FOLR2: A Potential Drug Target for Neurological Disorders (G2350)

Target Name: FOLR2

NCBI ID: G2350

FOLR2: A Potential Drug Target for Neurological Disorders

The folate receptor, beta (FOLR2) is a protein that is expressed in various tissues throughout the body, including the brain, spinal cord, and peripheral nerves. It is a member of the TGF-beta receptor family and is involved in the regulation of cell growth, differentiation, and survival.

FOLR2 has been identified as a potential drug target and is currently being investigated as a potential therapeutic approach for a variety of neurological and psychiatric disorders.

One of the key functions of FOLR2 is its role in the regulation of cell proliferation. FOLR2 has been shown to play a positive role in the growth and development of neurons, and is required for the proper formation of the myelin sheath surrounding neurons.

FOLR2 is also involved in the regulation of cell differentiation and plasticity. It has been shown to be involved in the switch between stem cell and progenitor cell, and is required for the development and maintenance of neural stem cells.

In addition to its role in cell biology, FOLR2 is also thought to be involved in the regulation of immune responses and inflammation. It has been shown to be involved in the regulation of T cell development and function, and is required for the production of antibodies in response to infection.

FOLR2 is also a potential biomarker for several neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. It has been shown to be expressed in the brains of individuals with these disorders, and may be a useful diagnostic or therapeutic target for these conditions.

In conclusion, FOLR2 is a protein that plays a critical role in the regulation of cell growth, differentiation, and survival. It is a potential drug target and may be a useful therapeutic approach for the treatment of neurological and psychiatric disorders. Further research is needed to fully understand the role of FOLR2 in these processes and to develop effective treatments.

Protein Name: Folate Receptor Beta

Functions: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release

More Common Targets