SLC52A3: A Potential Drug Target and Biomarker for Riboflavin Transporter

Target Name: SLC52A3

NCBI ID: G113278

SLC52A3: A Potential Drug Target and Biomarker for Riboflavin Transporter

Riboflavin (Rb) is a crucial cofactor for various cellular processes, including DNA replication, RNA transcription, and protein synthesis. Riboflavin transporter (SLC52A3) is an essential protein that helps regulate the transport of riboflavin across cell membranes. SLC52A3 has been identified as a potential drug target and biomarker for various diseases, including neurodegenerative disorders, diabetes, and cancer.

SLC52A3 Functions as a Riboflavin Transporter

SLC52A3 is a member of the solute carrier family 52, which includes several other transporters that play a vital role in the transport of various anions and nutrients across cell membranes. SLC52A3 is responsible for the transport of riboflavin (Rb), which is a small molecule that plays a crucial role in various cellular processes.

Riboflavin is a small molecule that is involved in various cellular processes, including DNA replication, RNA transcription, and protein synthesis. It is a essential cofactor for the transfer of electrons during DNA replication and helps maintain the stability of DNA. Riboflavin is also involved in the regulation of cell signaling pathways, including the DNA damage response.

SLC52A3 is a 21-kDa protein that is expressed in various tissues and cells. It is primarily localized to the endoplasmic reticulum (ER) and nuclear membrane. SLC52A3 functions as a transporter by using a unique ATP-binding site to mediate the transport of Rb across cell membranes.

SLC52A3 as a Potential Drug Target

SLC52A3 has been identified as a potential drug target due to its involvement in various cellular processes that are altered in various diseases. One of the primary targets of SLC52A3 is neurodegenerative disorders, which are characterized by the progressive loss of brain cells that can lead to cognitive and motor impairments.

SLC52A3 has been shown to be involved in the regulation of neurotransmitter release from axons, which are the nerve cells that carry signals from the brain to the rest of the body. Studies have shown that SLC52A3 is involved in the regulation of the release of dopamine, a neurotransmitter that is involved in mood, motivation, and movement.

In addition to its involvement in neurodegenerative disorders, SLC52A3 has also been shown to be involved in the regulation of cancer cell growth and metastasis. Studies have shown that SLC52A3 is involved in the regulation of the angiogenesis that is the process by which cancer cells grow and metastasize to other tissues.

SLC52A3 as a Biomarker

SLC52A3 has also been identified as a potential biomarker for various diseases, including neurodegenerative disorders, diabetes, and cancer. One of the primary biomarkers for neurodegenerative disorders is the measurement of SLC52A3 levels in brain tissue, as the loss of SLC52A3 has been observed in various neurodegenerative disorders.

Studies have shown that the levels of SLC52A3 are decreased in the brain tissue of individuals with neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. Additionally, SLC52A3 has been shown to be involved in the regulation of neurotransmitter release from axons, which is a critical function for the diagnosis of neurodegenerative disorders.

SLC52A3 has also been shown to be involved in the regulation of cancer cell growth and metastasis. Studies have shown that SLC52A3 is involved in the regulation of the angiogenesis that is the process by which cancer cells grow and metastasize to other tissues.

Conclusion

SLC52A3 is a protein that is involved in

Protein Name: Solute Carrier Family 52 Member 3

Functions: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism (PubMed:20463145, PubMed:22273710, PubMed:24264046, PubMed:27702554). Humans are unable to synthesize vitamin B2/riboflavin and must obtain it via intestinal absorption (PubMed:20463145)

More Common Targets