RPS12P28: A Promising Drug Target / Biomarker (G100271553)

Target Name: RPS12P28

NCBI ID: G100271553

Other Name(s): ribosomal protein S12 pseudogene 28 | RPS12_14_1532 | Ribosomal protein S12 pseudogene 28

RPS12P28: A Promising Drug Target / Biomarker

The protein RPS12P28 is a key regulator of the RNA polymerase II (RPNII) complex, which is responsible for generating double-stranded RNA (dsRNA) in eukaryotic cells. RPNII is a critical enzyme for gene expression, DNA replication, and repair, and it is involved in the regulation of cellular processes such as cell growth, differentiation, and stress responses. The regulation of RPNII activity is critical for understanding the mechanisms of gene expression and for the development of new therapeutics.

The RPNII complex consists of several subunits, including RPS12, RPS14, RPS16, and RPS20, which are encoded by the genes P09290, P09291, P09292, and P09293, respectively. The RPNII complex plays a central role in the regulation of gene expression by controlling the access to transcription factors and the translation of RNA templates into protein products.

The RPS12P28 protein is a key regulator of the RPNII complex. It is composed of 28 amino acid residues and has a calculated molecular weight of 31 kDa. The RPS12P28 protein is expressed in a variety of cell types, including bacteria, yeast, plants, and animals. It is involved in the regulation of cellular processes such as cell growth, differentiation, and stress responses, and is a potential drug target.

The RPS12P28 protein functions as a negative regulator of RPNII activity. It binds to the active site of RPNII and prevents the auto-activation of RPNII. The RPS12P28 protein has been shown to inhibit the activity of RPNII in cell culture and in live cell experiments.

The RPS12P28 protein is also involved in the regulation of DNA replication. It has been shown to interact with the protein responsible for the initiation of DNA replication, named DNRTAP. The interaction between RPS12P28 and DNRTAP suggests that the RPS12P28 protein may be involved in the regulation of DNA replication.

The RPS12P28 protein is expressed in a variety of cell types and is involved in the regulation of cellular processes such as cell growth, differentiation, and stress responses. It is a potential drug target (4) and may be a biomarker for the treatment of various diseases.

Conclusion

The RPS12P28 protein is a key regulator of the RNA polymerase II (RPNII) complex and is involved in the regulation of cellular processes such as cell growth, differentiation, and stress responses. It is a potential drug target (4) and may be a biomarker for the treatment of various diseases. Further research is needed to fully understand the mechanisms of RPS12P28 function and its potential as a therapeutic target.

Protein Name: Ribosomal Protein S12 Pseudogene 28

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