Target Name: CREM
NCBI ID: G1390
Other Name(s): CREM-2 | CAMP-responsive element modulator (isoform 28) | CAMP-responsive element modulator (isoform 15) | CAMP responsive element modulator, transcript variant 8 | CAMP-responsive element modulator (isoform 25) | CREM theta2-beta | CREM variant 23 | hCREM 2alpha-a | CAMP-responsive element modulator (isoform 22) | CAMP-responsive element modulator (isoform 13) | CAMP-responsive element modulator isoform 30 | CREM variant 14 | CAMP responsive element modulator, transcript variant 20 | Inducible cAMP early repressor | CAMP-responsive element modulator (isoform 1) | CREM variant 1 | CAMP-responsive element modulator (isoform 10) | CREM theta1-beta | CREM variant 27 | CREM variant 22 | inducible cAMP early repressor ICER | CREM variant 28 | CREM 2alpha-b protein | CREM variant 10 | CREM 10 | REM-2 | CREM variant 24 | CAMP responsive element modulator, transcript variant 31 | CAMP-responsive element modulator isoform 24 | CAMP responsive element modulator, transcript variant 27 | CAMP-responsive element modulator (isoform 16) | hCREM 2alpha-b | ICER | ICER1 | CREM variant 5 | CAMP responsive element modulator, transcript variant 6 | CAMP-responsive element modulator (isoform 8) | CAMP responsive element modulator, transcript variant 19 | CAMP responsive element modulator, transcript variant 23 | CREM variant 31 | CREM theta1-tau2-beta | CREM variant 8 | CAMP responsive element modulator, transcript variant 14 | hCREM-2 | CAMP responsive element modulator, transcript variant 5 | CAMP responsive element modulator, transcript variant 30 | hCREM 2beta-a | CAMP-responsive element modulator (isoform 6) | CAMP-responsive element modulator (isoform 14) | CAMP responsive element modulator, transcript variant 1 | CREM theta2-tau2-beta | CAMP-responsive element modulator (isoform 2) | ICER11 | CREM variant 30 | CREM variant 6 | CAMP responsive element modulator, transcript variant 25 | CAMP responsive element modulator, transcript variant 26 | cAMP responsive element modulator | CREM variant 2 | CAMP-responsive element modulator isoform 26 | CAMP responsive element modulator, transcript variant 2 | CAMP responsive element modulator, transcript variant 21 | CREM variant 13 | CAMP responsive element modulator, transcript variant 13 | hCREM 2beta-b | Inducible cAMP early repressor ICER | CREM variant 16 | CAMP responsive element modulator, transcript variant 15 | CREM 22 | CAMP-responsive element modulator (isoform 21) | CAMP-responsive element modulator isoform 27 | cAMP-responsive element modulator | CAMP-responsive element modulator (isoform 4) | CREM variant 20 | CAMP-responsive element modulator (isoform 11) | CAMP responsive element modulator, transcript variant 16 | CREM variant 4 | CREM variant 25 | ICER1 gamma | CREM 2beta-a protein | CREM variant 11 | CAMP-responsive element modulator (isoform 5) | CAMP responsive element modulator, transcript variant 28 | CREM variant 21 | CAMP responsive element modulator, transcript variant 24 | cAMP response element modulator | CREM variant 15 | CAMP-responsive element modulator (isoform 20) | CAMP responsive element modulator, transcript variant 10 | CAMP-responsive element modulator (isoform 31) | CAMP responsive element modulator, transcript variant 7 | CREM variant 26 | CAMP responsive element modulator, transcript variant 4 | CREM variant 7 | CREM variant 19 | CREM_HUMAN | CAMP-responsive element modulator (isoform 19) | CAMP-responsive element modulator (isoform 23) | hCREM type1 alpha | CAMP responsive element modulator, transcript variant 11 | CAMP responsive element modulator, transcript variant 22 | CAMP-responsive element modulator (isoform 7)

CREM-2: A Protein Implicated in Multiple Diseases

CREM (CREM-2) is a protein that is expressed in various tissues of the body, including the brain, heart, lungs, and gastrointestinal tract. It is a member of the family of transcription factors, which are proteins that regulate gene expression.

CREM-2 has been shown to play a role in the development and progression of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. It has also been identified as a potential drug target for several diseases, including cancer and neurodegenerative diseases.

One of the key functions of CREM-2 is its role in cell signaling. It is a transcription factor that can activate the genes of other proteins, which can then cause changes in the way cells behave and function. This can include changes in the structure and function of the cell, as well as the production of specific proteins that can cause diseases.

One of the ways that CREM-2 is involved in cancer is its role in the development of neuroblastomas, which are a type of cancer that starts in the brain or spinal cord. Studies have shown that CREM-2 is often expressed in neuroblastomas, and that inhibiting its activity can lead to a reduction in the growth and spread of these tumors.

CREM-2 is also involved in the development and progression of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. These conditions are characterized by the progressive loss of brain cells, and are often associated with increased levels of CREM-2 in the brain.

In addition to its role in neurodegenerative diseases, CREM-2 has also been shown to be involved in autoimmune disorders. These are conditions in which the immune system attacks the body's own tissues, leading to a range of symptoms and conditions. Studies have shown that CREM-2 is often expressed in the immune cells of individuals with autoimmune disorders, and that inhibiting its activity can lead to a reduction in the symptoms of these conditions.

Overall, CREM-2 is a protein that has been shown to play a role in a wide range of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. As a potential drug target, it is being studied for its potential to treat these conditions, and to create new treatments for a variety of diseases.

Protein Name: CAMP Responsive Element Modulator

Functions: Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550)

More Common Targets

CRH | CRHBP | CRHR1 | CRHR2 | CRIM1 | CRIM1-DT | CRIP1 | CRIP1P1 | CRIP2 | CRIP3 | CRIPAK | CRIPT | CRISP1 | CRISP2 | CRISP3 | CRISPLD1 | CRISPLD2 | CRK | CRKL | CRLF1 | CRLF2 | CRLF3 | CRLS1 | CRMA | CRMP1 | CRNDE | CRNKL1 | CRNN | CROCC | CROCC2 | CROCCP2 | CROCCP3 | CROT | CRP | CRPPA | CRPPA-AS1 | CRTAC1 | CRTAM | CRTAP | CRTC1 | CRTC2 | CRTC3 | CRTC3-AS1 | CRX | CRY1 | CRY2 | CRYAA | CRYAB | CRYBA1 | CRYBA2 | CRYBA4 | CRYBB1 | CRYBB2 | CRYBB2P1 | CRYBB3 | CRYBG1 | CRYBG2 | CRYBG3 | CRYGA | CRYGB | CRYGC | CRYGD | CRYGGP | CRYGN | CRYGS | CRYL1 | CRYM | CRYM-AS1 | Cryptochrome | Crystallin | CRYZ | CRYZL1 | CRYZL2P | CRYZL2P-SEC16B | CS | CSAD | CSAG1 | CSAG2 | CSAG3 | CSAG4 | CSDC2 | CSDE1 | CSE1L | CSF1 | CSF1R | CSF2 | CSF2RA | CSF2RB | CSF2RBP1 | CSF3 | CSF3R | CSGALNACT1 | CSGALNACT2 | CSH1 | CSH2 | CSHL1 | CSK | CSKMT | CSMD1 | CSMD2