Target Name: TEPSIN
NCBI ID: G146705
Other Name(s): ENTH domain containing 2 | TEPSIN adaptor related protein complex 4 accessory protein, transcript variant 2 | ENTH domain-containing protein 2 | C17orf56 | ENTHD2 | TEPSIN adaptor related protein complex 4 accessory protein | AP-4 complex accessory subunit Tepsin (isoform 2) | AP-4 complex accessory subunit Tepsin | Epsin for AP-4 | AP-4 accessory protein | TEPSIN variant 2 | tetra-epsin | Tetra-epsin | epsin for AP-4 | AP4AT_HUMAN

TEPSIN: A Key Regulator of ERK and Cellular Signaling

TEPSIN (Transient Endoplasmic Reticulmspanning Protein-Induced Secretion) is a protein that is expressed in most tissues of the body and plays a critical role in the regulation of intracellular signaling pathways. It is a key regulator of the endoplasmic reticulum (ER), which is the membrane-bound portion of the endosomal system that retrieves and modifies proteins before they are released into the cytoplasm.

The ER is a complex organelle that is responsible for the folding and modification of proteins before they are transported to the plasma membrane for secretion or degradation. The ER is composed of a series of membrane-bound transmembrane proteins that span the membrane and are involved in various functions, including protein synthesis, folding, and transport.

One of the proteins that is expressed in the ER is TEPSIN. TEPSIN is a 23-kDa protein that is composed of a single polypeptide chain that is expressed in most tissues of the body. It is primarily localized to the ER and is involved in the regulation of intracellular signaling pathways.

TEPSIN functions as a negative regulator of the ER-associated protein kinase (ERK), which is a critical regulator of various cellular processes, including cell growth, differentiation, and survival. The ERK signaling pathway is involved in the regulation of many different cellular processes , including cell proliferation, apoptosis, angiogenesis, and inflammation.

TEPSIN is able to inhibit the activity of ERK by a mechanism that is similar to that of other protein-inducible secrets (PIS). PISs are small proteins that are able to interact with the ERK and prevent it from activating the signaling pathway that is activated by ERK.

TEPSIN is able to inhibit the activity of ERK by interacting with the active center of protein kinase (PKG) kinase, which is the site where ERK is able to interact with other proteins and activates the signaling pathway. This interaction between TEPSIN and ERK allows TEPSIN to function as a negative regulator of ERK, which means that it prevents ERK from activating the signaling pathway that is activated by its interactions with other proteins.

In addition to its role in regulating ERK, TEPSIN is also involved in the regulation of many other cellular processes. For example, it is involved in the regulation of cell adhesion, which is the process by which cells stick together and form tissues. TEPSIN is also involved in the regulation of the cytoskeleton, which is the structure that gives cells shape and provides support, as well as in the regulation of cell signaling pathways that are involved in cell growth, differentiation, and survival.

In conclusion, TEPSIN is a protein that is expressed in most tissues of the body and plays a critical role in the regulation of intracellular signaling pathways. It is a key regulator of the endoplasmic reticulum and is involved in the regulation of cell adhesion, cytoskeleton, and many other cellular processes. As a result, TEPSIN is a potential drug target and a biomarker for various diseases, including cancer, neurodegenerative diseases, and developmental disorders.

Protein Name: TEPSIN Adaptor Related Protein Complex 4 Accessory Protein

Functions: Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network

More Common Targets

TERB1 | TERB2 | TERC | TERF1 | TERF1P3 | TERF2 | TERF2IP | TERLR1 | TERT | TES | TESC | TESK1 | TESK2 | TESMIN | TESPA1 | TET1 | TET2 | TET2-AS1 | TET3 | Tetraspanin | TEX10 | TEX101 | TEX11 | TEX12 | TEX13A | TEX13B | TEX13C | TEX14 | TEX15 | TEX19 | TEX2 | TEX21P | TEX22 | TEX26 | TEX261 | TEX264 | TEX28 | TEX29 | TEX30 | TEX33 | TEX35 | TEX36 | TEX36-AS1 | TEX37 | TEX38 | TEX41 | TEX43 | TEX44 | TEX45 | TEX46 | TEX47 | TEX48 | TEX49 | TEX50 | TEX52 | TEX53 | TEX55 | TEX56P | TEX9 | TF | TFAM | TFAMP1 | TFAP2A | TFAP2A-AS1 | TFAP2A-AS2 | TFAP2B | TFAP2C | TFAP2D | TFAP2E | TFAP4 | TFB1M | TFB2M | TFCP2 | TFCP2L1 | TFDP1 | TFDP1P2 | TFDP2 | TFDP3 | TFE3 | TFEB | TFEC | TFF1 | TFF2 | TFF3 | TFG | TFIID Basal Transcription Factor Complex | TFIIIC2 complex | TFIP11 | TFIP11-DT | TFPI | TFPI2 | TFPT | TFR2 | TFRC | TG | TGDS | TGFA | TGFA-IT1 | TGFB1 | TGFB1I1