Understanding The Role of LDLR3 in Lipoprotein Transport and Disease

Target Name: LDLRAD3

NCBI ID: G143458

Other Name(s): Low-density lipoprotein receptor class A domain-containing protein 3 | Low density lipoprotein receptor class A domain containing 3, transcript variant 1 | LRAD3_HUMAN | LDLR class A domain-containing protein 3 | LDLRAD3 variant 1 | low density lipoprotein receptor class A domain containing 3 | LRAD3

Understanding The Role of LDLR3 in Lipoprotein Transport and Disease

Low-density lipoprotein receptor class A domain-containing protein 3 (LDLR3) is a protein that is expressed in most tissues throughout the body. It is a member of the LDLR family of transmembrane proteins, which are involved in the transport of lipoproteins across cell membranes. In addition to its role in lipoprotein transport, LDLR3 is also involved in cell signaling and has been implicated in a number of diseases, including heart disease, diabetes, and cancer.

The LDLR3 protein is composed of 1,212 amino acids and has a calculated molecular mass of 19.9 kDa. It has a distinct N-terminus that is involved in lipid binding and a C-terminus that is involved in cell signaling. The LDLR3 protein is predominantly expressed in the liver, heart, and skeletal muscles and is also found in other tissues, including the brain, pancreas, and placenta.

The function of LDLR3 is closely tied to its role in lipoprotein transport. Lipoproteins are important for the delivery of dietary cholesterol and other fats to peripheral tissues for energy storage and metabolism. LDLR3 is involved in the recognition and binding of lipoproteins to their receptors on the surface of cells. This process is critical for the efficient delivery of lipoproteins to their intended targets and is a critical step in the development of lipid metabolism.

In addition to its role in lipoprotein transport, LDLR3 is also involved in a number of other cellular processes that are important for maintaining cellular health and homeostasis. For example, LDLR3 has been shown to play a role in cell signaling, particularly in the regulation of inflammation and cellular signaling by oncogens. In addition, LDLR3 has been implicated in the development and progression of a number of diseases, including heart disease, diabetes, and cancer.

One potential drug target for LDLR3 is the use of inhibitors of LDLR3 function, such as small molecules or antibodies, to reduce the levels of LDLR3 in the body and improve cholesterol levels. This approach has been shown to be effective in animal models of several diseases , including heart disease and diabetes.

Another potential biomarker for LDLR3 is the measurement of LDLR3 levels in blood or other body tissues. This can be done using a variety of techniques, including Western blotting, immunofluorescence, or mass spectrometry. The levels of LDLR3 in these tissues can be used to assess the overall expression of LDLR3 and to identify potential targets for further investigation.

In conclusion, LDLR3 is a protein that is involved in a number of important cellular processes and has been implicated in a number of diseases. In addition to its role in lipoprotein transport, LDLR3 is also involved in cell signaling and has been shown to play a role in the development and progression of several diseases. As a result, LDLR3 is a potential drug target and a promising biomarker for a variety of diseases. Further research is needed to fully understand the role of LDLR3 in cellular processes and to develop effective treatments.

Protein Name: Low Density Lipoprotein Receptor Class A Domain Containing 3

Functions: May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production. May regulate ITCH and NEDD4 E3 ligase activity and degradation (PubMed:26854353)

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