Thrombosis
About the Disease
Complement Hyperactivation, Angiopathic Thrombosis, and Protein-Losing Enteropathy, also known as chaple, is related to blood group, cromer system and protein-losing enteropathy. An important gene associated with Complement Hyperactivation, Angiopathic Thrombosis, and Protein-Losing Enteropathy is CD55 (CD55 Molecule (Cromer Blood Group)). The drugs Dabigatran and Norethisterone have been mentioned in the context of this disorder. Affiliated tissues include liver, whole blood and endothelial, and related phenotypes are thrombocytosis and hepatomegaly
Common Targets / Biomarkers
Integrin alphavbeta3 (vitronectin) receptor | NFE2L2 | CHST15 | EPCAM | F2RL1 | PROC | Heat shock protein 90 (nonspecified subtype) | Integrin alpha4beta1 (VLA-4) receptor | ITPR2 | THBS1 | KLK7 | Serine/threonine-protein kinase (PAK) (nonspecified subtype) | PPARA | Prostanoid Receptor (nonspecified subtype) | Diacylglycerol Acyltransferase (DGAT) (nonspecified subtype) | Prostaglandin EP Receptor (nonspecified subtype) | VWF | PF4 | PREP | Tyrosine-Protein Kinases Src (nonspecified subtype) | F9 | PADI4 | KCNA3 | P2RY1 | cAMP Phosphodiesterase (nonspecified subtype) | DUSP3 | XYLB | Protein kinase C (nonspecified subtype) | RAC1 | GPR119 | SLC9A1 | Protein Kinase B (PKB/Akt) (nonspecified subtype) | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | ASNS | L-type voltage-dependent calcium channel complex | ADRA1A | P2RX1 | NGFR | CYSLTR1 | Calcium channel (nonspecified subtype) | AXL | ITPR3 | LGALS3 | FKBP1A | TRPM8 | KMT2C | ACE2 | ST14 | MTOR | PTPRS | F13A1 | EPHX2 | FFAR1 | ORAI1 | MAOA | KNG1 | MIR23A | EGF | HTR1A | PLA2G4A | PPARG | PTGER3 | Phosphodiesterase 1 (PDE1) (nonspecified subtype) | CNR1 | Cyclophilins (nonspecified subtype) | Alpha-2 Adrenergic receptors (nonspecified subtype) | ADRA2B | SLC6A2 | SPHK2 | CDK5/p25 | TYR | Lipoxygenase (nonspecified subtype) | P2Y purinoceptor (nonspecified subtype) | CHEK1 | Mitogen-Activated Protein Kinase (MAP Kinase)-Activated Protein Kinase (nonspecified subtype) | F11R | CASP9 | SELL | TRPV1 | P2RY2 | PTGIR | PIK3CD | HRH2 | PARP1 | MAP3K5 | RHCE | ALOX12 | HMGCR | BMX | Phospholipase A2 (nonspecified subtype) | PIK3CB | CDK5 | PAR Receptor (nonspecified subtype) | Calcium release-activated channel (CRAC) | APLNR | VKORC1 | HDAC1 | ICAM1 | PTGS1 | SIRT1 | GP1BA | Chymotrypsin (nonspecified subtype) | BCR | ADORA1 | NOD2 | GABA(A) receptor | P2RX3 | ITGA2B | PROCR | HSD11B1 | CALM1 | TNFSF11 | Integrin Receptor (nonspecified subtype) | DYRK1A | F3 | ADAM17 | ACHE | CSNK2A1 | P2RY4 | cGMP Phosphdiesterase (PDE) (nonspecified subtype) | GNAQ | G protein-Coupled Inwardly-Rectifying Potassium Channel (GIRK) (nonspecified subtype) | CCN2 | DPP4 | ABCA1 | CCR2 | S1PR4 | PPARD | PTGS2 | ADORA2A | Acetylcholine Receptors (Nicotinic) (nAChR) (nonspecified subtype) | Tubulin | CACNA1C | Phospholipase C (nonspecified subtype) | PIK3CA | AVPR2 | APOH | SYK | F10 | NTRK1 | FLT1 | PCSK9 | Reverse transcriptase (Telomerase) | INS | Alcohol Dehydrogenase (nonspecified subtype) | TGFBR1 | Tyrosine Kinase (nonspecified subtype) | Gap junction Connexin ( (nonspecified subtype) | ZFP36L2 | YWHAZ | AKR1B1 | ABCB1 | PTPN1 | XDH | Guanylate cyclase (nonspecified subtype) | ADRA2A | F2 | P2RY6 | TGM2 | VCAM1 | BCHE | MTHFR | LIPA | MMP9 | SERPINC1 | FGA | MASP2 | SELP | ITGB2 | GSK3B | Integrin alpha5beta1 (VLA-5) receptor | PIK3C2A | Adenylate Cyclase (nonspecified subtype) | TET2 | Myosin Class II (nonspecified subtype) | P2RY11 | TMPRSS11D | CES1 | NR1H4 | Integrin alphavbeta5 receptor | SERPINE1 | PDPN | CLEC1B | SLC44A2 | CASP3 | GJA8 | BAX | TMPRSS2 | NOS3 | Mitogen-Activated Protein Kinase (nonspecified subtype) | EGFR | Integrin alphaIIbbeta3 (fibrinogen gpIIb/IIIa) receptor | OPRD1 | PIK3C2B | PTGER4 | IL10 | KCNJ3 | CPB1 | KDR | KCNA5 | GUSB | K(ATP) Channel (nonspecified subtype) | PLG | P2RX4 | MERTK | 15-Lipoxygenase (nonspecified subtype) | TEK | PLAT | PTGDR | IL-6 receptor | Vascular endothelial growth factor receptor (VEGFR) (nonspecified subtype) | SLC6A4 | CYP3A5 | MYH2 | MPIG6B | UHRF1 | IgE Receptors (nonspecified subtype) | SUMO1 | ADRB1 | FASN | GNRHR | PTGDR2 | Phospholipase A2, Cytosolic (nonspecified subtype) | CDK1/Cyclin B | Trypsin (nonspecified subtype) | TCF7 | PDE5A | ADIPOR1 | AKR1C3 | beta-Adrenoceptor (nonspecified subtype) | P2RY12 | MBL2 | Elastase (nonspecified subtype) | IL1B | ABCC8 | Cysteine Protease (nonspecified subtype) | VEGFA | NEDD9 | TNFRSF11A | CPB2 | Prostanoid TP receptor (nonspecified subtype) | Serine protease (nonspecified subtype) | HTR2A | Carboxypeptidase N | F5 | ACKR3 | AP-1 Transcription Factor Complex | SELPLG | IL6 | Immunoglobulin E (IgE) | KCNJ5 | GUCY1A1 | TRPA1 | Class III phosphatidylinositol 3-kinase (PI3-kinase) sub-complex | NOS2 | NMDA receptor | TSPAN15 | PDE3B | Kallikrein (nonspecified subtype) | FASLG | ADRA1D | PDE2A | Dopamine receptor (nonspecified subtype) | CDK2/Cyclin A | HRH1 | PIK3C3 | P2X Receptor (nonspecified subtype) | MPL | FCN1 | CYP2C9 | HSD11B2 | Sterol O-acyltransferase (ACAT) (nonspecified subtype) | L-Type calcium channel (nonspecified subtype) | Janus Kinase (nonspecified subtype) | AGTR1 | TXNRD1 | TYRO3 | GAA | Carboxypeptidase B (nonspecified subtype) | Leukotriene B4 receptor (LTB4-R) (nonspecified subtype) | NOX3 | HTR1B | Tryptase (nonspecified subtype) | Vasopressin Receptor (nonspecified subtype) | S1PR5 | Integrin alpha2beta3 Receptor | FGF1 | PON1 | Integrin alphavbeta6 receptor | 5-Hydroxytryptamine Receptor 2 (5-HT2) (nonspecified subtype) | Histone deacetylase (nonspecified subtype) | FCGR2A | JAK2 | ADRB2 | Muscarinic Acetylcholine Receptor (mAChR) (nonspecified subtype) | Gastric H+/K+-ATPase | Proteasome Complex | ZNF568 | TERT | SERPINF2 | ITGB3 | Cyclooxygenase (COX) (nonspecified subtype) | alpha1-Adrenoceptor (nonspecified subtype) | Cannabinoid receptor (nonspecified subtype) | UGT1A1 | NLRP3 Inflammasome | ADIPOR2 | Adenosine receptor (nonspecified subtype) | Inosine 5'-monophosphate dehydrogenase (IMPDH) (nonspecified subtype) | NAT8B | NOX1 | APOE | Coagulation Factor XIII | PARP2 | PROS1 | HPSE | TIGIT | PLAU | AKR1B10 | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7 (nonspecified protein) | CD47 | Inositol 1,4,5-Trisphosphate Receptor (InsP3R) (nonspecified subtype) | NLRP3 | F2RL3 | STING1 | NF-kappaB (NFkB) | F11 | CXCL8 | KLKB1 | GP6 | CYP4F2 | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | NADPH Oxidase Complex | CRBN | Gap Junction Protein (nonspecified subtype) | Cyclin A (nonspecified subtype) | CCL2 | HLA-DQB1 | Nitric oxide synthase (NOS) (nonspecified subtype) | Intrinsic Tenase Complex | CTSB | F2R | ALOX5 | PDIA3 | HSD17B1 | Angiotensin receptor (AT) (nonspecified subtype) | NQO1 | GJD2 | Sphingolipid delta(4)-desaturase (nonspecified subtype) | Potassium Channels (nonspecified subtype) | Integrin alpha1beta1 (VLA-1) receptor | Vascular endothelial growth factors (VEGF) (nonspecified subtype) | F7 | Endothelin receptor (nonspecified subtype) | ADRA1B | TBXA2R | MAOB | ABO | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3 (PDE3) (nonspecified subtype) | ABCC4 | SUV39H1 | CDK1 | ABL1 | alpha-Amylase (nonspecified subtype) | TFPI | PIK3CG | FGG | ABCC3 | NADPH Oxidase (nonspecified subtype) | Integrin alphavbeta8 Receptor | HMOX1 | ANPEP | PTPRC | Soluble guanylyl cyclase | CDC42 | DEGS2 | DYRK2 | DEGS1 | SLC29A1 | FGF2 | REN | ATF5 | PLK1 | Integrin alpha2beta1 (VLA-2) receptor | STAT3 | PRKG1 | PTGFR | PTAFR | ODC1 | PI3 | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | PGK1 | MPO | SRC | PDE4D | RHOA | THBD | SENP1 | HTR1D | TNF | HIF1A | Phosphodiesterase (nonspecified subtype) | PDE3A | PPT1 | DNA-Dependent Protein Kinase (DNA-PK) | ALOX15 | HTR7 | AMP-activated protein kinase (AMPK) | F8 | TRPM3 | ENPP2 | BTK | SELE | F12 | MAP3K3 | RPS6KA1 | CYBA | RIPK2 | AVPR1A | TP53 | APEH | TBXAS1 | OPRM1 | 5-Hydroxytryptamine Receptor 3 (5-HT3 receptor) (nonspecified subtype) | LDLR | CGAS | KCNJ11 | MIR6886 | STXBP5 | LPAR5 | Fibrinogen | Phosphodiesterase IV (PDE4) (nonspecified subtype) | CDK2 | KRT37 | HLA-DRB1 | Protein farnesyltransferase | CD36 | CNR2 | KCNH2 | ACE | GPR35 | Cyclin B (nonspecified subtype) | CETP | PMM2 | LRRK2 | CYP2C19 | ELANE
Other Diseases
Thrombotic Microangiopathy | Thymoma, Malignant | Thyroid Dysgenesis | Thyroid Dyshormonogenesis | Thyroid Hormone Resistance | Thyroiditis | Thyroiditis, Autoimmune | Thyrotoxic Periodic Paralysis | Tibial Muscular Dystrophy | Tic Disorder | Tietze Syndrome | Tinea | Tinea Versicolor | Tonsillitis | Torticollis | Toxic Epidermal Necrolysis | Toxoplasmosis | Traboulsi Syndrome | Tracheal Disorders | Trachoma | Transcobalamin Deficiency | Transient Bullous Dermolysis Of The Newborn | Transthyretin-related Amyloidosis | Treacher Collins Syndrome | Tremor | Tricho-hepato-enteric Syndrome | Trichomegaly | Trichorhinophalangeal Syndrome | Trichothiodystrophy | Trichotillomania | Trichuriasis | Trigonocephaly | Trimethylaminuria | Triphalangeal Thumb-polysyndactyly Syndrome | Triple A Syndrome | Trismus-pseudocamptodactyly Syndrome | Tuberculosis | Tuberculous Meningitis | Tularemia | Tumoral Calcinosis | Turner's Syndrome | Twin-to-twin Transfusion Syndrome | Tylosis With Esophageal Cancer | Tyrosine Hydroxylase Deficiency | Tyrosinemia | Tyrosinemia Type 1 | Tyrosinemia Type 2 | Ulcerative Colitis | Unverricht-Lundborg Syndrome | Urea Cycle Disorder | Uremia | Uremic Pruritus | Ureteropelvic Junction Obstruction | Urethritis | Urofacial Syndrome | Urolithiasis | Urticaria | Usher Syndrome | Usher Syndrome Type II | Usher Syndrome Type IIC | Usher Syndrome Type III | Uterine Leiomyoma | Uveitis | Uveitis, Anterior | VACTERL Association | VACTERL/VATER Association | Vaginitis | Van Der Knaap Disease | Varicocele | Vascular Calcification | Vascular Cognitive Impairment | Vasculitis | Veno-occlusive Disease | Venous Insufficiency | Ventricular Septal Defect | Vertebrobasilar Insufficiency | Vertigo | Very Long-chain Acyl-CoA Dehydrogenase Deficiency | Vestibular Disease | VEXAS Syndrome | Vici Syndrome | Viral Meningitis | Vitamin A Deficiency | Vitamin B12 Deficiency | Vitamin D Deficiency | Vitamin K Deficiency | Vitelliform Macular Dystrophy | Vitiligo | Vitreoretinal Degeneration, Snowflake Type | Vitreoretinopathy, Proliferative | Vogt-Koyanagi-Harada Syndrome | Von Hippel-Lindau Disease | Von Willebrand Disease | Vulvovaginitis | Waardenburg Syndrome | Waardenburg Syndrome Type 1 | Waardenburg Syndrome Type 2 | Waardenburg Syndrome Type 2A | Waardenburg Syndrome Type 2E | Waardenburg Syndrome Type 4 | Waardenburg Syndrome Type 4A | Wagner Disease | WAGR Syndrome | Waldenstrom Macroglobulinemia | Walker-Warburg Syndrome | Warsaw Breakage Syndrome | Weill-Marchesani Syndrome | Werner's Syndrome | Whipple's Disease | Wieacker-Wolff Syndrome | Wiedemann-Steiner Syndrome | Williams Syndrome | Wilson's Disease | Wiskott-Aldrich Syndrome | Withdrawal Syndrome | Wolcott-Rallison Syndrome | Wolff-Parkinson-White Syndrome | Wolfram Syndrome | Wolfram Syndrome 2 | Wolman Disease | Woodhouse-Sakati Syndrome | X-linked Acrogigantism | X-linked Charcot-Marie-Tooth Disease | X-linked Creatine Transporter Deficiency | X-linked Myotubular Myopathy | X-linked Sideroblastic Anemia | Xeroderma Pigmentosum | Xeroderma Pigmentosum Variant Type | Yellow Fever | Zellweger Syndrome | Zimmermann-Laband Syndrome | Zollinger-Ellison Syndrome | Zygomycosis
