LRRC25: A Multi-Functional Protein in Cell Signaling Pathways

Target Name: LRRC25

NCBI ID: G126364

LRRC25: A Multi-Functional Protein in Cell Signaling Pathways

LRRC25, also known as LRP-C028, is a protein that is expressed in a variety of cell types, including monocytes, plasma cells, and epithelial cells. It is a member of the long repetitive protein (LRPP) family and is characterized by its unique structure, which consists of a long amino acid sequence that is repeated multiple times.

LRRC25 is known for its role in the regulation of cell signaling pathways, specifically the TGF-β pathway. TGF-β is a cytokine that plays a critical role in the development and maintenance of tissues, including bone, cartilage, and epithelial tissue. It is a transcription factor that regulates the expression of numerous genes, including those that are involved in cell signaling pathways.

LRRC25 has been shown to play a role in the regulation of TGF-β signaling in various cell types. For example, studies have shown that LRRC25 can inhibit the activity of the TGF-β receptor, which is involved in the regulation of cell growth and differentiation. This suggests that LRRC25 may be a drug target or biomarker for TGF-β-related diseases.

In addition to its role in TGF-β signaling, LRRC25 has also been shown to be involved in the regulation of cell adhesion. Adhesion is the process by which cells stick together to form tissues and organs. LRRC25 has been shown to play a role in the regulation of cell-cell adhesion by regulating the activity of cadherins, which are a type of transmembrane protein that is involved in cell-cell adhesion.

LRRC25 is also known for its role in the regulation of cell signaling pathways related to inflammation. It has been shown to play a role in the regulation of the NF-kappa-B signaling pathway, which is involved in the regulation of inflammation and immune responses.

In conclusion, LRRC25 is a protein that is expressed in a variety of cell types and is involved in the regulation of cell signaling pathways, including TGF-β, adhesion, and inflammation. Its unique structure and multiple functions make it an interesting potential drug target or biomarker for a variety of diseases. Further research is needed to fully understand the role of LRRC25 in cell signaling pathways and its potential as a therapeutic agent.

Protein Name: Leucine Rich Repeat Containing 25

Functions: Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting RIGI for autophagic degradation. Interacts specifically with ISG15-associated RIGI to promote interaction between RIGI and the autophagic cargo receptor p62/SQSTM1 to mediate RIGI degradation via selective autophagy (PubMed:29288164). Also plays a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA

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