CD14C: A Potential Drug Target and Biomarker (G168448)

CD14C: A Potential Drug Target and Biomarker

CD14C is a protein that is expressed in various tissues of the human body, including the lungs, heart, kidneys, and intestines. It is a key player in the immune system, where it helps to protect the body against pathogens and other harmful substances. Despite its critical functions, CD14C has also been identified as a potential drug target and biomarker. In this article, we will explore the biology and potential therapeutic applications of CD14C.

The Science Behind CD14C

CD14C is a type of transmembrane protein that is characterized by its extracellular domain, which is involved in cell-cell interactions and is known as the C-type transmembrane domain (TMD). The CD14C protein is composed of four structural domains: an N-terminal transmembrane domain, a TMD, a middle lumen domain, and an C-terminal cytoplasmic domain.

The N-terminal transmembrane domain is responsible for the protein's ability to interact with various cell surface molecules, including receptors and ion channels. The TMD is a structural domain that plays a key role in the protein's stability and functions. The middle lumen domain is responsible for the protein's ability to form inclusion complexes, which allow it to interact with other proteins in the cell. Finally, the C-terminal cytoplasmic domain is responsible for the protein's ability to localize to the endoplasmic reticulum (ER) and to be retained by endoplasmic reticulum-associated degradation (ERAD).

CD14C has been shown to play a critical role in various physiological processes, including immune responses, inflammation, and fibrosis. For example, CD14C is involved in the regulation of T cell responses, which are critical for immune defense against pathogens. Studies have shown that CD14C helps to ensure that T cells are able to recognize and respond to foreign antigens, which are essential for maintaining the body's immune against infections and other harmful substances.

In addition to its role in the immune system, CD14C has also been shown to be involved in various signaling pathways that are important for cell growth, apoptosis, and fibrosis. For example, studies have shown that CD14C can interact with the protein TIP30, which is involved in the regulation of cell growth and apoptosis. Additionally, CD14C has been shown to be involved in the regulation of the fibroblast growth and activation, which are critical for the development and progression of fibrosis.

Potential Therapeutic Applications

CD14C has been identified as a potential drug target due to its involvement in various signaling pathways that are important for both immune defense and fibrosis. One of the main goals of drug development is to identify compounds that can modulate the activity of CD14C and its downstream targets, in order to treat diseases that are characterized by inflammation, fibrosis, or immune dysfunction.

One potential therapeutic application of CD14C is the treatment of chronic obstructive pulmonary disease (COPD). COPD is a progressive lung disease that is characterized by airflow limitation and decreased lung function. The exact cause of COPD is not known, but it is thought to involve an imbalance between the actions of

Protein Name: Cell Division Cycle 14C

Functions: Dual-specificity phosphatase. Preferentially dephosphorylates proteins modified by proline-directed kinases (By similarity)

More Common Targets

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