitin system (8,9).

In addition to its potential as a drug target, the DCX DET1-COP1 complex is also a biomarker that can be used to diagnose and monitor various diseases. The DET1 protein has been shown to be involved in various cellular processes, including the regulation of cell growth, differentiation, and the response to various stimuli. The COP1 protein has also been shown to be involved in the regulation of cellular processes, including cell adhesion, migration, and the response to various signaling pathways.

Conclusion

The DCX DET1-COP1 ubiquitin ligase complex is a protein complex that plays a crucial role in the regulation of various cellular processes, including cell growth, differentiation, and response to various stimuli. The DET1 protein provides an active site for the ubiquitin chain elongation and the COP1 protein provides a conformational change that allows it to be in the optimal position, thus forming the DCX DET1-COP1 complex.

The DCX DET1-COP1 complex has been shown to interact with various proteins, including other ubiquitin ligases, and has been involved in various cellular processes, including the regulation of intracellular signaling pathways. As a result, the DCX DET1-COP1 complex is a potential drug target and a biomarker for the diagnosis and monitoring of various diseases.

Although more research is needed, the potential of the DCX DET1-COP1 ubiquitin ligase complex as a drug target and biomarker is clear. Further studies are needed to fully understand its role in the regulation of cellular processes and its potential as a therapeutic approach.

Protein Name: DCX DET1-COP1 Ubiquitin Ligase Complex

More Common Targets

DCX(DCAF15) E3 protein ligase complex | DCXR | DDA1 | DDAH1 | DDAH2 | DDB1 | DDB2 | DDC | DDC-AS1 | DDD core complex | DDHD1 | DDHD2 | DDI1 | DDI2 | DDIAS | DDIT3 | DDIT4 | DDIT4L | DDN | DDO | DDOST | DDR1 | DDR2 | DDRGK1 | DDT | DDTL | DDX1 | DDX10 | DDX11 | DDX11-AS1 | DDX11L1 | DDX11L10 | DDX11L2 | DDX11L8 | DDX11L9 | DDX12P | DDX17 | DDX18 | DDX18P1 | DDX19A | DDX19A-DT | DDX19B | DDX20 | DDX21 | DDX23 | DDX24 | DDX25 | DDX27 | DDX28 | DDX31 | DDX39A | DDX39B | DDX39B-AS1 | DDX3P1 | DDX3X | DDX3Y | DDX4 | DDX41 | DDX42 | DDX43 | DDX46 | DDX47 | DDX49 | DDX5 | DDX50 | DDX50P1 | DDX51 | DDX52 | DDX53 | DDX54 | DDX55 | DDX56 | DDX59 | DDX59-AS1 | DDX6 | DDX60 | DDX60L | DDX6P1 | DEAF1 | Death-associated protein kinase | Decapping Complex | DECR1 | DECR2 | DEDD | DEDD2 | Dedicator of cytokinesis protein | DEF6 | DEF8 | DEFA1 | DEFA10P | DEFA11P | DEFA1B | DEFA3 | DEFA4 | DEFA5 | DEFA6 | DEFA7P | DEFA8P | DEFA9P | DEFB1