PRIMPOL: A Potential Drug Target for DNA Replication and Transcription

Target Name: PRIMPOL

NCBI ID: G201973

PRIMPOL: A Potential Drug Target for DNA Replication and Transcription

PRIMPOL is a protein that plays a crucial role in the process of DNA replication and transcription. It is a key enzyme in the replication of DNA in eukaryotic cells, and is also involved in the transcription of DNA into RNA.PRIMPOL is a protein that is expressed in all eukaryotic cells and is involved in the process of DNA replication and transcription. It is a key enzyme in the replication of DNA in eukaryotic cells, and is also involved in the transcription of DNA into RNA.

One of the things that makes PRIMPOL an interesting potential drug target is its role in the process of DNA replication. PRIMPOL is involved in the production of new DNA strands that are replicated in the cell after the original DNA template has been damaged or deleted. This process is essential for the survival of the cell, as it allows the cell to repair any DNA damage and continue to function.

Another potential drug target for PRIMPOL is its role in the transcription of DNA into RNA. PRIMPOL is involved in the production of RNA from DNA, which is the first step in the process of gene expression. This means that any changes made to the DNA template will be reflected in the RNA produced. This makes PRIMPOL an attractive target for drugs that are designed to prevent or reverse changes to the DNA template.

In addition to its role in DNA replication and transcription, PRIMPOL is also involved in the regulation of gene expression. It does this by interacting with other proteins, including RNA polymerase II (RNA-II), which is a key enzyme in the transcription of DNA into RNA. This interaction between PRIMPOL and RNA-II allows PRIMPOL to regulate the speed at which RNA is produced from the DNA template.

The use of PRIMPOL as a drug target is still in the early stages of research, but it has the potential to be a valuable tool for the treatment of a variety of diseases. For example, PRIMPOL has been shown to be involved in the development of certain types of cancer, and may be a useful target for these diseases. Additionally, PRIMPOL has also been shown to be involved in the development of genetic disorders, and may be a useful target for these conditions as well.

Overall, PRIMPOL is a protein that plays a crucial role in the process of DNA replication and transcription. Its involvement in these processes makes it an attractive target for drugs that are designed to prevent or reverse changes to the DNA template. As research continues to develop, it will be interesting to see how PRIMPOL can be used to treat a variety of diseases.

Protein Name: Primase And DNA Directed Polymerase

Functions: DNA primase and DNA polymerase required to tolerate replication-stalling lesions by bypassing them (PubMed:24126761, PubMed:24207056, PubMed:24240614, PubMed:24267451, PubMed:25255211, PubMed:24682820, PubMed:25262353, PubMed:25746449, PubMed:25550423, PubMed:27989484, PubMed:29608762, PubMed:30889508, PubMed:28534480). Required to facilitate mitochondrial and nuclear replication fork progression by initiating de novo DNA synthesis using dNTPs and acting as an error-prone DNA polymerase able to bypass certain DNA lesions (PubMed:24126761, PubMed:24207056, PubMed:24240614, PubMed:24267451, PubMed:25255211, PubMed:24682820, PubMed:25262353, PubMed:25746449, PubMed:25550423, PubMed:27989484, PubMed:29608762, PubMed:30889508, PubMed:30633872, PubMed:28534480). Shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA (PubMed:24126761, PubMed:24207056, PubMed:24240614, PubMed:24267451, PubMed:25746449). Provides different translesion synthesis alternatives when DNA replication is stalled: able to synthesize DNA primers downstream of lesions, such as ultraviolet (UV) lesions, R-loops and G-quadruplexes, to allow DNA replication to continue (PubMed:24240614, PubMed:26626482, PubMed:28534480, PubMed:30478192). Can also realign primers ahead of 'unreadable lesions' such as abasic sites and 6-4 photoproduct (6-4 pyrimidine-pyrimidinone), thereby skipping the lesion (PubMed:25746449). Also able to incorporate nucleotides opposite DNA lesions such as 8oxoG, like a regular translesion synthesis DNA polymerase (PubMed:24207056, PubMed:25255211, PubMed:25746449). Also required for reinitiating stalled forks after UV damage during nuclear DNA replication (PubMed:24240614). Required for mitochondrial DNA (mtDNA) synthesis and replication, by reinitiating synthesis after UV damage or in the presence of chain-terminating nucleotides (PubMed:24207056). Prevents APOBEC family-mediated DNA mutagenesis by repriming downstream of abasic site to prohibit error-prone translesion synthesis (By similarity). Has non-overlapping function with POLH (PubMed:24240614). In addition to its role in DNA damage response, also required to maintain efficient nuclear and mitochondrial DNA replication in unperturbed cells (PubMed:30715459)

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