Understanding LIMS2: A Potential Drug Target Or Biomarker (G55679)

Target Name: LIMS2

NCBI ID: G55679

Understanding LIMS2: A Potential Drug Target Or Biomarker

LIMS2 (Leucine-rich repeat-containing introns 2) is a non-coding RNA molecule that has been identified as a potential drug target or biomarker. It is a highly conserved non-coding RNA molecule that is found in various cell types, including muscle, heart, and brain cells. LIMS2 has been shown to play a role in the regulation of gene expression and has been linked to a number of diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

One of the unique features of LIMS2 is its ability to interact with other non-coding RNA molecules, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). This interaction between LIMS2 and other non-coding RNA molecules has been shown to play a role in the regulation of gene expression and the development of various diseases.

In addition to its role in gene regulation, LIMS2 has also been shown to play a role in the regulation of protein synthesis. It has been shown to interact with the protein translation factor eIF4F and has been shown to play a role in the regulation of eIF4F-mediated protein synthesis. This interaction between LIMS2 and eIF4F has been shown to contribute to the regulation of cellular processes such as cell growth, apoptosis, and translation.

Another unique feature of LIMS2 is its ability to interact with the protein heat shock factor HSF1. This interaction between LIMS2 and HSF1 has been shown to play a role in the regulation of gene expression and the expression of stress-responsive genes. It has been shown that HSF1 can induce the expression of stress-responsive genes, including LIMS2, through a mechanism known as HSF1-mediated transcriptional repression.

In addition to its role in gene regulation and protein synthesis, LIMS2 has also been shown to play a role in the regulation of cellular signaling pathways. It has been shown to interact with the protein kinase PDK4 and has been shown to play a role in the regulation of PDK4-mediated signaling pathways. This interaction between LIMS2 and PDK4 has been shown to contribute to the regulation of cellular processes such as cell growth, apoptosis, and cell signaling.

Despite its many interesting functions, LIMS2 is still not well understood. Limited research has been conducted on its role in disease, and it is not yet clear what the full implications of its functions are. Further research is needed to fully understand the role of LIMS2 in disease and to develop new treatments based on its potential as a drug target or biomarker.

Protein Name: LIM Zinc Finger Domain Containing 2

Functions: Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Plays a role in modulating cell spreading and migration

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