Unlocking the Potential of LIN7C as a Drug Target and Biomarker

Target Name: LIN7C

NCBI ID: G55327

Unlocking the Potential of LIN7C as a Drug Target and Biomarker

LIN7C, also known as lin-7 homolog C, is a non-coding RNA molecule that plays a critical role in the regulation of cell polarity and cytoskeleton dynamics. LIN7C is a key component of the Crumbs cell polarity complex, which is responsible for the maintenance of the

Protein Name: Lin-7 Homolog C, Crumbs Cell Polarity Complex Component

Functions: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells

More Common Targets