Phosphodiesterase (nonspecified subtype) Related Diseases

Phosphodiesterase (nonspecified subtype)

Related Diseases

1) Arthritis
Arthritis, also known as inflammatory joint disease, is related to rheumatoid arthritis and juvenile rheumatoid arthritis, and has symptoms including arthralgia, back pain and metatarsalgia. An important gene associated with Arthritis is SYK (Spleen Associated Tyrosine Kinase), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Entecavir and Chlorhexidine have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and bone marrow, and related phenotypes are Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression and homeostasis/metabolism

2) Huntington's Disease
Huntington Disease, also known as huntington's disease, is related to huntington disease-like 1 and choreatic disease, and has symptoms including back pain, headache and myoclonus. An important gene associated with Huntington Disease is HTT (Huntingtin), and among its related pathways/superpathways is miRNAs involved in DNA damage response. The drugs Memantine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include Brain, eye and globus pallidus, and related phenotypes are chorea and mental deterioration

3) Stroke, Ischemic
Stroke, Ischemic, also known as cerebral infarction, is related to sneddon syndrome and brain small vessel disease 1, and has symptoms including angina pectoris, back pain and chest pain. An important gene associated with Stroke, Ischemic is F5 (Coagulation Factor V), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Diseases of hemostasis. The drugs Heparin, bovine and Nadroparin have been mentioned in the context of this disorder. Affiliated tissues include Bone and Brain, and related phenotypes are stroke and homeostasis/metabolism

4) Major Depression
Major Depressive Disorder, also known as seasonal affective disorder, is related to anxiety and endogenous depression, and has symptoms including affective symptoms, behavioral symptoms and schizophrenic language. An important gene associated with Major Depressive Disorder is HTR2A (5-Hydroxytryptamine Receptor 2A), and among its related pathways/superpathways are Signal Transduction and Neuroscience. The drugs Fluvoxamine and Valsartan have been mentioned in the context of this disorder. Affiliated tissues include brain, prefrontal cortex and cortex, and related phenotypes are depression and behavior/neurological

5) Diabetes Type 2
Type 2 Diabetes Mellitus, also known as insulin resistance, is related to diabetes mellitus and maturity-onset diabetes of the young, type 8, with exocrine dysfunction, and has symptoms including angina pectoris, tremor and equilibration disorder. An important gene associated with Type 2 Diabetes Mellitus is IRS1 (Insulin Receptor Substrate 1), and among its related pathways/superpathways are Nervous system development and Angiopoietin-like protein 8 regulatory pathway. The drugs Glipizide and Glycopyrronium have been mentioned in the context of this disorder. Affiliated tissues include Pancreas and Adipose, and related phenotypes are type ii diabetes mellitus and insulin resistance

6) Erectile Dysfunction
Impotence, also known as erectile dysfunction, is related to vasculogenic impotence and prolactinoma, and has symptoms including angina pectoris, pelvic pain and tremor. An important gene associated with Impotence is PDE5A (Phosphodiesterase 5A), and among its related pathways/superpathways are Signal Transduction and MIF Mediated Glucocorticoid Regulation. The drugs Selegiline and Nebivolol have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, prostate and spinal cord, and related phenotypes are no effect and no effect

7) Primary Biliary Cholangitis
Primary Biliary Cholangitis, also known as primary biliary cirrhosis, is related to gastrointestinal system disease and non-alcoholic fatty liver disease. An important gene associated with Primary Biliary Cholangitis is PBC2 (Biliary Cirrhosis, Primary, 2), and among its related pathways/superpathways are miRNAs involved in DNA damage response and Cell differentiation - expanded index. The drugs Abatacept and Meropenem have been mentioned in the context of this disorder. Affiliated tissues include Umbilical Cord, liver and bone, and related phenotypes are cirrhosis and biliary cirrhosis

8) Peripheral Neuropathy
Neuropathy, also known as peripheral neuropathy, is related to neuropathy, hereditary, with liability to pressure palsies and neuropathy, hereditary sensory and autonomic, type iia, and has symptoms including back pain, headache and neuralgia. An important gene associated with Neuropathy is DLX6-AS1 (DLX6 Antisense RNA 1), and among its related pathways/superpathways are Neural crest differentiation and EGR2 and SOX10-mediated initiation of Schwann cell myelination. The drugs Capsaicin and Mexiletine have been mentioned in the context of this disorder. Affiliated tissues include nerves, dorsal root ganglion and bone marrow, and related phenotypes are no effect and no effect

9) Asthma
Asthma, also known as chronic obstructive asthma, is related to allergic asthma and childhood-onset asthma, and has symptoms including recurring periods of wheezing, chest tightness and shortness of breath. An important gene associated with Asthma is IL13 (Interleukin 13), and among its related pathways/superpathways are Allograft rejection and Interleukin-4 and Interleukin-13 signaling. The drugs Fentanyl and Etomidate have been mentioned in the context of this disorder. Affiliated tissues include Lung, smooth muscle and skin, and related phenotypes are asthma and bronchoconstriction

10) Multiple Sclerosis
Multiple Sclerosis, also known as ms, is related to pediatric multiple sclerosis and autoimmune hepatitis, and has symptoms including back pain, headache and hemiplegia. An important gene associated with Multiple Sclerosis is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Phosphorylation of CD3 and TCR zeta chains and Cell differentiation - expanded index. The drugs Acetaminophen and Promethazine have been mentioned in the context of this disorder. Affiliated tissues include Neural Tube and Limb, and related phenotypes are spasticity and diplopia

11) Parkinson's Disease
Parkinson Disease, Late-Onset, also known as parkinson disease, is related to hereditary late-onset parkinson disease and parkinson disease 3, autosomal dominant, and has symptoms including angina pectoris, back pain and headache. An important gene associated with Parkinson Disease, Late-Onset is MAPT (Microtubule Associated Protein Tau), and among its related pathways/superpathways is Parkinson's disease pathway. The drugs Idebenone and Tadalafil have been mentioned in the context of this disorder. Affiliated tissues include Brain, and related phenotypes are hallucinations and abnormal autonomic nervous system physiology

12) Angina Pectoris
Angina Pectoris, also known as prinzmetal's variant angina, is related to polycythemia vera and intermittent claudication, and has symptoms including other and unspecified angina pectoris An important gene associated with Angina Pectoris is EDN1 (Endothelin 1), and among its related pathways/superpathways are Signal Transduction and Response to elevated platelet cytosolic Ca2+. The drugs Candesartan cilexetil and Amiodarone have been mentioned in the context of this disorder. Affiliated tissues include heart, smooth muscle and bone marrow, and related phenotypes are homeostasis/metabolism and muscle

13) Myocardial Infarction
Myocardial Infarction, also known as heart attack, is related to lipoprotein quantitative trait locus and cardiovascular system disease, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Myocardial Infarction is MIAT (Myocardial Infarction Associated Transcript), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway. The drugs Miconazole and Clotrimazole have been mentioned in the context of this disorder. Affiliated tissues include Bone and Limb.

14) Heart Failure
Congestive Heart Failure, also known as congestive heart disease, is related to cardiomyopathy, dilated, 1e and orthostatic intolerance, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Congestive Heart Failure is CDKN2B-AS1 (CDKN2B Antisense RNA 1), and among its related pathways/superpathways are Cardiac conduction and "Antiarrhythmic Pathway, Pharmacodynamics". The drugs Salbutamol and Thalidomide have been mentioned in the context of this disorder. Affiliated tissues include Adipose and Lateral Plate Mesoderm, and related phenotypes are muscle and homeostasis/metabolism

15) Chronic Kidney Disease
Chronic Kidney Disease, also known as chronic renal disease, is related to kidney disease and end stage renal disease, and has symptoms including cloudy (hemodialysis) (peritoneal) dialysis effluent An important gene associated with Chronic Kidney Disease is COL4A4 (Collagen Type IV Alpha 4 Chain), and among its related pathways/superpathways are Signal Transduction and Primary focal segmental glomerulosclerosis (FSGS). The drugs Chlorhexidine and Fosinopril have been mentioned in the context of this disorder. Affiliated tissues include Bone and Adipose, and related phenotypes are homeostasis/metabolism and renal/urinary system

16) Alopecia Areata
Alopecia Areata, also known as alopecia circumscripta, is related to alopecia universalis congenita and alopecia, and has symptoms including exanthema and pruritus. An important gene associated with Alopecia Areata is AA1 (Alopecia Areata 1), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Cetirizine and Histamine have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and t cells, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

17) Duchenne Muscular Dystrophy
Muscular Dystrophy, Duchenne Type, also known as duchenne muscular dystrophy, is related to muscular dystrophy, becker type and facioscapulohumeral muscular dystrophy 1, and has symptoms including waddling gait and weakness. An important gene associated with Muscular Dystrophy, Duchenne Type is DMD (Dystrophin), and among its related pathways/superpathways are Cell differentiation - expanded index and miRNAs involvement in the immune response in sepsis. The drugs Carvedilol and Ramipril have been mentioned in the context of this disorder. Affiliated tissues include Adipose and Umbilical Cord, and related phenotypes are scoliosis and respiratory insufficiency

18) Depression
Major Depressive Disorder, also known as seasonal affective disorder, is related to anxiety and endogenous depression, and has symptoms including affective symptoms, behavioral symptoms and schizophrenic language. An important gene associated with Major Depressive Disorder is HTR2A (5-Hydroxytryptamine Receptor 2A), and among its related pathways/superpathways are Signal Transduction and Neuroscience. The drugs Fluvoxamine and Valsartan have been mentioned in the context of this disorder. Affiliated tissues include brain, prefrontal cortex and cortex, and related phenotypes are depression and behavior/neurological

19) Inflammatory Bowel Disease
Inflammatory Bowel Disease, also known as inflammatory bowel diseases, is related to inflammatory bowel disease 6 and inflammatory bowel disease 9. An important gene associated with Inflammatory Bowel Disease is IL37 (Interleukin 37). The drugs Copper and Zinc cation have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and bone marrow.

20) Anxiety Disorders
Anxiety, also known as anxiety disorders, is related to generalized anxiety disorder and separation anxiety disorder, and has symptoms including nervousness, agitation and feeling tense. An important gene associated with Anxiety is SLC6A4 (Solute Carrier Family 6 Member 4), and among its related pathways/superpathways are Signal Transduction and Class A/1 (Rhodopsin-like receptors). The drugs Amlodipine and Lorazepam have been mentioned in the context of this disorder. Affiliated tissues include brain, breast and thyroid, and related phenotypes are nervous system and normal

21) Idiopathic Pulmonary Fibrosis
Acute Interstitial Pneumonia, also known as acute interstitial pneumonitis, is related to mikulicz disease and pulmonary fibrosis, and has symptoms including dyspnea on exertion and dry cough. An important gene associated with Acute Interstitial Pneumonia is SFTPD (Surfactant Protein D), and among its related pathways/superpathways are Disease and Innate Immune System. The drugs Nintedanib and Protein Kinase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include lung, bone marrow and bone, and related phenotypes are dyspnea and respiratory failure

22) Malaria
Malaria, also known as malaria, susceptibility to, is related to plasmodium falciparum malaria and plasmodium vivax malaria, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Malaria is SLC4A1 (Solute Carrier Family 4 Member 1 (Diego Blood Group)), and among its related pathways/superpathways are Innate Immune System and Response to elevated platelet cytosolic Ca2+. The drugs Lumefantrine and Artemether have been mentioned in the context of this disorder. Affiliated tissues include spleen, liver and t cells, and related phenotypes are nausea and vomiting and fever

23) Pain
Paine Syndrome, also known as pain disorder, is related to paroxysmal extreme pain disorder and indifference to pain, congenital, autosomal recessive. An important gene associated with Paine Syndrome is HFE (Homeostatic Iron Regulator), and among its related pathways/superpathways are Cardiac conduction and Neuropathic Pain-Signaling in Dorsal Horn Neurons. The drugs Pregabalin and Dinoprostone have been mentioned in the context of this disorder. Affiliated tissues include dorsal root ganglion, spinal cord and breast, and related phenotypes are microcephaly and spastic diplegia

24) Hemorrhoids
Hemorrhoid, also known as hemorrhoids, is related to mucormycosis and internal hemorrhoid, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Hemorrhoid is APC (APC Regulator Of WNT Signaling Pathway), and among its related pathways/superpathways are Alzheimer's disease and miRNA effects and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The drugs Menthol and Borage oil have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and spinal cord, and related phenotypes are neoplasm and muscle

25) Behcet's Disease
Behcet Syndrome, also known as behcet disease, is related to vogt-koyanagi-harada disease and spondyloarthropathy 1, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Behcet Syndrome is MEFV (MEFV Innate Immunity Regulator, Pyrin), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Fluocinolone acetonide and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, eye and skin, and related phenotypes are nausea and vomiting and arthritis

26) Vertigo
Central Nervous System Origin Vertigo, also known as vertigo of central origin, is related to sneddon syndrome and cerebrovascular disease, and has symptoms including dizziness, nausea and vomiting. An important gene associated with Central Nervous System Origin Vertigo is CACNA1A (Calcium Voltage-Gated Channel Subunit Alpha1 A), and among its related pathways/superpathways are Diseases of hemostasis and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The drugs Calcium carbonate and Dimenhydrinate have been mentioned in the context of this disorder. Affiliated tissues include cerebellum, brain and liver, and related phenotypes are homeostasis/metabolism and growth/size/body region

27) Necrobiosis Lipoidica
Necrobiosis Lipoidica, also known as oppenheim-urbach disease, is related to renal glucosuria and tuberculoid leprosy. An important gene associated with Necrobiosis Lipoidica is CD163 (CD163 Molecule), and among its related pathways/superpathways are Hematopoietic Stem Cells and Lineage-specific Markers and Roles of ceramides in the development of insulin resistance. Affiliated tissues include skin, neutrophil and thyroid, and related phenotypes are inflammatory abnormality of the skin and annular cutaneous lesion

28) Rheumatoid Arthritis
Rheumatoid Arthritis, also known as ra, is related to arthritis and psoriatic arthritis, and has symptoms including back pain, muscle cramp and sciatica. An important gene associated with Rheumatoid Arthritis is PTPN22 (Protein Tyrosine Phosphatase Non-Receptor Type 22), and among its related pathways/superpathways are NF-kappaB Signaling and Genes associated with the development of rheumatoid arthritis. The drugs Entecavir and Alendronic acid have been mentioned in the context of this disorder. Affiliated tissues include Cartilage, joint and bone, and related phenotypes are joint stiffness and fatigue

29) Schizophrenia
Schizophrenia, also known as schizophrenia with or without an affective disorder, is related to schizoaffective disorder and psychotic disorder, and has symptoms including sleep disturbances, photophobia and personality changes. An important gene associated with Schizophrenia is RTN4R (Reticulon 4 Receptor), and among its related pathways/superpathways are "Methylphenidate Pathway, Pharmacodynamics" and MTHFR deficiency. The drugs Molindone and Asenapine have been mentioned in the context of this disorder. Affiliated tissues include brain, prefrontal cortex and cortex, and related phenotypes are eeg abnormality and hallucinations

30) Diabetes
Diabetes Mellitus, also known as diabetes, is related to type 2 diabetes mellitus and gestational diabetes, and has symptoms including angina pectoris, tremor and equilibration disorder. An important gene associated with Diabetes Mellitus is KCNJ11 (Potassium Inwardly Rectifying Channel Subfamily J Member 11), and among its related pathways/superpathways are Regulation of beta-cell development and Cell differentiation - expanded index. The drugs Miconazole and Clotrimazole have been mentioned in the context of this disorder. Affiliated tissues include pancreas, bone marrow and kidney.

31) Diabetic Nephropathy
Microvascular Complications of Diabetes 2, also known as microvascular complications of diabetes, susceptibility to, 2, is related to microvascular complications of diabetes 3 and background diabetic retinopathy. An important gene associated with Microvascular Complications of Diabetes 2 is EPO (Erythropoietin). The drugs Mecobalamin and Hydroxocobalamin have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and retina.

32) Fibrosis
Fibrosis of Extraocular Muscles, Congenital, 1, also known as fibrosis of extraocular muscles, congenital, 3b, is related to moebius syndrome and fibrosis of extraocular muscles, congenital, 2, and has symptoms including cachexia, cyanosis and dyspnea. An important gene associated with Fibrosis of Extraocular Muscles, Congenital, 1 is KIF21A (Kinesin Family Member 21A), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and Vesicle-mediated transport. The drugs Angiotensin II and Losartan have been mentioned in the context of this disorder. Affiliated tissues include liver, eye and bone marrow, and related phenotypes are esotropia and exotropia

33) Conjunctivitis, Allergic
Allergic Conjunctivitis, also known as perennial allergic conjunctivitis, is related to vernal keratoconjunctivitis and giant papillary conjunctivitis. An important gene associated with Allergic Conjunctivitis is HRH1 (Histamine Receptor H1), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Hyaluronic acid and Tacrolimus have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and thymus, and related phenotypes are homeostasis/metabolism and immune system

34) Sarcoidosis
Sarcoidosis 2, also known as sarcoidosis, susceptibility to, 2, is related to blau syndrome and neurosarcoidosis, and has symptoms including coughing and snoring. An important gene associated with Sarcoidosis 2 is BTNL2 (Butyrophilin Like 2). The drugs Azathioprine and Pirfenidone have been mentioned in the context of this disorder. Affiliated tissues include lung, spleen and lymph node, and related phenotypes are bronchiectasis and pleural effusion

35) Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex 1, also known as guam disease, is related to frontotemporal dementia and/or amyotrophic lateral sclerosis 3 and frontotemporal dementia and/or amyotrophic lateral sclerosis 2, and has symptoms including tremor, bradykinesia and abnormality of extrapyramidal motor function. An important gene associated with Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex 1 is TRPM7 (Transient Receptor Potential Cation Channel Subfamily M Member 7), and among its related pathways/superpathways are Neuroscience and Copper homeostasis. The drugs Varenicline and Riluzole have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, spinal cord and brain, and related phenotypes are muscle weakness and dementia

36) Cirrhosis
Liver Cirrhosis, also known as cirrhosis, is related to alcoholic liver cirrhosis and primary biliary cholangitis, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Liver Cirrhosis is FARSB (Phenylalanyl-TRNA Synthetase Subunit Beta), and among its related pathways/superpathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Lung fibrosis. The drugs Racivir and Propofol have been mentioned in the context of this disorder. Affiliated tissues include Bone and Blood.

37) Hepatopulmonary Syndrome
Hepatopulmonary Syndrome is related to portal hypertension and pulmonary hypertension, primary, 1, and has symptoms including hemoptysis An important gene associated with Hepatopulmonary Syndrome is ALB (Albumin), and among its related pathways/superpathways are MIF Mediated Glucocorticoid Regulation and Signal Transduction. The drugs Norfloxacin and Letrozole have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and brain, and related phenotypes are no effect and no effect

38) Liver Diseases
Liver Disease, also known as liver diseases, is related to non-alcoholic fatty liver disease and fatty liver disease, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Liver Disease is MEG3 (Maternally Expressed 3), and among its related pathways/superpathways are Metabolism and Nuclear receptors meta-pathway. The drugs Perindopril and Amlodipine have been mentioned in the context of this disorder. Affiliated tissues include liver, bone marrow and kidney, and related phenotypes are Reduced mammosphere formation and liver/biliary system

39) Obesity
Body Mass Index Quantitative Trait Locus 11, also known as obesity, is related to leptin deficiency or dysfunction and type 2 diabetes mellitus, and has symptoms including high weight, symptoms and obesity, metabolically benign. An important gene associated with Body Mass Index Quantitative Trait Locus 11 is UCP3 (Uncoupling Protein 3), and among its related pathways/superpathways are Beta-2 adrenergic-dependent CFTR expression and Glucose / Energy Metabolism. The drugs Hydrocortisone and Hydrocortisone succinate have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, liver and heart, and related phenotypes are obesity and decreased resting energy expenditure

40) Glomerulonephritis
Glomerulonephritis, also known as bright's disease, is related to c3 glomerulopathy and membranous nephropathy. An important gene associated with Glomerulonephritis is COL4A4 (Collagen Type IV Alpha 4 Chain), and among its related pathways/superpathways are Innate Immune System and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The drugs Mycophenolic acid and Leflunomide have been mentioned in the context of this disorder. Affiliated tissues include Kidney, heart and bone marrow, and related phenotypes are Reduced mammosphere formation and homeostasis/metabolism

41) Nephropathy
Kidney Disease, also known as renal failure, is related to chronic kidney disease and polycystic kidney disease, and has symptoms including polyuria An important gene associated with Kidney Disease is TSC1 (TSC Complex Subunit 1), and among its related pathways/superpathways are Ciliopathies and Bardet-Biedl syndrome. The drugs Amiodarone and Nicotinamide have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and bone marrow, and related phenotypes are homeostasis/metabolism and renal/urinary system

42) Nephrotic Syndrome
Hypoparathyroidism, Sensorineural Deafness, and Renal Dysplasia Syndrome, also known as barakat syndrome, is related to membranoproliferative glomerulonephritis and glomerulonephritis. An important gene associated with Hypoparathyroidism, Sensorineural Deafness, and Renal Dysplasia Syndrome is GATA3 (GATA Binding Protein 3), and among its related pathways/superpathways are Cell junction organization and Primary focal segmental glomerulosclerosis (FSGS). The drugs Entecavir and Furosemide have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and uterus, and related phenotypes are hypoparathyroidism and renal dysplasia

43) Pancreatitis
Acute Pancreatitis, also known as pancreatitis, acute necrotizing, is related to pancreatitis, hereditary and igg4-related disease. An important gene associated with Acute Pancreatitis is CPB1 (Carboxypeptidase B1), and among its related pathways/superpathways are Sudden infant death syndrome (SIDS) susceptibility pathways and CCL18 signaling pathway. The drugs Cefoperazone and Acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include pancreas, bone marrow and liver, and related phenotypes are no effect and no effect

44) Cerebrovascular Disorders
Cerebrovascular Disease, also known as cerebrovascular disorder, is related to basal ganglia cerebrovascular disease and stroke, ischemic, and has symptoms including headache, transient ischemic attacks, stereotypic symptoms and angina pectoris. An important gene associated with Cerebrovascular Disease is HOTAIR (HOX Transcript Antisense RNA), and among its related pathways/superpathways are Signal Transduction and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The drugs Acetylcarnitine and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include brain, bone marrow and heart, and related phenotypes are homeostasis/metabolism and growth/size/body region

45) Autism Spectrum Disorders
Autism Spectrum Disorder, also known as autism spectrum disorders, is related to autism and attention deficit-hyperactivity disorder, and has symptoms including widespread abnormalities of social interactions, severely restricted interests and highly repetitive behavior. An important gene associated with Autism Spectrum Disorder is SHANK2 (SH3 And Multiple Ankyrin Repeat Domains 2), and among its related pathways/superpathways are Thyroid hormones production and peripheral downstream signaling effects and Rett syndrome causing genes. The drugs Acetylcholine and Dexmedetomidine have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and prefrontal cortex, and related phenotypes are nervous system and growth/size/body region

46) AIDS
Acquired Immunodeficiency Syndrome, also known as acquired immune deficiency syndrome, is related to human immunodeficiency virus type 1 and aids dementia complex. An important gene associated with Acquired Immunodeficiency Syndrome is HCP5 (HLA Complex P5), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Ethambutol and Pyrazinamide have been mentioned in the context of this disorder. Affiliated tissues include t cells, breast and bone marrow, and related phenotypes are neoplasm and endocrine/exocrine gland

47) Thrombosis
Complement Hyperactivation, Angiopathic Thrombosis, and Protein-Losing Enteropathy, also known as chaple, is related to blood group, cromer system and protein-losing enteropathy. An important gene associated with Complement Hyperactivation, Angiopathic Thrombosis, and Protein-Losing Enteropathy is CD55 (CD55 Molecule (Cromer Blood Group)). The drugs Dabigatran and Norethisterone have been mentioned in the context of this disorder. Affiliated tissues include liver, whole blood and endothelial, and related phenotypes are thrombocytosis and hepatomegaly

48) Dyslipidemia
Lipid Metabolism Disorder, also known as dyslipidemia, is related to hyperlipoproteinemia, type iii and hypobetalipoproteinemia, familial, 1. An important gene associated with Lipid Metabolism Disorder is LIPC (Lipase C, Hepatic Type), and among its related pathways/superpathways are Metabolism and Transport of inorganic cations/anions and amino acids/oligopeptides. The drugs Tocopherol and Aripiprazole have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and bone marrow, and related phenotypes are no effect and no effect

49) Psoriasis
Psoriasis is related to psoriasis 7 and psoriasis 10, and has symptoms including exanthema, pruritus and psoriasiform rash. An important gene associated with Psoriasis is MIR203A (MicroRNA 203a), and among its related pathways/superpathways are miRNAs involvement in the immune response in sepsis and Cell differentiation - expanded index. The drugs Metformin and Vedolizumab have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and endothelial.

50) Intermittent Claudication
Intermittent Claudication, also known as amyotrophic lateral sclerosis, is related to peripheral artery disease and angina pectoris, and has symptoms including back pain, headache and pain. An important gene associated with Intermittent Claudication is SELP (Selectin P), and among its related pathways/superpathways are Signal Transduction and ERK Signaling. The drugs Vorapaxar and Thrombin have been mentioned in the context of this disorder. Affiliated tissues include Placenta, bone marrow and spinal cord, and related phenotypes are no effect and no effect

51) Osteoarthritis
Osteoarthritis, also known as osteoarthrosis, is related to cartilage disease and exostosis, and has symptoms including arthralgia, back pain and metatarsalgia. An important gene associated with Osteoarthritis is HOTAIR (HOX Transcript Antisense RNA), and among its related pathways/superpathways are ECM proteoglycans and Extracellular matrix organization. The drugs Fentanyl and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include Cartilage and Bone, and related phenotype is limbs/digits/tail.

52) Osteonecrosis
Osteonecrosis, also known as bone necrosis, is related to osteonecrosis of the jaw and osteomyelitis, and has symptoms including back pain, muscle cramp and sciatica. An important gene associated with Osteonecrosis is BGLAP (Bone Gamma-Carboxyglutamate Protein), and among its related pathways/superpathways are Signal Transduction and Extracellular matrix organization. The drugs Pentoxifylline and Tocopherol have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and skin, and related phenotypes are homeostasis/metabolism and growth/size/body region

53) Hypertension
Hypertension, Essential, also known as essential hypertension, is related to pulmonary hypertension and renovascular hypertension, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Hypertension, Essential is PTGIS (Prostaglandin I2 Synthase), and among its related pathways/superpathways are Development Angiotensin activation of ERK and "Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics". The drugs Digoxin and Warfarin have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and eye, and related phenotypes are elevated systolic blood pressure and elevated diastolic blood pressure

54) Hypertension, Pulmonary
Pulmonary Hypertension, also known as primary pulmonary hypertension, is related to pulmonary hypertension, primary, 1 and persistent fetal circulation syndrome, and has symptoms including angina pectoris, chest pain and coughing. An important gene associated with Pulmonary Hypertension is BMPR2 (Bone Morphogenetic Protein Receptor Type 2), and among its related pathways/superpathways are MicroRNAs in cardiomyocyte hypertrophy and miRNAs involved in DNA damage response. The drugs Morphine and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include Lung, heart and endothelial, and related phenotypes are muscle and cardiovascular system

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