Target Name: CDC20-DT
NCBI ID: G105378687
Other Name(s): CDC20 divergent transcript, transcript variant X4 | CDC20-DT variant X2 | CDC20-DT variant X4 | CDC20 divergent transcript | CDC20-DT variant X3 | CDC20-DT variant X5 | CDC20 divergent transcript, transcript variant X3 | CDC20 divergent transcript, transcript variant X2 | CDC20 divergent transcript, transcript variant X5

A Promising Potential Drug Target: CDC20-DT, a Variant of the CD20 Transcript in Chronic Myeloid Leukemia

Introduction

Chronic Myeloid Leukemia (CML) is a type of cancer that affects the bone marrow, where white blood cells called leukemia cells overgrow. The most common cause of CML is the BCR-ABL fusion gene, which results in the production of a Philadelphia with chromosome a translocation of the breakpoint gene (TEL-AML-RET) to the BCR gene. This fusion gene creates a BCR-Abl tyrosine kinase that promotes the proliferation of leukemia cells. Although there are several treatment options available for CML, the lack of effective targeting agents remains a major challenge.

CD20 is a protein that is expressed in various types of hematopoietic cells, including B cells, and is known as the B-cell antigen receptor (BCR) 130. It is a potential drug target for CML because BCR-ABL fusion genes express high levels of CD20. Therefore, targeting the expression and function of CD20 could be a promising strategy for the development of new treatments for CML.

CD20 Variants in CML

CD20 has four splice variants, which are designated as CDC20-DT, CDC20-DN, CDC20-DS, and CDC20-DD. These variants differ in the last exon, which is involved in the formation of a glycylated form of the protein. The splice variants also differ in the presence or absence of a splice acceptor protein, which is necessary for the production of functional RNA.

CDC20-DT is the most abundant splice variant and is expressed in most types of hematopoietic cells, including B cells. It is a glycylated form of CD20 and has been shown to be a good predictor of response to AML therapies.

CDC20-DN is a less abundant splice variant that is expressed in a subset of hematopoietic cells, including natural killer cells and some types of progenitor cells. It is a non-glycylated form of CD20 and has been shown to have a different expression pattern than CDC20-DT.

CDC20-DS is a rare splice variant that is expressed in only a few types of hematopoietic cells, including stem cells and some types of progenitor cells. It is a non-glycylated form of CD20 and has been shown to have a different expression pattern than CDC20-DT and -DN.

CDC20-DD is a rare splice variant that is expressed in only a few types of hematopoietic cells, including stem cells and some types of progenitor cells. It is a non-glycylated form of CD20 and has been shown to have a different expression pattern than CDC20-DT and -DN.

CD20 Expression and Function

CD20 is a glycylated form of the protein that is expressed in various types of hematopoietic cells, including B cells, natural killer cells, and some progenitor cells. It is a B cell antigen receptor (BCR) 130 and is involved in the development and maintenance of hematopoietic stem cells (HSCs) and natural killer cells (NK cells).

CD20 has been shown to play a role in the regulation of hematopoietic stem cell (HSC) proliferation and differentiation. It has been shown to be involved in the

Protein Name: CDC20 Divergent Transcript

More Common Targets

CDC20B | CDC20P1 | CDC23 | CDC25A | CDC25B | CDC25C | CDC26 | CDC27 | CDC27P2 | CDC34 | CDC37 | CDC37L1 | CDC37P1 | CDC40 | CDC42 | CDC42BPA | CDC42BPB | CDC42BPG | CDC42EP1 | CDC42EP2 | CDC42EP3 | CDC42EP4 | CDC42EP5 | CDC42SE1 | CDC42SE2 | CDC45 | CDC5L | CDC5L complex | CDC6 | CDC7 | CDC73 | CDCA2 | CDCA3 | CDCA4 | CDCA4P3 | CDCA5 | CDCA7 | CDCA7L | CDCA8 | CDCP1 | CDCP2 | CDH1 | CDH10 | CDH11 | CDH12 | CDH13 | CDH13-AS2 | CDH15 | CDH16 | CDH17 | CDH18 | CDH19 | CDH2 | CDH20 | CDH22 | CDH23 | CDH24 | CDH26 | CDH3 | CDH4 | CDH5 | CDH6 | CDH7 | CDH8 | CDH9 | CDHR1 | CDHR18P | CDHR2 | CDHR3 | CDHR4 | CDHR5 | CDIN1 | CDIP1 | CDIPT | CDIPTOSP | CDK1 | CDK10 | CDK11A | CDK11B | CDK12 | CDK13 | CDK14 | CDK15 | CDK16 | CDK17 | CDK18 | CDK19 | CDK2 | CDK20 | CDK2AP1 | CDK2AP2 | CDK2AP2P2 | CDK2AP2P3 | CDK3 | CDK4 | CDK5 | CDK5R1 | CDK5R2 | CDK5RAP1 | CDK5RAP2