PRKCZ: A Key Regulator of Cell Signaling Pathways (G5590)

Target Name: PRKCZ

NCBI ID: G5590

PRKCZ: A Key Regulator of Cell Signaling Pathways

PRKCZ (nPKC-zeta), also known as PKC-zeta, is a protein that is expressed in various tissues and cells throughout the body. It is a key regulator of cell signaling pathways, including the G-protein-coupled receptor (GPCR) signaling pathway. PRKCZ has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and psychiatric disorders.

The GPCR signaling pathway is a critical pathway that involves the interaction between intracellular signaling molecules and GPCRs, which are found on the surface of many cell types. The pathway is involved in a wide range of physiological processes, including sensory perception, neurotransmission, and hormone signaling. PRKCZ is a key regulator of this pathway, and its function is to regulate the activity of GPCRs.

Studies have shown that PRKCZ plays a critical role in the regulation of GPCR signaling in various tissues and cells. For example, researchers have found that PRKCZ is highly expressed in the brain and that it is involved in the regulation of GPCR signaling in this tissue. They have also shown that PRKCZ is involved in the regulation of sensory perception in the eye, and that it plays a role in the regulation of neurotransmission in the brain.

In addition to its role in GPCR signaling, PRKCZ has also been shown to be involved in the regulation of other signaling pathways, including the T-cell receptor (TCR) signaling pathway and the mitochondrial signaling pathway. The TCR signaling pathway is involved in the regulation of cell growth, differentiation, and survival, and is involved in the development and regulation of many diseases, including cancer. The mitochondrial signaling pathway is involved in the regulation of energy metabolism and is involved in the development and progression of many diseases, including neurodegenerative diseases.

PRKCZ has also been shown to be involved in the regulation of cellular processes that are important for maintaining tissue homeostasis. For example, studies have shown that PRKCZ is involved in the regulation of cell migration and that it plays a role in the development of cancer. PRKCZ has also been shown to be involved in the regulation of the cytoskeleton, which is responsible for the structure and mechanical properties of cells.

In conclusion, PRKCZ is a protein that is involved in the regulation of a wide range of cellular processes that are important for maintaining tissue homeostasis and for the development and regulation of many diseases. As a potential drug target and biomarker, PRKCZ has the potential to be a valuable tool for the development of new therapies for a wide range of diseases. Further research is needed to fully understand the role of PRKCZ in cellular signaling pathways and to develop effective treatments based on this protein.

Protein Name: Protein Kinase C Zeta

Functions: Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311'. Phosphorylates VAMP2 in vitro (PubMed:17313651)

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