LILRA4: Member of ILT-7 Subfamily, Regulator of Immune System and Cytokine Production

Target Name: LILRA4

NCBI ID: G23547

LILRA4: Member of ILT-7 Subfamily, Regulator of Immune System and Cytokine Production

LILRA4 (Long Interleukin-2 Receptor subtype 4) is a protein that is expressed in various tissues throughout the body. It is a member of the interleukin-2 receptor subfamily, which is a family of cytokines and cytokine receptor proteins that play a crucial role in the regulation of immune and inflammatory responses. LILRA4 is one of the proteins that belong to the subfamily of ILT-7, which is a type of cytokine that is expressed in a variety of tissues throughout the body.

The ILT-7 subfamily includes several different proteins, including LILRA4, which is characterized by its ability to bind to the IL-2 receptor. The IL-2 receptor is a protein that is expressed in a variety of tissues throughout the body, including T cells, B cells, and natural killer cells. It is a critical regulator of the immune system, and is involved in the regulation of the proliferation and differentiation of these cells.

LILRA4 is a protein that is expressed in various tissues throughout the body, including the lungs, heart, kidneys, and intestine. It is also expressed in the liver, spleen, and pancreas, among other tissues. LILRA4 is a 21-kDa protein, which means that it has 21 amino acid residues. It has a molecular weight of 22.1 kDa.

One of the key functions of LILRA4 is its ability to bind to the IL-2 receptor. The IL-2 receptor is a protein that is expressed in a variety of tissues throughout the body, including T cells, B cells, and natural killer cells. It is a critical regulator of the immune system, and is involved in the regulation of the proliferation and differentiation of these cells. LILRA4 is able to bind to the IL-2 receptor and to regulate its activity.

In addition to its ability to bind to the IL-2 receptor, LILRA4 is also involved in the regulation of inflammation. It is a potent regulator of the production of pro-inflammatory cytokines, such as TNF-alpha, IL-1, and IL-6. It is able to inhibit the activity of these cytokines and to regulate their production. This helps to prevent excessive inflammation and to maintain a balance between pro-inflammatory and anti-inflammatory processes in the body.

Another function of LILRA4 is its ability to regulate the activity of immune cells. It is able to stimulate the production of immune cells, such as T cells and B cells, and to regulate their proliferation and differentiation. This helps to maintain the diversity and activity of the immune system, which is critical for the protection of the body against a variety of pathogens and threats.

In conclusion, LILRA4 is a protein that is expressed in various tissues throughout the body and is involved in a variety of biological processes. It is a member of the ILT-7 subfamily and is able to bind to the IL-2 receptor and to regulate the activity of immune cells. Further research is needed to fully understand the role of LILRA4 in the regulation of the immune system and other biological processes.

Protein Name: Leukocyte Immunoglobulin Like Receptor A4

Functions: Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades (PubMed:16735691, PubMed:19564354, PubMed:24586760). Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells (PubMed:26172439). Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+) (PubMed:16735691, PubMed:19564354). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells (PubMed:24586760)

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