Lipoxygenase (nonspecified subtype) Related Diseases

Lipoxygenase (nonspecified subtype)

Related Diseases

1) Diabetes Type 2
Type 2 Diabetes Mellitus, also known as insulin resistance, is related to diabetes mellitus and maturity-onset diabetes of the young, type 8, with exocrine dysfunction, and has symptoms including angina pectoris, tremor and equilibration disorder. An important gene associated with Type 2 Diabetes Mellitus is IRS1 (Insulin Receptor Substrate 1), and among its related pathways/superpathways are Nervous system development and Angiopoietin-like protein 8 regulatory pathway. The drugs Glipizide and Glycopyrronium have been mentioned in the context of this disorder. Affiliated tissues include Pancreas and Adipose, and related phenotypes are type ii diabetes mellitus and insulin resistance

2) Stroke
Cerebrovascular Disease, also known as cerebrovascular disorder, is related to basal ganglia cerebrovascular disease and stroke, ischemic, and has symptoms including headache, transient ischemic attacks, stereotypic symptoms and angina pectoris. An important gene associated with Cerebrovascular Disease is HOTAIR (HOX Transcript Antisense RNA), and among its related pathways/superpathways are Signal Transduction and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The drugs Acetylcarnitine and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include brain, bone marrow and heart, and related phenotypes are homeostasis/metabolism and growth/size/body region

3) Stroke, Ischemic
Stroke, Ischemic, also known as cerebral infarction, is related to sneddon syndrome and brain small vessel disease 1, and has symptoms including angina pectoris, back pain and chest pain. An important gene associated with Stroke, Ischemic is F5 (Coagulation Factor V), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Diseases of hemostasis. The drugs Heparin, bovine and Nadroparin have been mentioned in the context of this disorder. Affiliated tissues include Bone and Brain, and related phenotypes are stroke and homeostasis/metabolism

4) Huntington's Disease
Huntington Disease, also known as huntington's disease, is related to huntington disease-like 1 and choreatic disease, and has symptoms including back pain, headache and myoclonus. An important gene associated with Huntington Disease is HTT (Huntingtin), and among its related pathways/superpathways is miRNAs involved in DNA damage response. The drugs Memantine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include Brain, eye and globus pallidus, and related phenotypes are chorea and mental deterioration

5) Migraine
Migraine with or Without Aura 1, also known as migraine, is related to familial hemiplegic migraine and migraine without aura, and has symptoms including back pain, headache and hemiplegia. An important gene associated with Migraine with or Without Aura 1 is NOTCH3 (Notch Receptor 3), and among its related pathways/superpathways are Type II diabetes mellitus and Cellular roles of Anthrax toxin. The drugs Mineral oil and Betamethasone have been mentioned in the context of this disorder. Affiliated tissues include brain, pituitary and cortex, and related phenotypes are photophobia and vomiting

6) Arthritis
Arthritis, also known as inflammatory joint disease, is related to rheumatoid arthritis and juvenile rheumatoid arthritis, and has symptoms including arthralgia, back pain and metatarsalgia. An important gene associated with Arthritis is SYK (Spleen Associated Tyrosine Kinase), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Entecavir and Chlorhexidine have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and bone marrow, and related phenotypes are Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression and homeostasis/metabolism

7) Coronary Heart Disease
Coronary Heart Disease 1, also known as coronary heart disease, is related to angina pectoris and abdominal obesity-metabolic syndrome 1, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Coronary Heart Disease 1 is CX3CR1 (C-X3-C Motif Chemokine Receptor 1), and among its related pathways/superpathways are Metabolism and Transport of inorganic cations/anions and amino acids/oligopeptides. The drugs Simvastatin and Lovastatin have been mentioned in the context of this disorder. Affiliated tissues include Limb and Bone, and related phenotypes are Increased free cholesterol and Increased LDL uptake

8) Atherosclerosis
Atherosclerosis Susceptibility, also known as atherosclerosis, is related to cerebral atherosclerosis and generalized atherosclerosis, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Atherosclerosis Susceptibility is ATHS (Atherosclerosis Susceptibility (Lipoprotein Associated)), and among its related pathways/superpathways are "Plasma lipoprotein assembly, remodeling, and clearance" and Interleukin-4 and Interleukin-13 signaling. The drugs Enalaprilat and Enalapril have been mentioned in the context of this disorder. Affiliated tissues include Heart, and related phenotypes are hypertriglyceridemia and myocardial infarction

9) Asthma
Asthma, also known as chronic obstructive asthma, is related to allergic asthma and childhood-onset asthma, and has symptoms including recurring periods of wheezing, chest tightness and shortness of breath. An important gene associated with Asthma is IL13 (Interleukin 13), and among its related pathways/superpathways are Allograft rejection and Interleukin-4 and Interleukin-13 signaling. The drugs Fentanyl and Etomidate have been mentioned in the context of this disorder. Affiliated tissues include Lung, smooth muscle and skin, and related phenotypes are asthma and bronchoconstriction

10) Multiple Sclerosis
Multiple Sclerosis, also known as ms, is related to pediatric multiple sclerosis and autoimmune hepatitis, and has symptoms including back pain, headache and hemiplegia. An important gene associated with Multiple Sclerosis is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Phosphorylation of CD3 and TCR zeta chains and Cell differentiation - expanded index. The drugs Acetaminophen and Promethazine have been mentioned in the context of this disorder. Affiliated tissues include Neural Tube and Limb, and related phenotypes are spasticity and diplopia

11) Multiple Myeloma
Myeloma, Multiple, also known as multiple myeloma, is related to monoclonal gammopathy of uncertain significance and plasma cell neoplasm. An important gene associated with Myeloma, Multiple is LIG4 (DNA Ligase 4), and among its related pathways/superpathways are Breast cancer pathway and MAPK Signaling: Mitogens. The drugs Busulfan and Levofloxacin have been mentioned in the context of this disorder. Affiliated tissues include Blood, and related phenotypes are osteopenia and pathologic fracture

12) Dementia
Dementia, also known as mental and behavioural disorders due to use of sedatives or hypnotics, residual and late-onset psychotic disorder, is related to dementia, lewy body and frontotemporal dementia, and has symptoms including angina pectoris, back pain and headache. An important gene associated with Dementia is PSEN1 (Presenilin 1), and among its related pathways/superpathways are Alzheimer's disease and miRNA effects and Neuroscience. The drugs Mirabegron and Ketamine have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and bone marrow, and related phenotypes are no effect and no effect

13) Parkinson's Disease
Parkinson Disease, Late-Onset, also known as parkinson disease, is related to hereditary late-onset parkinson disease and parkinson disease 3, autosomal dominant, and has symptoms including angina pectoris, back pain and headache. An important gene associated with Parkinson Disease, Late-Onset is MAPT (Microtubule Associated Protein Tau), and among its related pathways/superpathways is Parkinson's disease pathway. The drugs Idebenone and Tadalafil have been mentioned in the context of this disorder. Affiliated tissues include Brain, and related phenotypes are hallucinations and abnormal autonomic nervous system physiology

14) Angina Pectoris
Angina Pectoris, also known as prinzmetal's variant angina, is related to polycythemia vera and intermittent claudication, and has symptoms including other and unspecified angina pectoris An important gene associated with Angina Pectoris is EDN1 (Endothelin 1), and among its related pathways/superpathways are Signal Transduction and Response to elevated platelet cytosolic Ca2+. The drugs Candesartan cilexetil and Amiodarone have been mentioned in the context of this disorder. Affiliated tissues include heart, smooth muscle and bone marrow, and related phenotypes are homeostasis/metabolism and muscle

15) Heart Failure
Congestive Heart Failure, also known as congestive heart disease, is related to cardiomyopathy, dilated, 1e and orthostatic intolerance, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Congestive Heart Failure is CDKN2B-AS1 (CDKN2B Antisense RNA 1), and among its related pathways/superpathways are Cardiac conduction and "Antiarrhythmic Pathway, Pharmacodynamics". The drugs Salbutamol and Thalidomide have been mentioned in the context of this disorder. Affiliated tissues include Adipose and Lateral Plate Mesoderm, and related phenotypes are muscle and homeostasis/metabolism

16) Acute Myeloid Leukemia
Acute Myeloblastic Leukemia with Maturation, also known as acute myeloblastic leukemia type 2, is related to myeloid leukemia and myeloid sarcoma. An important gene associated with Acute Myeloblastic Leukemia with Maturation is MIR181A1HG (MIR181A1 Host Gene), and among its related pathways/superpathways are Ras signaling and Hematopoietic Stem Cells and Lineage-specific Markers. The drugs Nicotine and Amsacrine have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone marrow and t cells, and related phenotypes are Decreased substrate adherent cell growth and Decreased substrate adherent cell growth

17) Acute Kidney Injury
Acute Kidney Failure, also known as acute renal failure, is related to hemolytic-uremic syndrome and hemolytic uremic syndrome, atypical 1. An important gene associated with Acute Kidney Failure is MGAT3-AS1 (MGAT3 Antisense RNA 1), and among its related pathways/superpathways are Interleukin-4 and Interleukin-13 signaling and "Uricosurics Pathway, Pharmacodynamics". The drugs Desflurane and Racephedrine have been mentioned in the context of this disorder. Affiliated tissues include Bone and Adipose, and related phenotypes are homeostasis/metabolism and cardiovascular system

18) Depression
Major Depressive Disorder, also known as seasonal affective disorder, is related to anxiety and endogenous depression, and has symptoms including affective symptoms, behavioral symptoms and schizophrenic language. An important gene associated with Major Depressive Disorder is HTR2A (5-Hydroxytryptamine Receptor 2A), and among its related pathways/superpathways are Signal Transduction and Neuroscience. The drugs Fluvoxamine and Valsartan have been mentioned in the context of this disorder. Affiliated tissues include brain, prefrontal cortex and cortex, and related phenotypes are depression and behavior/neurological

19) Lymphoma
Lymphosarcoma, also known as lymphoma, diffuse, is related to lymphoma, non-hodgkin, familial and lymphoma, hodgkin, classic. An important gene associated with Lymphosarcoma is BCL6 (BCL6 Transcription Repressor), and among its related pathways/superpathways are Direct p53 effectors and Interleukin-4 and Interleukin-13 signaling. The drugs Crofelemer and Aprepitant have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone marrow and myeloid.

20) Ulcerative Colitis
Inflammatory Bowel Disease 1, also known as inflammatory bowel disease 1, is related to inflammatory bowel disease 19 and inflammatory bowel disease 17, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Inflammatory Bowel Disease 1 is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Innate Immune System and NF-kappaB Signaling. The drugs Magnesium citrate and Prucalopride have been mentioned in the context of this disorder. Affiliated tissues include colon, bone marrow and bone, and related phenotypes are growth delay and abdominal pain

21) Inflammatory Bowel Disease
Inflammatory Bowel Disease, also known as inflammatory bowel diseases, is related to inflammatory bowel disease 6 and inflammatory bowel disease 9. An important gene associated with Inflammatory Bowel Disease is IL37 (Interleukin 37). The drugs Copper and Zinc cation have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and bone marrow.

22) Anxiety Disorders
Anxiety, also known as anxiety disorders, is related to generalized anxiety disorder and separation anxiety disorder, and has symptoms including nervousness, agitation and feeling tense. An important gene associated with Anxiety is SLC6A4 (Solute Carrier Family 6 Member 4), and among its related pathways/superpathways are Signal Transduction and Class A/1 (Rhodopsin-like receptors). The drugs Amlodipine and Lorazepam have been mentioned in the context of this disorder. Affiliated tissues include brain, breast and thyroid, and related phenotypes are nervous system and normal

23) Periodontitis
Periodontitis, also known as chronic pericementitis, is related to periodontitis, chronic and periodontitis, aggressive, 1, and has symptoms including leukorrhea and purulent discharge. An important gene associated with Periodontitis is CDKN2B-AS1 (CDKN2B Antisense RNA 1), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Sodium fluoride and Menthol have been mentioned in the context of this disorder. Affiliated tissues include bone, neutrophil and endothelial, and related phenotypes are homeostasis/metabolism and immune system

24) Idiopathic Pulmonary Fibrosis
Acute Interstitial Pneumonia, also known as acute interstitial pneumonitis, is related to mikulicz disease and pulmonary fibrosis, and has symptoms including dyspnea on exertion and dry cough. An important gene associated with Acute Interstitial Pneumonia is SFTPD (Surfactant Protein D), and among its related pathways/superpathways are Disease and Innate Immune System. The drugs Nintedanib and Protein Kinase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include lung, bone marrow and bone, and related phenotypes are dyspnea and respiratory failure

25) Atopic Dermatitis
Dermatitis, Atopic, also known as atopic dermatitis, is related to allergic disease and dermatitis, atopic, 3, and has symptoms including exanthema and pruritus. An important gene associated with Dermatitis, Atopic is FLG (Filaggrin), and among its related pathways/superpathways are MIF Mediated Glucocorticoid Regulation and Cytokine Signaling in Immune system. The drugs Zinc oxide and Coal tar have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and breast, and related phenotypes are cataract and ichthyosis

26) Pain
Paine Syndrome, also known as pain disorder, is related to paroxysmal extreme pain disorder and indifference to pain, congenital, autosomal recessive. An important gene associated with Paine Syndrome is HFE (Homeostatic Iron Regulator), and among its related pathways/superpathways are Cardiac conduction and Neuropathic Pain-Signaling in Dorsal Horn Neurons. The drugs Pregabalin and Dinoprostone have been mentioned in the context of this disorder. Affiliated tissues include dorsal root ganglion, spinal cord and breast, and related phenotypes are microcephaly and spastic diplegia

27) Cancer, Breast
Breast Cancer, also known as breast carcinoma, is related to ovarian cancer and hereditary breast ovarian cancer syndrome, and has symptoms including pelvic pain, lameness, animal and pain. An important gene associated with Breast Cancer is BRCA2 (BRCA2 DNA Repair Associated), and among its related pathways/superpathways are Gene expression (Transcription) and ERK Signaling. The drugs Prednisolone phosphate and Prednisolone acetate have been mentioned in the context of this disorder. Affiliated tissues include breast, lymph node and prostate, and related phenotypes are breast carcinoma and Decreased viability

28) Cancer, Prostate
Prostate Cancer, also known as prostate carcinoma, is related to breast cancer and prostate disease, and has symptoms including angina pectoris, tremor and equilibration disorder. An important gene associated with Prostate Cancer is CHEK2 (Checkpoint Kinase 2), and among its related pathways/superpathways are Endometrial cancer and Breast cancer pathway. The drugs Sodium citrate and Sildenafil have been mentioned in the context of this disorder. Affiliated tissues include prostate, bone and lymph node, and related phenotypes are prostate cancer and neoplasm

29) Cancer, Brain
Brain Cancer, also known as malignant neoplasm of brain, is related to li-fraumeni syndrome and lung cancer, and has symptoms including back pain, headache and pain. An important gene associated with Brain Cancer is MIR142 (MicroRNA 142), and among its related pathways/superpathways are ERK Signaling and Signal Transduction. The drugs Fentanyl and Dexmedetomidine have been mentioned in the context of this disorder. Affiliated tissues include brain, breast and lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

30) Cancer, Colon
Colorectal Cancer, also known as colon cancer, is related to lynch syndrome and colonic benign neoplasm, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Colorectal Cancer is CTNNB1 (Catenin Beta 1), and among its related pathways/superpathways are Disease and ERK Signaling. The drugs Tramadol and Ferrous fumarate have been mentioned in the context of this disorder. Affiliated tissues include colon, rectum and liver, and related phenotypes are renal cell carcinoma and neoplasm of the stomach

31) Epilepsy
Epilepsy, also known as epilepsy syndrome, is related to epilepsy, myoclonic juvenile and childhood absence epilepsy, and has symptoms including back pain, headache and pain. An important gene associated with Epilepsy is SCN1A (Sodium Voltage-Gated Channel Alpha Subunit 1), and among its related pathways/superpathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Neuroscience. The drugs Ethosuximide and Vigabatrin have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and thalamus, and related phenotypes are nervous system and growth/size/body region

32) Dermatomyositis
Dermatomyositis, also known as amyopathic dermatomyositis, is related to inclusion body myositis and interstitial lung disease, and has symptoms including exanthema and pruritus. An important gene associated with Dermatomyositis is RN7SL1 (RNA Component Of Signal Recognition Particle 7SL1), and among its related pathways/superpathways are miRNAs involvement in the immune response in sepsis and miRNAs involved in DNA damage response. The drugs Pirfenidone and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include muscle, skin where a skin rash is often seen prior to the onset of muscle weakness and skin, and related phenotypes are autoimmunity and emg abnormality

33) Scleroderma, Diffuse
Diffuse Scleroderma, also known as diffuse systemic sclerosis, is related to scleroderma, familial progressive and crest syndrome, and has symptoms including exanthema, pruritus and hidebound skin. An important gene associated with Diffuse Scleroderma is TOP1 (DNA Topoisomerase I), and among its related pathways/superpathways is Angiotensin II receptor type 1 pathway. The drugs Ambrisentan and Bosentan have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and endothelial.

34) Rheumatoid Arthritis
Rheumatoid Arthritis, also known as ra, is related to arthritis and psoriatic arthritis, and has symptoms including back pain, muscle cramp and sciatica. An important gene associated with Rheumatoid Arthritis is PTPN22 (Protein Tyrosine Phosphatase Non-Receptor Type 22), and among its related pathways/superpathways are NF-kappaB Signaling and Genes associated with the development of rheumatoid arthritis. The drugs Entecavir and Alendronic acid have been mentioned in the context of this disorder. Affiliated tissues include Cartilage, joint and bone, and related phenotypes are joint stiffness and fatigue

35) Acne
Acne, also known as acne vulgaris, is related to sapho syndrome and hidradenitis suppurativa, and has symptoms including exanthema and pruritus. An important gene associated with Acne is NCSTN (Nicastrin), and among its related pathways/superpathways are Innate Immune System and Prolactin Signaling. The drugs Calcipotriol and Adapalene have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and thyroid, and related phenotypes are no effect and no effect

36) Schizophrenia
Schizophrenia, also known as schizophrenia with or without an affective disorder, is related to schizoaffective disorder and psychotic disorder, and has symptoms including sleep disturbances, photophobia and personality changes. An important gene associated with Schizophrenia is RTN4R (Reticulon 4 Receptor), and among its related pathways/superpathways are "Methylphenidate Pathway, Pharmacodynamics" and MTHFR deficiency. The drugs Molindone and Asenapine have been mentioned in the context of this disorder. Affiliated tissues include brain, prefrontal cortex and cortex, and related phenotypes are eeg abnormality and hallucinations

37) Diabetes
Diabetes Mellitus, also known as diabetes, is related to type 2 diabetes mellitus and gestational diabetes, and has symptoms including angina pectoris, tremor and equilibration disorder. An important gene associated with Diabetes Mellitus is KCNJ11 (Potassium Inwardly Rectifying Channel Subfamily J Member 11), and among its related pathways/superpathways are Regulation of beta-cell development and Cell differentiation - expanded index. The drugs Miconazole and Clotrimazole have been mentioned in the context of this disorder. Affiliated tissues include pancreas, bone marrow and kidney.

38) Systemic Lupus Erythematosus
Systemic Lupus Erythematosus, also known as lupus nephritis, is related to lupus erythematosus and autoimmune disease, and has symptoms including exanthema, pruritus and lupus-like rash. An important gene associated with Systemic Lupus Erythematosus is TREX1 (Three Prime Repair Exonuclease 1), and among its related pathways/superpathways are Innate Immune System and NF-kappaB Signaling. The drugs Sulfamethoxazole and Trimethoprim have been mentioned in the context of this disorder. Affiliated tissues include Umbilical Cord, bone marrow and skin, and related phenotypes are lupus nephritis and arthritis

39) Colitis
Colitis is related to ulcerative colitis and inflammatory bowel disease 1. An important gene associated with Colitis is SYK (Spleen Associated Tyrosine Kinase), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Magnesium citrate and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include colon, bone marrow and t cells, and related phenotypes are no effect and no effect

40) Ischemia
Ischemia, also known as acute coronary syndrome, is related to limb ischemia and lipoprotein quantitative trait locus, and has symptoms including anoxemia, polydipsia and muscle weakness. An important gene associated with Ischemia is LINC01254 (Long Intergenic Non-Protein Coding RNA 1254), and among its related pathways/superpathways are Signal Transduction and Response to elevated platelet cytosolic Ca2+. The drugs Lovastatin and Nadroparin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, heart and brain, and related phenotypes are homeostasis/metabolism and nervous system

41) Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex 1, also known as guam disease, is related to frontotemporal dementia and/or amyotrophic lateral sclerosis 3 and frontotemporal dementia and/or amyotrophic lateral sclerosis 2, and has symptoms including tremor, bradykinesia and abnormality of extrapyramidal motor function. An important gene associated with Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex 1 is TRPM7 (Transient Receptor Potential Cation Channel Subfamily M Member 7), and among its related pathways/superpathways are Neuroscience and Copper homeostasis. The drugs Varenicline and Riluzole have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, spinal cord and brain, and related phenotypes are muscle weakness and dementia

42) Cirrhosis
Liver Cirrhosis, also known as cirrhosis, is related to alcoholic liver cirrhosis and primary biliary cholangitis, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Liver Cirrhosis is FARSB (Phenylalanyl-TRNA Synthetase Subunit Beta), and among its related pathways/superpathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Lung fibrosis. The drugs Racivir and Propofol have been mentioned in the context of this disorder. Affiliated tissues include Bone and Blood.

43) Liver Diseases
Liver Disease, also known as liver diseases, is related to non-alcoholic fatty liver disease and fatty liver disease, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Liver Disease is MEG3 (Maternally Expressed 3), and among its related pathways/superpathways are Metabolism and Nuclear receptors meta-pathway. The drugs Perindopril and Amlodipine have been mentioned in the context of this disorder. Affiliated tissues include liver, bone marrow and kidney, and related phenotypes are Reduced mammosphere formation and liver/biliary system

44) Hepatic Steatosis
Fatty Liver Disease, Nonalcoholic 1, also known as nafld1, is related to non-alcoholic fatty liver disease and fatty liver disease. An important gene associated with Fatty Liver Disease, Nonalcoholic 1 is ATG7 (Autophagy Related 7). The drugs Metformin and Entecavir have been mentioned in the context of this disorder. Affiliated tissues include liver, skeletal muscle and kidney, and related phenotype is hepatic steatosis.

45) Irritable Bowel Syndrome
Irritable Bowel Syndrome, also known as irritable colon, is related to fibromyalgia and lactose intolerance, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Irritable Bowel Syndrome is SLC6A4 (Solute Carrier Family 6 Member 4), and among its related pathways/superpathways are Signal Transduction and GPCR downstream signalling. The drugs Clarithromycin and Simethicone have been mentioned in the context of this disorder. Affiliated tissues include colon, brain and kidney, and related phenotypes are homeostasis/metabolism and nervous system

46) Obesity
Body Mass Index Quantitative Trait Locus 11, also known as obesity, is related to leptin deficiency or dysfunction and type 2 diabetes mellitus, and has symptoms including high weight, symptoms and obesity, metabolically benign. An important gene associated with Body Mass Index Quantitative Trait Locus 11 is UCP3 (Uncoupling Protein 3), and among its related pathways/superpathways are Beta-2 adrenergic-dependent CFTR expression and Glucose / Energy Metabolism. The drugs Hydrocortisone and Hydrocortisone succinate have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, liver and heart, and related phenotypes are obesity and decreased resting energy expenditure

47) Nephropathy
Kidney Disease, also known as renal failure, is related to chronic kidney disease and polycystic kidney disease, and has symptoms including polyuria An important gene associated with Kidney Disease is TSC1 (TSC Complex Subunit 1), and among its related pathways/superpathways are Ciliopathies and Bardet-Biedl syndrome. The drugs Amiodarone and Nicotinamide have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and bone marrow, and related phenotypes are homeostasis/metabolism and renal/urinary system

48) Glioblastoma
Glioblastoma, also known as glioblastoma multiforme, is related to brain cancer and glioma, and has symptoms including headache and seizures. An important gene associated with Glioblastoma is MIR21 (MicroRNA 21), and among its related pathways/superpathways is miRNAs involved in DNA damage response. The drugs Trametinib and Dabrafenib have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and eye, and related phenotypes are glioblastoma multiforme and abnormal cell morphology

49) Diarrhea
Diarrhea, also known as diarrhoea, is related to diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies and microvillus inclusion disease. An important gene associated with Diarrhea is WNT2B (Wnt Family Member 2B), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers and Digestion and absorption. The drugs Ceftriaxone and Zinc cation have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and kidney, and related phenotypes are no effect and no effect

50) Cystitis, Interstitial
Interstitial Cystitis, also known as painful bladder syndrome, is related to chronic pain and low compliance bladder, and has symptoms including unspecified symptom associated with female genital organs, mittelschmerz and pain and other symptoms associated with female genital organs. An important gene associated with Interstitial Cystitis is P3H4 (Prolyl 3-Hydroxylase Family Member 4 (Inactive)), and among its related pathways/superpathways are Signal Transduction and Overview of interferons-mediated signaling pathway. The drugs Hesperidin and Polidocanol have been mentioned in the context of this disorder. Affiliated tissues include kidney, brain and smooth muscle, and related phenotypes are abnormality of the menstrual cycle and abnormality of the urethra

51) Overactive Bladder
Low Compliance Bladder, also known as overactive bladder, is related to interstitial cystitis and paine syndrome, and has symptoms including dysuria, urgency of micturition and prostatism. An important gene associated with Low Compliance Bladder is P2RX3 (Purinergic Receptor P2X 3), and among its related pathways/superpathways are Signal Transduction and Myometrial relaxation and contraction pathways. The drugs Propiverine and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, smooth muscle and prostate.

52) Autoimmune Disease
Autoimmune Disease, also known as autoimmune diseases, is related to vitiligo-associated multiple autoimmune disease susceptibility 1 and systemic lupus erythematosus. An important gene associated with Autoimmune Disease is AIS4 (Autoimmune Disease, Susceptibility To, 4), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Sofosbuvir and Ledipasvir have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone marrow and skin, and related phenotypes are autoimmune antibody positivity and endocrine/exocrine gland

53) AIDS
Acquired Immunodeficiency Syndrome, also known as acquired immune deficiency syndrome, is related to human immunodeficiency virus type 1 and aids dementia complex. An important gene associated with Acquired Immunodeficiency Syndrome is HCP5 (HLA Complex P5), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Ethambutol and Pyrazinamide have been mentioned in the context of this disorder. Affiliated tissues include t cells, breast and bone marrow, and related phenotypes are neoplasm and endocrine/exocrine gland

54) Leber Hereditary Optic Neuropathy
Leber Hereditary Optic Neuropathy, Modifier of, also known as leber hereditary optic neuropathy, is related to mitochondrial complex i deficiency, nuclear type 1 and leber optic atrophy and dystonia, and has symptoms including ataxia and static tremor. An important gene associated with Leber Hereditary Optic Neuropathy, Modifier of is MT-ND6 (Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 6), and among its related pathways/superpathways are Metabolism and "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.". The drugs Curcumin and Bezafibrate have been mentioned in the context of this disorder. Affiliated tissues include eye, bone marrow and brain, and related phenotypes are mitochondrial respiratory chain defects and slow decrease in visual acuity

55) Thrombosis
Complement Hyperactivation, Angiopathic Thrombosis, and Protein-Losing Enteropathy, also known as chaple, is related to blood group, cromer system and protein-losing enteropathy. An important gene associated with Complement Hyperactivation, Angiopathic Thrombosis, and Protein-Losing Enteropathy is CD55 (CD55 Molecule (Cromer Blood Group)). The drugs Dabigatran and Norethisterone have been mentioned in the context of this disorder. Affiliated tissues include liver, whole blood and endothelial, and related phenotypes are thrombocytosis and hepatomegaly

56) Retinopathy, Diabetic
Microvascular Complications of Diabetes 5, also known as diabetic retinopathy, is related to microvascular complications of diabetes 1 and type 1 diabetes mellitus. An important gene associated with Microvascular Complications of Diabetes 5 is PON1 (Paraoxonase 1), and among its related pathways/superpathways are ERK Signaling and Signal Transduction. The drugs Mecobalamin and Hydroxocobalamin have been mentioned in the context of this disorder. Affiliated tissues include Eye, and related phenotypes are homeostasis/metabolism and cardiovascular system

57) Keratosis, Actinic
Actinic Keratosis, also known as solar keratosis, is related to keratosis and squamous cell carcinoma. An important gene associated with Actinic Keratosis is TP63 (Tumor Protein P63), and among its related pathways/superpathways are Toll-like receptor signaling pathway and Toll-Like receptor Signaling Pathways. The drugs Prilocaine and Bacitracin have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and liver, and related phenotypes are endocrine/exocrine gland and neoplasm

58) Hyperkeratosis
Palmoplantar Keratoderma, Epidermolytic, also known as epidermolytic palmoplantar keratoderma, is related to palmoplantar keratoderma, nonepidermolytic, focal or diffuse and palmoplantar keratoderma, nonepidermolytic. An important gene associated with Palmoplantar Keratoderma, Epidermolytic is KRT9 (Keratin 9), and among its related pathways/superpathways are Nervous system development and Keratinization. The drugs Antibodies and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and heart, and related phenotypes are epidermal hyperkeratosis and abnormal fingernail morphology

59) Psoriasis
Psoriasis is related to psoriasis 7 and psoriasis 10, and has symptoms including exanthema, pruritus and psoriasiform rash. An important gene associated with Psoriasis is MIR203A (MicroRNA 203a), and among its related pathways/superpathways are miRNAs involvement in the immune response in sepsis and Cell differentiation - expanded index. The drugs Metformin and Vedolizumab have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and endothelial.

60) Osteoporosis
Bone Mineral Density Quantitative Trait Locus 8, also known as osteoporosis, is related to osteoporosis and bone mineral density quantitative trait locus 15, and has symptoms including angina pectoris, back pain and muscle cramp. An important gene associated with Bone Mineral Density Quantitative Trait Locus 8 is BMND8 (Bone Mineral Density Quantiative Trait Locus 8). The drugs Clobetasol and Hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and spinal cord.

61) Myelodysplasia
Myelodysplastic Syndrome, also known as myelodysplastic syndromes, is related to leukemia, acute myeloid and juvenile myelomonocytic leukemia. An important gene associated with Myelodysplastic Syndrome is TET2 (Tet Methylcytosine Dioxygenase 2), and among its related pathways/superpathways is Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers. The drugs Posaconazole and Micafungin have been mentioned in the context of this disorder. Affiliated tissues include Placenta and Umbilical Cord, and related phenotypes are myelodysplasia and neoplasm

62) Hypercholesterolemia
Hypercholesterolemia, Familial, 3, also known as hypercholesterolemia, autosomal dominant, 3, is related to hyperaldosteronism, familial, type iii and strabismus. An important gene associated with Hypercholesterolemia, Familial, 3 is PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9). The drugs Probucol and Cilostazol have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and skin, and related phenotypes are hypercholesterolemia and xanthelasma

63) Hyperlipidemia
Familial Hyperlipidemia, also known as familial hyperlipoproteinemia, is related to hyperlipoproteinemia, type v and hyperlipoproteinemia, type i. An important gene associated with Familial Hyperlipidemia is APOB (Apolipoprotein B), and among its related pathways/superpathways are Metabolism and Transport of inorganic cations/anions and amino acids/oligopeptides. The drugs Evolocumab and Dapagliflozin have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and endothelial, and related phenotypes are no effect and no effect

64) Hypertension
Hypertension, Essential, also known as essential hypertension, is related to pulmonary hypertension and renovascular hypertension, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Hypertension, Essential is PTGIS (Prostaglandin I2 Synthase), and among its related pathways/superpathways are Development Angiotensin activation of ERK and "Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics". The drugs Digoxin and Warfarin have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and eye, and related phenotypes are elevated systolic blood pressure and elevated diastolic blood pressure

65) Dental Caries
Dental Caries, also known as dental caries extending into pulp, is related to aplasia of lacrimal and salivary glands and enamel caries, and has symptoms including halitosis and snoring. An important gene associated with Dental Caries is ATP2B3 (ATPase Plasma Membrane Ca2+ Transporting 3). The drugs Salicylic acid and Sorbitol have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, bone and bone marrow, and related phenotypes are no effect and no effect

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