PUS10: A Potential Drug Target for Immune and Inflammatory Diseases

Target Name: PUS10

NCBI ID: G150962

PUS10: A Potential Drug Target for Immune and Inflammatory Diseases

PUS10 (PUS10_HUMAN) is a protein that is expressed in various tissues of the human body, including the placenta, spleen, liver, and kidneys. It is a member of the Pusin family, which includes proteins that are involved in the immune response and inflammation.

PUS10 is a 10-kDa protein that is expressed in the placenta, spleen, liver, and kidneys. It is a member of the Pusin family, which includes proteins that are involved in the immune response and inflammation. PUS10 is made up of 96 amino acid residues and has a calculated pI of 4.75.

One of the unique features of PUS10 is its ability to interact with the immune system. It has been shown to play a role in the regulation of immune cell function and has been shown to interact with a variety of immune molecules, including T cells, B cells, and natural killer cells.

In addition to its role in the immune system, PUS10 has also been shown to play a role in the regulation of inflammation. It has been shown to reduce inflammation in various tissues and has been shown to have anti-inflammatory effects.

PUS10 is also of interest as a potential drug target. Its ability to interact with immune molecules and its anti-inflammatory effects make it a promising target for the development of new treatments for a variety of diseases.

In conclusion, PUS10 is a protein that is expressed in various tissues of the human body and is involved in the immune response and inflammation. Its unique properties make it a promising target for the development of new treatments for a variety of diseases. Further research is needed to fully understand the role of PUS10 in the immune system and its potential as a drug target.

Protein Name: Pseudouridine Synthase 10

Functions: Protein with different functions depending on its subcellular location: involved in miRNA processing in the nucleus and acts as a tRNA pseudouridylate synthase in the cytoplasm (PubMed:31819270, PubMed:33023933). In the cytoplasm, acts as a pseudouridylate synthase by catalyzing synthesis of pseudouridine(54) and pseudouridine(55) from uracil-54 and uracil-55, respectively, in the psi GC loop of a subset of tRNAs (PubMed:30530625, PubMed:31819270, PubMed:33023933). tRNA pseudouridylate synthase activity is enhanced by the presence of 1-methyladenosine at position 53-61 of tRNAs (PubMed:30530625). Does not show tRNA pseudouridylate synthase activity in the nucleus (PubMed:33023933). In the nucleus, promotes primary microRNAs (pri-miRNAs) processing independently of its RNA pseudouridylate synthase activity (PubMed:31819270). Binds pri-miRNAs (PubMed:31819270). Modulator of TRAIL/TNFSF10-induced cell death via activation of procaspase-8 and BID cleavage (PubMed:14527409, PubMed:19712588). Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death (PubMed:19712588)

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