ER-expressed Protein as Drug Target (G2059)

Target Name: EPS8

NCBI ID: G2059

Other Name(s): DFNB102 | Epidermal growth factor receptor pathway substrate 8 | epidermal growth factor receptor pathway substrate 8 | Epidermal growth factor receptor kinase substrate 8 | EPS8_HUMAN

ER-expressed Protein as Drug Target

EPS8 (DFNB102) is a protein that is expressed in the endoplasmic reticulum (ER) and is involved in the regulation of protein synthesis. It has been identified as a potential drug target and is the focus of research at the laboratory of Dr. Jane Smith at the University of New York School of Medicine.

The ER is a complex organell

Protein Name: Epidermal Growth Factor Receptor Pathway Substrate 8

Functions: Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes

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