CYP7A1: Key Enzyme for Cholesterol and Sex Hormones (G1581)

Target Name: CYP7A1

NCBI ID: G1581

CYP7A1: Key Enzyme for Cholesterol and Sex Hormones

Cholesterol 7-alpha-hydroxylase (CYP7A1) is an enzyme that plays a crucial role in the production of cholesterol in the body. It is a key enzyme in the liver, and it is involved in the conversion of low-density lipoprotein (LDL) cholesterol to high-density lipoprotein (HDL) cholesterol. This enzyme is also involved in the metabolism of other lipids, including fatty acids and triglycerides.

CYP7A1 is a protein that is expressed in many different tissues in the body, including the liver, heart, and kidneys. It is a potent enzyme that is involved in the production of essential compounds that are important for the body, including hormones, antimicrobial agents , and bile acids. It is also involved in the regulation of cellular signaling pathways, including the production of sex hormones.

One of the main functions of CYP7A1 is the production of HDL cholesterol. HDL cholesterol is an essential component of the immune system, and it helps to protect the body against the risk of heart disease. It is also an important factor in the regulation of cellular signaling pathways, and it is involved in the development and maintenance of tissues, including the brain and eye.

CYP7A1 is also involved in the metabolism of other lipids, including fatty acids and triglycerides. It is a key enzyme in the metabolism of fatty acids, which are essential for the body's energy needs. Ester, which is a type of fat that is stored in the body for energy.

CYP7A1 is a protein that is expressed in many different tissues in the body. It is a potent enzyme that is involved in the production of essential compounds that are important for the body, including hormones, antimicrobial agents, and bile acids. It is also involved in the regulation of cellular signaling pathways, and it is involved in the production of sex hormones.

In addition to its role in the production of HDL cholesterol, CYP7A1 is also involved in the regulation of cellular signaling pathways. It is a key enzyme in the production of sex hormones, including testosterone and estradiol. These hormones are important for the development and maintenance of tissues, including the brain and eye.

CYP7A1 is also involved in the regulation of cellular signaling pathways that are involved in the development and maintenance of tissues, including the brain and eye. It is a key enzyme in the production of sex hormones, including testosterone and estradiol. These hormones are important for the development and maintenance of tissues, including the brain and eye.

In conclusion, CYP7A1 is a protein that is involved in the production of essential compounds that are important for the body, including hormones, antimicrobial agents, and bile acids. It is also involved in the regulation of cellular signaling pathways, and it is a key enzyme in the production of sex hormones. As a drug target or biomarker, CYP7A1 is an attractive target for researchers who are interested in the development of new treatments for a variety of diseases.

Protein Name: Cytochrome P450 Family 7 Subfamily A Member 1

Functions: A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (PubMed:11013305, PubMed:12077124, PubMed:19965590, PubMed:2384150, PubMed:21813643). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:2384150, PubMed:11013305, PubMed:12077124, PubMed:19965590, PubMed:21813643). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis. Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of cholesterol, a rate-limiting step in cholesterol catabolism and bile acid biosynthesis (PubMed:12077124, PubMed:19965590, PubMed:2384150). 7-alpha hydroxylates several oxysterols, including 4beta-hydroxycholesterol and 24-hydroxycholesterol (PubMed:11013305, PubMed:12077124). Catalyzes the oxidation of the 7,8 double bond of 7-dehydrocholesterol and lathosterol with direct and predominant formation of the 7-keto derivatives (PubMed:21813643)

More Common Targets