PWWP2A: Unlocking The Potential of Insulin Secretion and Cancer Prevention

Target Name: PWWP2A

NCBI ID: G114825

PWWP2A: Unlocking The Potential of Insulin Secretion and Cancer Prevention

PWWP2A (MST101) is a protein that is expressed in various tissues of the body, including the brain, pancreas, and muscle. It is a member of the Williams cyclin family, which is a family of transmembrane proteins that play a critical role in various cellular processes.

One of the functions of PWWP2A is its role in the regulation of insulin secretion from pancreatic beta cells. Beta cells are the cells that produce insulin, a hormone that regulates blood sugar levels. Insulin is released from beta cells in response to changes in blood sugar levels, and PWWP2A plays a key role in the regulation of this process.

In addition to its role in insulin secretion, PWWP2A is also involved in the regulation of a variety of other cellular processes, including the transport of molecules across cell membranes and the regulation of cellular signaling pathways.

PWWP2A has also been shown to play a role in the development and progression of various diseases, including cancer. For example, studies have shown that PWWP2A is often overexpressed in various types of cancer, and that this overexpression is associated with a number of negative cellular consequences, including the development of cancer stem cells.

Despite the potential implications of PWWP2A's involvement in various diseases, it is still not well understood. There are currently few research studies focused on this protein, and much of the research that has been done on PWWP2A is based on its expression in cancer cells.

In conclusion, PWWP2A is a protein that is expressed in various tissues of the body and is involved in a variety of cellular processes. While more research is needed, its potential as a drug target or biomarker is significant.

Protein Name: PWWP Domain Containing 2A

Functions: Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260, PubMed:30327463). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (PubMed:30228260, PubMed:30327463). Plays a role in facilitating transcriptional elongation and repression of spurious transcription initiation through regulation of histone acetylation (By similarity). Essential for proper mitosis progression (PubMed:28645917)

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