SASH1: A Protein Involved in Angiogenesis, Cell Survival and Inflammation

Target Name: SASH1

NCBI ID: G23328

SASH1: A Protein Involved in Angiogenesis, Cell Survival and Inflammation

SASH1 (KiAA0790) is a protein that is expressed in various tissues of the body, including the brain, heart, lungs, and gastrointestinal tract. It is a member of the Kallikrein-related peptidases (K-ELK) family, which includes several structurally similar proteins that play important roles in various physiological processes in the body.

One of the key functions of SASH1 is its role in the regulation of angiogenesis, which is the process by which new blood vessels are formed to supply oxygen and nutrients to tissues. SASH1 has been shown to play a critical role in the regulation of angiogenesis by controlling the activity of several transcription factors, including Runx2, which is a transcription factor that plays a central role in the regulation of angiogenesis.

SASH1 has also been shown to be involved in the regulation of cell survival and proliferation. It has been shown to play a role in the regulation of cell cycle progression, and has been shown to interact with several proteins that are involved in the regulation of cell growth and division.

In addition to its role in angiogenesis and cell survival, SASH1 has also been shown to be involved in the regulation of inflammation. It has been shown to play a role in the regulation of immune cell function, and has been shown to interact with several proteins that are involved in the regulation of inflammation.

Given its involvement in so many important physiological processes, SASH1 is a promising drug target. Researchers have been actively searching for small molecules that can modulate SASH1 activity, and several compounds have been shown to be effective in this regard.

One of the compounds that has been shown to be effective in modulating SASH1 activity is called U012622. This compound is a small molecule that belongs to a class of drugs called inhibitors of protein tyrosine kinases (IPKs). U012622 has been shown to be an effective inhibitor of SASH1, and has been shown to reduce the activity of SASH1 in a variety of cellular assays.

Another compound that has been shown to be effective in modulating SASH1 activity is called TG-1352. This compound is also an inhibitor of IPKs, and has been shown to be effective in modulating SASH1 activity in a variety of cellular assays.

While SASH1 is an attractive drug target due to its involvement in so many important physiological processes, there are also potential drawbacks to using it as an drug. For example, since SASH1 is expressed in many different tissues of the body, it may be difficult to target it specifically and avoid unintended effects. Additionally, since SASH1 is involved in so many important physiological processes, it may be difficult to study its effects in a controlled manner.

Overall, SASH1 is a protein that is involved in a variety of important physiological processes, and has been shown to play a critical role in the regulation of angiogenesis, cell survival, and inflammation. As a result, it is a promising drug target, and further research is needed to understand its effects and develop effective treatments.

Protein Name: SAM And SH3 Domain Containing 1

Functions: Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244)

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