Serine protease (nonspecified subtype) Related Diseases

Serine protease (nonspecified subtype)

Related Diseases

1) Arthritis
Arthritis, also known as inflammatory joint disease, is related to rheumatoid arthritis and juvenile rheumatoid arthritis, and has symptoms including arthralgia, back pain and metatarsalgia. An important gene associated with Arthritis is SYK (Spleen Associated Tyrosine Kinase), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Entecavir and Chlorhexidine have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and bone marrow, and related phenotypes are Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression and homeostasis/metabolism

2) Pre-eclampsia
Pre-Eclampsia, also known as preeclampsia, is related to severe pre-eclampsia and eclampsia, and has symptoms including edema, hyperemesis gravidarum and morning sickness. An important gene associated with Pre-Eclampsia is PEE1 (Preeclampsia/Eclampsia 1), and among its related pathways/superpathways are Angiogenesis (CST) and Angiogenesis (WikiPathways). The drugs Azithromycin and Levobupivacaine have been mentioned in the context of this disorder. Affiliated tissues include placenta, kidney and liver, and related phenotypes are hypertension and proteinuria

3) Stroke
Cerebrovascular Disease, also known as cerebrovascular disorder, is related to basal ganglia cerebrovascular disease and stroke, ischemic, and has symptoms including headache, transient ischemic attacks, stereotypic symptoms and angina pectoris. An important gene associated with Cerebrovascular Disease is HOTAIR (HOX Transcript Antisense RNA), and among its related pathways/superpathways are Signal Transduction and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The drugs Acetylcarnitine and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include brain, bone marrow and heart, and related phenotypes are homeostasis/metabolism and growth/size/body region

4) Alpha-1 Antitrypsin Deficiency
Alpha-1-Antitrypsin Deficiency, also known as alpha 1-antitrypsin deficiency, is related to pulmonary disease, chronic obstructive and pulmonary emphysema, and has symptoms including coughing, hemoptysis and snoring. An important gene associated with Alpha-1-Antitrypsin Deficiency is SERPINA1 (Serpin Family A Member 1), and among its related pathways/superpathways are Diseases of hemostasis and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The drugs Pharmaceutical Solutions and Dimercaprol have been mentioned in the context of this disorder. Affiliated tissues include Liver, lung and skin, and related phenotypes are emphysema and hepatic failure

5) Diabetes Type 1
Type 1 Diabetes Mellitus, also known as diabetes mellitus, insulin-dependent, is related to type 1 diabetes mellitus 12 and type 1 diabetes mellitus 5, and has symptoms including polyuria and polydipsia. An important gene associated with Type 1 Diabetes Mellitus is HNF1A (HNF1 Homeobox A), and among its related pathways/superpathways are IL-9 Signaling Pathways and Immune response NFAT in immune response. The drugs Rituximab and Glipizide have been mentioned in the context of this disorder. Affiliated tissues include Bone and Pancreas, and related phenotypes are diabetes mellitus and polydipsia

6) Netherton Syndrome
Netherton Syndrome, also known as comel-netherton syndrome, is related to dermatitis, atopic and ichthyosis, and has symptoms including trichorrhexis invaginata An important gene associated with Netherton Syndrome is SPINK5 (Serine Peptidase Inhibitor Kazal Type 5), and among its related pathways/superpathways are Nervous system development and Collagen chain trimerization. The drugs Serine Proteinase Inhibitors and protease inhibitors have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and heart, and related phenotypes are malabsorption and sparse scalp hair

7) Hemorrhage
Bleeding Disorder, Platelet-Type, 11, also known as glycoprotein vi deficiency, is related to thrombocytopenic purpura, autoimmune and purpura, and has symptoms including abdominal pain, angina pectoris and chest pain. An important gene associated with Bleeding Disorder, Platelet-Type, 11 is GP6 (Glycoprotein VI Platelet), and among its related pathways/superpathways are Signal Transduction and Response to elevated platelet cytosolic Ca2+. The drugs Probucol and Glycerin have been mentioned in the context of this disorder. Affiliated tissues include brain, placenta and whole blood, and related phenotypes are epistaxis and bruising susceptibility

8) Asthma
Asthma, also known as chronic obstructive asthma, is related to allergic asthma and childhood-onset asthma, and has symptoms including recurring periods of wheezing, chest tightness and shortness of breath. An important gene associated with Asthma is IL13 (Interleukin 13), and among its related pathways/superpathways are Allograft rejection and Interleukin-4 and Interleukin-13 signaling. The drugs Fentanyl and Etomidate have been mentioned in the context of this disorder. Affiliated tissues include Lung, smooth muscle and skin, and related phenotypes are asthma and bronchoconstriction

9) Enterocolitis, Necrotizing
Perinatal Necrotizing Enterocolitis, also known as necrotizing enterocolitis, is related to enterocolitis and short bowel syndrome. An important gene associated with Perinatal Necrotizing Enterocolitis is HBEGF (Heparin Binding EGF Like Growth Factor), and among its related pathways/superpathways are ERK Signaling and Disease. The drugs Dexamethasone acetate and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include heart, neutrophil and breast, and related phenotypes are premature birth and hyponatremia

10) Kawasaki Disease
Kawasaki Disease, also known as mucocutaneous lymph node syndrome, is related to exanthem and conjunctivitis, and has symptoms including fever, congestion of ocular conjunctivae and reddening of lips. An important gene associated with Kawasaki Disease is THRIL (TNF And HNRNPL Related Immunoregulatory Long Non-Coding RNA), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Immunoglobulin G and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include body, lymph node and heart, and related phenotypes are proteinuria and cheilitis

11) Parkinson's Disease
Parkinson Disease, Late-Onset, also known as parkinson disease, is related to hereditary late-onset parkinson disease and parkinson disease 3, autosomal dominant, and has symptoms including angina pectoris, back pain and headache. An important gene associated with Parkinson Disease, Late-Onset is MAPT (Microtubule Associated Protein Tau), and among its related pathways/superpathways is Parkinson's disease pathway. The drugs Idebenone and Tadalafil have been mentioned in the context of this disorder. Affiliated tissues include Brain, and related phenotypes are hallucinations and abnormal autonomic nervous system physiology

12) Myocardial Infarction
Myocardial Infarction, also known as heart attack, is related to lipoprotein quantitative trait locus and cardiovascular system disease, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Myocardial Infarction is MIAT (Myocardial Infarction Associated Transcript), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway. The drugs Miconazole and Clotrimazole have been mentioned in the context of this disorder. Affiliated tissues include Bone and Limb.

13) Acute Coronary Syndrome
Ischemia, also known as acute coronary syndrome, is related to limb ischemia and lipoprotein quantitative trait locus, and has symptoms including anoxemia, polydipsia and muscle weakness. An important gene associated with Ischemia is LINC01254 (Long Intergenic Non-Protein Coding RNA 1254), and among its related pathways/superpathways are Signal Transduction and Response to elevated platelet cytosolic Ca2+. The drugs Lovastatin and Nadroparin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, heart and brain, and related phenotypes are homeostasis/metabolism and nervous system

14) Acute Lung Injury
Adult Respiratory Distress Syndrome, also known as acute respiratory distress syndrome, is related to critical covid-19 and pulmonary edema, and has symptoms including apnea, cheyne-stokes respiration and coughing. An important gene associated with Adult Respiratory Distress Syndrome is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Iron and Ibuprofen have been mentioned in the context of this disorder. Affiliated tissues include Lung, and related phenotypes are respiratory failure and tachypnea

15) Acute Kidney Injury
Acute Kidney Failure, also known as acute renal failure, is related to hemolytic-uremic syndrome and hemolytic uremic syndrome, atypical 1. An important gene associated with Acute Kidney Failure is MGAT3-AS1 (MGAT3 Antisense RNA 1), and among its related pathways/superpathways are Interleukin-4 and Interleukin-13 signaling and "Uricosurics Pathway, Pharmacodynamics". The drugs Desflurane and Racephedrine have been mentioned in the context of this disorder. Affiliated tissues include Bone and Adipose, and related phenotypes are homeostasis/metabolism and cardiovascular system

16) Pancreatitis, Chronic
Pancreatitis, Hereditary, also known as hereditary pancreatitis, is related to tropical calcific pancreatitis and prss1-related hereditary pancreatitis. An important gene associated with Pancreatitis, Hereditary is PRSS1 (Serine Protease 1), and among its related pathways/superpathways are MicroRNAs in cardiomyocyte hypertrophy and miRNAs involvement in the immune response in sepsis. The drugs Protein C and Etanercept have been mentioned in the context of this disorder. Affiliated tissues include pancreas, bone marrow and pancreatic islet, and related phenotypes are abdominal pain and leukocytosis

17) Palmoplantar Keratoderma
Palmoplantar Keratosis, also known as palmoplantar keratoderma, is related to keratoderma, palmoplantar, with deafness and palmoplantar keratoderma, nonepidermolytic, focal 1. An important gene associated with Palmoplantar Keratosis is CTSC (Cathepsin C), and among its related pathways/superpathways are Nervous system development and Cytoskeletal Signaling. The drugs Carbamide peroxide and Aspartic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, heart and tongue, and related phenotypes are no effect and no effect

18) Bronchiectasis
Bronchiectasis, also known as polynesian bronchiectasis, is related to bronchiectasis with or without elevated sweat chloride 1 and idiopathic bronchiectasis, and has symptoms including headache An important gene associated with Bronchiectasis is STAT1 (Signal Transducer And Activator Of Transcription 1), and among its related pathways/superpathways are Innate Immune System and Bacterial infections in CF airways. The drugs Tobramycin and Dimercaprol have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and neutrophil, and related phenotypes are no effect and no effect

19) Influenza
Influenza, also known as flu, is related to avian influenza and swine influenza, and has symptoms including chills, fever and sore throat. An important gene associated with Influenza is IVNS1ABP (Influenza Virus NS1A Binding Protein), and among its related pathways/superpathways are Innate Immune System and Disease. The drugs Hops and Coal tar have been mentioned in the context of this disorder. Affiliated tissues include heart, t cells and brain, and related phenotypes are no effect and no effect

20) Eczema
Dermatitis, also known as eczema, is related to irritant dermatitis and dermatitis herpetiformis, and has symptoms including exanthema and pruritus. An important gene associated with Dermatitis is FLG (Filaggrin), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Salicylic acid and Titanium dioxide have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and t cells, and related phenotypes are immune system and hematopoietic system

21) Anthrax
Anthrax Disease, also known as anthrax, is related to oropharyngeal anthrax and inhalation anthrax, and has symptoms including skin ulcer, nausea and poor appetite. An important gene associated with Anthrax Disease is ANTXR1 (ANTXR Cell Adhesion Molecule 1), and among its related pathways/superpathways are Disease and MIF Mediated Glucocorticoid Regulation. The drugs Promethazine and Histamine have been mentioned in the context of this disorder. Affiliated tissues include skin, lung lymph nodes and gastrointestinal tract, and related phenotypes are no effect and no effect

22) Pain
Paine Syndrome, also known as pain disorder, is related to paroxysmal extreme pain disorder and indifference to pain, congenital, autosomal recessive. An important gene associated with Paine Syndrome is HFE (Homeostatic Iron Regulator), and among its related pathways/superpathways are Cardiac conduction and Neuropathic Pain-Signaling in Dorsal Horn Neurons. The drugs Pregabalin and Dinoprostone have been mentioned in the context of this disorder. Affiliated tissues include dorsal root ganglion, spinal cord and breast, and related phenotypes are microcephaly and spastic diplegia

23) Cancer, Breast
Breast Cancer, also known as breast carcinoma, is related to ovarian cancer and hereditary breast ovarian cancer syndrome, and has symptoms including pelvic pain, lameness, animal and pain. An important gene associated with Breast Cancer is BRCA2 (BRCA2 DNA Repair Associated), and among its related pathways/superpathways are Gene expression (Transcription) and ERK Signaling. The drugs Prednisolone phosphate and Prednisolone acetate have been mentioned in the context of this disorder. Affiliated tissues include breast, lymph node and prostate, and related phenotypes are breast carcinoma and Decreased viability

24) Cancer, Prostate
Prostate Cancer, also known as prostate carcinoma, is related to breast cancer and prostate disease, and has symptoms including angina pectoris, tremor and equilibration disorder. An important gene associated with Prostate Cancer is CHEK2 (Checkpoint Kinase 2), and among its related pathways/superpathways are Endometrial cancer and Breast cancer pathway. The drugs Sodium citrate and Sildenafil have been mentioned in the context of this disorder. Affiliated tissues include prostate, bone and lymph node, and related phenotypes are prostate cancer and neoplasm

25) Dermatitis
Dermatitis, also known as eczema, is related to irritant dermatitis and dermatitis herpetiformis, and has symptoms including exanthema and pruritus. An important gene associated with Dermatitis is FLG (Filaggrin), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Salicylic acid and Titanium dioxide have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and t cells, and related phenotypes are immune system and hematopoietic system

26) Graft-versus-host Disease
Graft-Versus-Host Disease, also known as graft-versus-host disease, susceptibility to, is related to bronchiolitis obliterans and acute graft versus host disease. An important gene associated with Graft-Versus-Host Disease is IL10 (Interleukin 10), and among its related pathways/superpathways are Cytokine Signaling in Immune system and PAK Pathway. The drugs Tacrolimus and Lomustine have been mentioned in the context of this disorder. Affiliated tissues include Bone, bone marrow and t cells, and related phenotypes are elevated hepatic transaminase and skin erosion

27) Rheumatoid Arthritis
Rheumatoid Arthritis, also known as ra, is related to arthritis and psoriatic arthritis, and has symptoms including back pain, muscle cramp and sciatica. An important gene associated with Rheumatoid Arthritis is PTPN22 (Protein Tyrosine Phosphatase Non-Receptor Type 22), and among its related pathways/superpathways are NF-kappaB Signaling and Genes associated with the development of rheumatoid arthritis. The drugs Entecavir and Alendronic acid have been mentioned in the context of this disorder. Affiliated tissues include Cartilage, joint and bone, and related phenotypes are joint stiffness and fatigue

28) Diabetes
Diabetes Mellitus, also known as diabetes, is related to type 2 diabetes mellitus and gestational diabetes, and has symptoms including angina pectoris, tremor and equilibration disorder. An important gene associated with Diabetes Mellitus is KCNJ11 (Potassium Inwardly Rectifying Channel Subfamily J Member 11), and among its related pathways/superpathways are Regulation of beta-cell development and Cell differentiation - expanded index. The drugs Miconazole and Clotrimazole have been mentioned in the context of this disorder. Affiliated tissues include pancreas, bone marrow and kidney.

29) Rosacea
Rosacea, also known as erythematotelangiectatic rosacea, is related to telangiectasis and acne, and has symptoms including exanthema and pruritus. An important gene associated with Rosacea is CAMP (Cathelicidin Antimicrobial Peptide), and among its related pathways/superpathways are Innate Immune System and Disease. The drugs Metronidazole and Minocycline have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and pituitary, and related phenotypes are no effect and no effect

30) Tuberculosis
Mycobacterium Tuberculosis 1, also known as tuberculosis, is related to pulmonary tuberculosis and miliary tuberculosis, and has symptoms including coughing, fever and pruritus. An important gene associated with Mycobacterium Tuberculosis 1 is MTBS1 (Mycobacterium Tuberculosis, Susceptibility To Infection By, 1), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs Calcium carbonate and Etanercept have been mentioned in the context of this disorder. Affiliated tissues include lungs, lymph nodes and pericardium, and related phenotypes are fatigue and fever

31) Peeling Skin Syndrome, Acral Type
Peeling Skin Syndrome 2, also known as acral peeling skin syndrome, is related to peeling skin syndrome and ichthyosis. An important gene associated with Peeling Skin Syndrome 2 is TGM5 (Transglutaminase 5), and among its related pathways/superpathways is Keratinization. Affiliated tissues include skin, liver and pancreas, and related phenotypes are ichthyosis and high hypermetropia

32) Urticaria
Urticaria, also known as urticaria nos, is related to physical urticaria and chronic spontaneous urticaria, and has symptoms including abdominal pain, chest pain and constipation. An important gene associated with Urticaria is F12 (Coagulation Factor XII), and among its related pathways/superpathways are NF-kappaB Signaling and "Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics". The drugs Levoleucovorin and Dapsone have been mentioned in the context of this disorder. Affiliated tissues include upper dermis, skin and thyroid, and related phenotype is immune system.

33) Thrombosis
Complement Hyperactivation, Angiopathic Thrombosis, and Protein-Losing Enteropathy, also known as chaple, is related to blood group, cromer system and protein-losing enteropathy. An important gene associated with Complement Hyperactivation, Angiopathic Thrombosis, and Protein-Losing Enteropathy is CD55 (CD55 Molecule (Cromer Blood Group)). The drugs Dabigatran and Norethisterone have been mentioned in the context of this disorder. Affiliated tissues include liver, whole blood and endothelial, and related phenotypes are thrombocytosis and hepatomegaly

34) Angioedema, Hereditary
Angioedema, Hereditary, 1, also known as hereditary angioneurotic edema, is related to angioedema, hereditary, 3 and epiglottitis, and has symptoms including abdominal pain, diarrhea and vomiting. An important gene associated with Angioedema, Hereditary, 1 is SERPING1 (Serpin Family G Member 1), and among its related pathways/superpathways are Innate Immune System and Response to elevated platelet cytosolic Ca2+. The drugs Ciprofloxacin and Metronidazole have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and small intestine, and related phenotypes are muscle weakness and periorbital edema

35) Vasculitis
Vasculitis, also known as autoimmune vasculitis, is related to hypersensitivity vasculitis and churg-strauss syndrome, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Vasculitis is PRTN3 (Proteinase 3), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Innate Immune System. The drugs Cyclophosphamide and Alemtuzumab have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, lung and heart, and related phenotypes are immune system and hematopoietic system

36) Neuromyelitis Optica
Neuromyelitis Optica, also known as devic syndrome, is related to transverse myelitis and neuritis. An important gene associated with Neuromyelitis Optica is AQP4 (Aquaporin 4), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Antineoplastic Agents, Immunological and Daratumumab have been mentioned in the context of this disorder. Affiliated tissues include Umbilical Cord, spinal cord and eye, and related phenotypes are optic neuritis and visual loss

37) Psoriasis
Psoriasis is related to psoriasis 7 and psoriasis 10, and has symptoms including exanthema, pruritus and psoriasiform rash. An important gene associated with Psoriasis is MIR203A (MicroRNA 203a), and among its related pathways/superpathways are miRNAs involvement in the immune response in sepsis and Cell differentiation - expanded index. The drugs Metformin and Vedolizumab have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and endothelial.

38) Paroxysmal Nocturnal Hemoglobinuria
Paroxysmal Nocturnal Hemoglobinuria, also known as marchiafava-micheli disease, is related to hemolytic anemia and budd-chiari syndrome. An important gene associated with Paroxysmal Nocturnal Hemoglobinuria is PIGA (Phosphatidylinositol Glycan Anchor Biosynthesis Class A), and among its related pathways/superpathways are Innate Immune System and Response to elevated platelet cytosolic Ca2+. The drugs Warfarin and Sirolimus have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, spinal cord and bone, and related phenotypes are abnormal erythrocyte enzyme level and hemolytic anemia

39) Esophagitis, Eosinophilic

40) Hyperlipidemia
Familial Hyperlipidemia, also known as familial hyperlipoproteinemia, is related to hyperlipoproteinemia, type v and hyperlipoproteinemia, type i. An important gene associated with Familial Hyperlipidemia is APOB (Apolipoprotein B), and among its related pathways/superpathways are Metabolism and Transport of inorganic cations/anions and amino acids/oligopeptides. The drugs Evolocumab and Dapagliflozin have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and endothelial, and related phenotypes are no effect and no effect

41) Hyperglycemia
Hyperglycemia is related to type 1 diabetes mellitus and maturity-onset diabetes of the young, type 2, and has symptoms including cachexia, cyanosis and dyspnea. An important gene associated with Hyperglycemia is MALAT1 (Metastasis Associated Lung Adenocarcinoma Transcript 1), and among its related pathways/superpathways are Metabolism and Nervous system development. The drugs Saxagliptin and Aripiprazole have been mentioned in the context of this disorder. Affiliated tissues include endothelial, liver and brain, and related phenotypes are Decreased viability and Decreased viability

42) Ichthyosis
Ichthyosis, also known as ichthyoses, is related to ichthyosis, congenital, autosomal recessive 4b and autosomal recessive congenital ichthyosis, and has symptoms including trichorrhexis invaginata An important gene associated with Ichthyosis is TGM1 (Transglutaminase 1), and among its related pathways/superpathways are Keratinization and Prostaglandin 2 biosynthesis and metabolism FM. The drugs Ustekinumab and Emollients have been mentioned in the context of this disorder. Affiliated tissues include skin, neutrophil and lymph node, and related phenotypes are homeostasis/metabolism and growth/size/body region

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