Ulcerative Colitis
About the Disease
Inflammatory Bowel Disease 1, also known as inflammatory bowel disease 1, is related to inflammatory bowel disease 19 and inflammatory bowel disease 17, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Inflammatory Bowel Disease 1 is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Innate Immune System and NF-kappaB Signaling. The drugs Magnesium citrate and Prucalopride have been mentioned in the context of this disorder. Affiliated tissues include colon, bone marrow and bone, and related phenotypes are growth delay and abdominal pain
Common Targets / Biomarkers
TNFAIP8 | CATSPER3 | IL1RN | Protein Phosphatase 2A | TLR5 | TNFRSF11B | NPHS1 | GPR35 | TRIM3 | CRYBG1 | LOC105375194 | LOC105379570 | BABAM2 | MALT1 | HSPA5 | PTPN2 | LRRK2 | CCDC26 | OR1N2 | COX2 | MUSK | PIK3R5 | GSR | LOC105375195 | ADCY7 | IL6ST | SCN10A | RALYL | Integrin alpha4beta1 (VLA-4) receptor | Phosphodiesterase IV (PDE4) (nonspecified subtype) | CD24 | CSK | F2RL1 | CACNA2D1 | ZBTB38 | Corticotropin-Releasing Factor (CRF) Receptor (nonspecified subtype) | CREM | ELANE | TRAF1 | LINC01697 | CD247 | CD3 Complex (T Cell Receptor Complex) | MYD88 | PADI4 | LOC105379648 | Tyrosine-Protein Kinases Src (nonspecified subtype) | KIF13A | gamma-Secretase | cAMP Phosphodiesterase (nonspecified subtype) | SLC28A3 | TRAF3IP2-AS1 | TNFSF8 | CNR2 | VWF | MCPH1-AS1 | PADI2 | MYH9 | PDE4B | LOC105379652 | IL37 | TNFRSF25 | CDK4 | SFRP2 | DNAI2 | HORMAD2 | MAFK | IL23A | TMEM175 | MUC19 | LINC00824 | CD27 | CCDC116 | TNFSF14 | CD6 | Kainate Receptor (GluR) (nonspecified subtype) | PGLYRP1 | IFNB1 | IL2RA | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | TP53 | LOC105379658 | CCR6 | ITPR3 | NFE2L2 | MIF-AS1 | ACOT11 | SORBS2 | CDKN2A | AXL | HLA-B | LOC105379663 | TYK2 | FKBP1A | PITPNM2 | CYSLTR1 | CDC37 | SBNO2 | COX3 | ORAI1 | HDAC8 | ANXA3 | HLA-DRB1 | MARK4 | CALD1 | MUC22 | TUBD1 | PNPLA3 | SLCO5A1 | MCU | IFNGR1 | SPHK2 | IDH1 | LTA | NFATC1 | G6PC2 | DPYS | MAPK14 | JMJD7 | MMP3 | DNAH3 | MUC16 | HLA-DQA1 | IRGM | ERAP2 | AMOTL1 | TNF | FCGRT | IL6-AS1 | PRKCA | MAP2K1 | TPMT | CYB561A3 | MYO9B | ZYX | DOK3 | Lipoxygenase (nonspecified subtype) | VPS41 | CD83 | LAG3 | LAMB1 | LCK | WAS | LY75-CD302 | INTS11 | MGLL | ADGRF5 | RUNX3 | IKZF1 | CPLANE1 | KDM4C | TRPM8 | PHTF1 | OAS2 | TJP3 | GAL3ST3 | PTPRZ1 | ERBB3 | FZD1 | ZNF407 | HTR1A | MAP3K5 | SLC39A11 | DHODH | MTOR | CNR1 | IL10RA | MCCC2 | Matrix Metalloproteinase (MMP) (nonspecified subtype) | Calcium release-activated channel (CRAC) | ANKS1A | PPARG | CCDC85B | SOX17 | C-X-C Chemokine Receptor CXCR1/CXCR2 (IL-8 Receptor) (nonspecified subtype) | OR2G6 | NOTCH1 | CLEC4A | BMP2 | DAP | SYNPO2 | KEAP1 | MYO10 | PPP3R2 | ADCY3 | Mucin (nonspecified subtype) | CGNL1 | GPR18 | CNTNAP5 | KRT72 | LRRK1 | HDAC7 | TNFRSF18 | CDKAL1 | ICAM1 | ITIH4 | SIRT1 | PDE10A | ND1 | TSPAN14 | Integrin alpha4beta7 (LPAM-1) receptor | KRT4 | TG | MICALCL | CPA6 | THBS3 | FPR1 | EED | LINC02888 | PROCR | PLCL1 | QRICH1 | PPP3CC | SP140 | HTR2B | IL7R | SSTR3 | TBX21 | ADP-Ribosyl Cyclase/cyclic ADP-Ribose Hydrolase (ADPRC) (nonspecified subtype) | PPID | CKAP4 | ADAM17 | GNG7 | Alkaline Phosphatase (ALP) (nonspecified subtype) | NOD2 | ATP6V1G2 | CD14 | BTNL2 | PTGS1 | TRPV1 | CCDC88B | PACS1 | ARIH2 | CARD9 | GABA(A) receptor | TJP1 | FARSA | UBE2I | IKBKG | PLK3 | IL12RB1 | MORC4 | TRPV2 | S1PR4 | MAP3K8 | IL17REL | TUBA4A | NAV1 | PTDSS2 | HLA-A | CXCR1 | IL-2 receptor | KCNJ1 | LOC105371082 | CD86 | NR4A1 | CACNA1C | TNFSF10 | KDELR3 | SMPD1 | AFP | DSG3 | NEUROG1 | KIF21B | MCF2L | ALPK1 | CDH17 | CD40 | KCNN4 | SLC9A3 | DUSP16 | OR1L1 | NAT1 | ABCG2 | IL-4 receptor | THEMIS | DPP4 | ATG16L1 | TIRAP | MAPK12 | alpha-Adrenoceptor (nonspecified subtype) | NR1I2 | CDH15 | ZNF597 | Acetylcholine Receptors (Nicotinic) (nAChR) (nonspecified subtype) | LY75 | NR5A2 | SOD2 | UBE2L3 | AGR2 | Nicotinic alpha3beta4 Receptor | SYK | CARS2 | LPXN | HSPE1 | IL17A | SFRP4 | Integrin alphaEbeta7 receptor | Tubulin | NR3C1 | HPGD | ABCC2 | PGAM5-KEAP1-NRF2 Complex | FOSL2-AS1 | IL17RD | CDH1 | DYTN | F10 | VCAM1 | PHLDB1 | CCHCR1 | CD48 | GPX1 | MOSPD2 | MMEL1 | TM6SF2 | IL15 | LACC1 | NCF4 | MIR3936HG | PIWIL4-AS1 | CD38 | Nicotinic alpha4beta2 receptor | TIAM1 | AKR1B1 | TRAPPC9 | NAV2 | TOPORS | GSTT1 | PTPN1 | Histone acetyltransferase (HAT) (nonspecified subtype) | BBS12 | Voltage-Gated Sodium Channel Complex | SMAD7 | FBXO3 | FCGR3A | HHIPL1 | CYP24A1 | TSC22D4 | ULK4 | ATXN2L | INS | MCPH1 | IFNGR2 | ADAM23 | TET2 | FIBP | AGPAT1 | HLA-DRA | XDH | PIK3CA | CLEC2D | DNMT3B | XKR6 | PTGS2 | RIT1 | F2 | IRAK4 | SLC44A4 | TDRD1 | IL12RB2 | Interleukin-12 (IL-12) | S1PR3 | TLR2 | MMP9 | ROBO4 | ITGA4 | SLC16A1 | MIR124-1 | ZAP70 | TAS1R1 | SFMBT1 | DLK1 | FFAR2 | SLC22A23 | MAP3K13 | PXDN | IL27 | DNAH1 | GCKR | ADAMTSL1 | CRPPA | XRCC3 | FKBP5 | TUBB6 | TTC33 | TSLP | LOC105371388 | MUC15 | LINC01104 | APBA2 | CDK6/Cyclin D1 | SMPD2 | MET | UBASH3A | NR1H4 | CCL11 | DOCK5 | DENND1B | ABCB1 | ERMAP | SSTR4 | ASPSCR1 | LOC105374211 | HSPA6 | MAP4K1 | BACH2 | ADORA3 | Sodium channel (nonspecified subtype) | FOSL2 | ZGPAT | BIN1 | PTGER4 | UBAC2 | SOX5 | SPDL1 | HIVEP1 | IL-6 receptor | HELT | VDR | PRKCD | MS4A1 | SIGIRR | S100A8 | ND3 | GPX2 | QARS1 | IL1R1 | LSP1 | CCT5 | AHNAK | CLDN10 | NPY4R | KRT12 | EIF5A | Interferon alpha/beta Receptor (nonspecified subtype) | CDKN2A-DT | TNP1 | ERBB2 | JAZF1 | WFS1 | G6PC1 | BLTP1 | BCL2A1 | GRK4 | C3orf84 | CTLA4 | Glycogen synthase kinase 3 (GSK-3) (nonspecified subtype) | SLC16A2 | SMAD2 | GPATCH8 | ANKRD55 | MLF1 | VNN1 | KIF5C | TMX1 | Toll-Like Receptor (nonspecified subtype) | FLT3 | MAGI3 | BCL2L11 | RC3H2 | LILRA3 | STAT4 | FAAH | GPR84 | WDR49 | FASN | NFKBIL1 | HDAC4 | IL17F | IL2 | Caspase (nonspecified subtype) | FGF10 | LOC105369736 | PRKDC | LHX9 | PREX1 | MMP2 | ESYT1 | NOL10 | HDAC9 | BICD1 | CYP3A5 | NOS3 | MAML2 | SELPLG | CDON | IL1A | IL10 | FGD5 | SLC6A4 | EGFR | EPX | RNF186 | IL18RAP | STK17B | RAD51 | CNN3 | NUAK1 | AP-1 Transcription Factor Complex | PA2G4 | LOC285626 | RNF5 | Polycomb Repressive Complex 2 | PPP5C | CCR9 | Heat shock protein 70 (nonspecified subtype) | SIK2 | CD80 | MUC2 | RGS14 | PELI1 | SYMPK | F5 | FASLG | PRUNE2 | SFTPD | MIR193A | PP7080 | GBA3 | OR10R2 | PRKCB | KIR2DL1 | AHR | ND4 | CLDN2 | Sterol O-acyltransferase (ACAT) (nonspecified subtype) | IFNG | Glycine receptor | DAG1 | TLR9 | ANAPC1 | MAP2K2 | SLC22A4 | MIR124-3 | KCNH3 | DHX32 | SFRP5 | NMDA receptor | TPH1 | VEGFA | CA2 | ANO9 | Tryptase (nonspecified subtype) | NFKBIZ | Janus Kinase (nonspecified subtype) | GGA2 | OAZ1 | KAT6B | CYP26B1 | RNASE3 | FPR2 | TRAIP | HRH1 | CXCR2 | NOS2 | PTPN22 | GDF6 | S1PR5 | ERGIC1 | IL12A | TRPA1 | SLC2A14 | Ikzf1 | GAA | CYTH1 | VHL | CDHR1 | HINT3 | Histone deacetylase (nonspecified subtype) | ERAP1 | SPHK1 | NKX2-3 | MGMT | FHIP1B | LINC01430 | IL1B | INSC | LINC03040 | IL1RL2 | CLEC10A | FCGR2A | PDE11A | FAM98A | SLCO4A1 | Coagulation Factor XIII | MIR146A | TACR1 | CRISPLD2 | ZBTB26 | CCR5 | CXCL10 | ND4L | TNFRSF4 | GLUL | BSN | GSTP1 | ZNF77 | KIR2DL2 | FGFBP2 | PPP3CB | SSTR5 | OSM | PLAU | CDX1 | GSTM1 | HGF | AKR1B10 | APC | PGLYRP2 | NXPE1 | PPL | BCKDK | CCL20 | SLCO1B1 | C1GALT1 | EXOC3-AS1 | PGLYRP3 | IL6 | PLA2G2D | NXPE4 | PPP3R1 | SLC16A3 | SLC30A9 | SERPINA12 | CNBD1 | SMAD3 | INAVA | PRKCQ | ALB | CCDC89 | PDE4A | GLP2R | LOC105376548 | CLDN4 | SECISBP2 | TMEM45A | IL4 | SLC50A1 | LINC02752 | BORCS5 | MIF | FUT10 | PKP1 | TNFSF15 | Phospholipase A2, Secretory (sPLA2) (nonspecified subtype) | C5AR1 | NASP | PARD3 | IL21 | TGM6 | SYPL1 | CRB1 | POLR2C | MAGI1 | GUCY2C | NFILZ | BIRC5 | STING1 | NLRP3 Inflammasome | Intrinsic Tenase Complex | EGLN1 | OSMR | ENTR1 | HNF4A | F11 | GATA3 | HS1BP3 | DMBT1 | P2RX7 | CMKLR1 | KLKB1 | FTO | SLC22A5 | ABCC1 | FUT2 | APOE | JAK3 | LINC01882 | OTOP2 | IL6R | Sphingolipid delta(4)-desaturase (nonspecified subtype) | JAK2 | SNAPC4 | NAAA | JAK1 | CRBN | ORMDL3 | CHORDC1 | TLR6 | TNFRSF8 | KRR1 | MRGPRX2 | CTNNB1 | DEFB1 | DRD3 | F2R | ALOX5 | SLC34A2 | APBA1 | ACSS3 | SOAT2 | CHURC1-FNTB | PMPCA | CXCL8 | ATM | CALCOCO2 | HLA-C | PARK7 | NLRP3 | IL13 | OR52I1 | MANBA | EPRS1 | HCG22 | KAT5 | IFNA1 | TMBIM1 | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3 (PDE3) (nonspecified subtype) | MADCAM1 | ATR | KSR1 | ITGAL | LINC00598 | TNFRSF1A | CPXM2 | MAOB | ASTN2 | ZNF721 | MIR196A2 | C10orf55 | PARD6G | OR1M1 | RFTN2 | NLRX1 | RIPK1 | HLA-DQB1 | CCL24 | S1PR1 | PNKD | USH1C | GPR55 | Serine/Threonine-Protein Kinases SIK (nonspecified subtype) | PIK3CG | TMCO6 | TLR7 | MLH1 | MSH2 | NDFIP1 | MICA | PITX1-AS1 | ABCC10 | DEGS2 | CRP | SOX11 | DTX1 | TMPRSS3 | NF-kappaB (NFkB) | DEGS1 | PTPRC | ZFP90 | LTA4H | LOC105376823 | TRAF3IP2 | CHRNB2 | APOC2 | IL18 | LOC102723364 | CD302 | IRS1 | CT75 | PLK1 | DUOX1 | PRKCE | IL23R | FCGR3B | ZNF583 | MST1 | GPR65 | TAAR1 | Integrin alpha2beta1 (VLA-2) receptor | KCNA2 | MYRF | TFR2 | KLHDC8B | MMP1 | RASGRP4 | SCN5A | FOS | SIK3 | MLLT10 | GRIN2B | PDCD1 | AOC3 | IL22RA1 | ZPBP2 | MIR1247 | TNFRSF9 | TAP2 | PTAFR | Interleukin 23 complex (IL-23) | STAT3 | MUC6 | PRELP | Melanocortin receptor (nonspecified subtype) | FUT3 | GALC | LOC100996583 | LINC02343 | LAMB2P1 | LINC02074 | MPO | BRINP3 | DNA-Dependent Protein Kinase (DNA-PK) | RARS2 | CMA1 | Interleukin-7 receptor | PDE3A | MIR6833 | ADAM30 | PTPN6 | Superoxide dismutase (SOD) (nonspecified subtype) | ZNF831 | IL2RB | SOD1 | LINC02341 | THADA | Peptidyl arginine deiminase (PAD) (nonspecified subtype) | NFKB1 | CNTNAP1 | Glutathione peroxidase (nonspecified subtype) | DNA-Directed DNA Polymerase Complex | IL-23 receptor complex | FRRS1 | TLR1 | DPH5 | RIN2 | PLOD3 | ZMIZ1 | AOAH | GRIN3B | Defensin (nonspecified subtype) | AHRR | SRRD | PDE4D | BANK1 | LOC105370273 | WDR75 | HDAC6 | CD226 | CHRNA5 | XBP1 | RORC | TEAD3 | PPIA | MAGI2 | NICN1 | RIPK2 | IL12B | MC1R | HSP90B1 | CARD8 | NSG2 | PLA2G2A | GNA12 | CCND1 | TUSC3 | CAT | HCK | ACTB | Glutamate Receptor Ionotropic AMPA Receptor | TGFB1 | NEB | TLR8 | Protein Phosphatase 2B | DQX1 | HCG23 | IRF1-AS1 | USP13 | AMP-activated protein kinase (AMPK) | USP4 | IPMK | MACROD2 | TLR4 | OR52N1 | GPATCH1 | HIF1A | OR51L1 | CDK4/Cyclin D1 | CD3G | SLC5A2 | ZNF827 | NPY4R2 | CDH13 | SIRT2 | CHST11 | GDNF | YDJC | TLR3 | GPBAR1 | SMAD4 | LOC101927745 | NDST4 | Interleukin 17 (nonspecified subtype) | LRP6 | IL33 | SLC39A8 | CXCR5 | PUS10 | KIR3DL2 | 5-Hydroxytryptamine Receptor 3 (5-HT3 receptor) (nonspecified subtype)
Other Diseases
Unverricht-Lundborg Syndrome | Urea Cycle Disorder | Uremia | Uremic Pruritus | Ureteropelvic Junction Obstruction | Urethritis | Urofacial Syndrome | Urolithiasis | Urticaria | Usher Syndrome | Usher Syndrome Type II | Usher Syndrome Type IIC | Usher Syndrome Type III | Uterine Leiomyoma | Uveitis | Uveitis, Anterior | VACTERL Association | VACTERL/VATER Association | Vaginitis | Van Der Knaap Disease | Varicocele | Vascular Calcification | Vascular Cognitive Impairment | Vasculitis | Veno-occlusive Disease | Venous Insufficiency | Ventricular Septal Defect | Vertebrobasilar Insufficiency | Vertigo | Very Long-chain Acyl-CoA Dehydrogenase Deficiency | Vestibular Disease | VEXAS Syndrome | Vici Syndrome | Viral Meningitis | Vitamin A Deficiency | Vitamin B12 Deficiency | Vitamin D Deficiency | Vitamin K Deficiency | Vitelliform Macular Dystrophy | Vitiligo | Vitreoretinal Degeneration, Snowflake Type | Vitreoretinopathy, Proliferative | Vogt-Koyanagi-Harada Syndrome | Von Hippel-Lindau Disease | Von Willebrand Disease | Vulvovaginitis | Waardenburg Syndrome | Waardenburg Syndrome Type 1 | Waardenburg Syndrome Type 2 | Waardenburg Syndrome Type 2A | Waardenburg Syndrome Type 2E | Waardenburg Syndrome Type 4 | Waardenburg Syndrome Type 4A | Wagner Disease | WAGR Syndrome | Waldenstrom Macroglobulinemia | Walker-Warburg Syndrome | Warsaw Breakage Syndrome | Weill-Marchesani Syndrome | Werner's Syndrome | Whipple's Disease | Wieacker-Wolff Syndrome | Wiedemann-Steiner Syndrome | Williams Syndrome | Wilson's Disease | Wiskott-Aldrich Syndrome | Withdrawal Syndrome | Wolcott-Rallison Syndrome | Wolff-Parkinson-White Syndrome | Wolfram Syndrome | Wolfram Syndrome 2 | Wolman Disease | Woodhouse-Sakati Syndrome | X-linked Acrogigantism | X-linked Charcot-Marie-Tooth Disease | X-linked Creatine Transporter Deficiency | X-linked Myotubular Myopathy | X-linked Sideroblastic Anemia | Xeroderma Pigmentosum | Xeroderma Pigmentosum Variant Type | Yellow Fever | Zellweger Syndrome | Zimmermann-Laband Syndrome | Zollinger-Ellison Syndrome | Zygomycosis
