PCDH: Key Regulator of Cell-Cell Adhesion and Drug Target (P48237)

Target Name: Protocadherin

NCBI ID: P48237

Other Name(s): PCDH

PCDH: Key Regulator of Cell-Cell Adhesion and Drug Target

Protocadherin (PCDH) is a transmembrane protein that plays a crucial role in cell-cell adhesion. It is a member of the cadherin family, which includes cadherins, n cadherins, and p cadherins, and is responsible for ensuring the proper assembly and maintenance of cell-cell adhesion.

PCDH is a non-specified subtype of cadherin protein, which means that it falls between the specific cadherins and n cadherins. This subtype is characterized by the presence of a unique C-terminus that is unique to Protocadherin.

One of the key functions of PCDH is its role in cell-cell adhesion. It helps to regulate the assembly and disassembly of cadherin proteins, which are essential for the formation of tight junctions and the maintenance of tissue boundaries.

PCDH is also involved in several other cellular processes, including cell signaling, cell division, and the regulation of cell growth. It is a key regulator of the Wnt signaling pathway, which is responsible for the development and maintenance of tissues and organs.

PCDH is also a potential drug target and biomarker. Researchers are currently working to develop drugs that can target PCDH to treat a variety of diseases, including cancer, neurodegenerative diseases, and developmental disorders.

One approach to targeting PCDH is to use small molecules that can modulate its activity. These molecules can be designed to interact with specific PCDH domains, such as the C-terminus, and can either activate or inhibit its activity.

Another approach to targeting PCDH is to use antibodies that can specifically recognize and target its C-terminus. This approach has been used to treat a variety of diseases, including cancer and neurodegenerative disorders.

Overall, PCDH is a complex and important protein that plays a crucial role in cell-cell adhesion and several other cellular processes. Its unique subtype and unique C-terminus make it an attractive target for drug development and research.

Protein Name: Protocadherin (nonspecified Subtype)

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