RNAU1-18: A Versatile RNA-protein Complex Involved in Various Cellular Processes

Target Name: RNVU1-18

NCBI ID: G26863

Other Name(s): RNU1P1 | U1.15 | RNA, variant U1 small nuclear 18 | RNU1-25 | U1P15 | RNU1-5 | vU1.18 | RNU1-25P | U1P101 | RNU1P9

RNAU1-18: A Versatile RNA-protein Complex Involved in Various Cellular Processes

The RNA-protein complex (RNA-protein) is a ubiquitous entity in all cells, and it plays a crucial role in various cellular processes. One of the well-known RNA-protein complexes is the nucleolin binding partner RNAU (RNU) family, which consists of different subfamilies, including RNU1-18 (RNU1P1). RNU1-18 is a protein that was first identified in the nucleoplasm using Southern blotting techniques, and it has been shown to interact with various RNA molecules, including rRNA, snRNA , and microRNA (miRNA) species.

RNAU1-18 is a 21-kDa protein that contains 108 amino acid residues. It has a characteristic imidazole ring structure and is composed of two distinct domains: an N-terminal domain and a C-terminal domain. The N-terminal domain is rich in conserved features, such as a leucine amino acid residue, a glutamic acid amino acid residue, and a lysine amino acid residue, which are all involved in protein-protein interactions. The C-terminal domain is also conserved and is involved in the formation of a hydrogen bond with the N-terminal domain.

RNAU1-18 has been shown to play a critical role in various cellular processes, including cell growth, apoptosis, and translation. One of the well-known functions of RNU1-18 is its ability to interact with small RNA species, such as miRNA and rRNA. miRNA, a small non-coding RNA molecule, plays a crucial role in post-transcriptional regulation by targeting mRNAs for degradation. RNU1-18 has been shown to interact with miRNA species, including miR-18a, miR-202, and miR -21, and it has been shown to regulate the translation of miRNA precursors into functional miRNAs.

In addition to its role in miRNA regulation, RNU1-18 has also been shown to play a critical role in the regulation of alternative splicing. Alternative splicing is a process by which the cell removes non-coding exons from the pre-mRNA and uses the remaining exons to generate a functional RNA product. RNU1-18 has been shown to interact with the protein ExonicOrder (XO), which is a component of the splicing machinery. By interacting with XO, RNU1-18 has been shown to regulate the exonic inclusion of exons in the final RNA product.

RNAU1-18 has also been shown to play a critical role in the regulation of cell growth and apoptosis. The growth and apoptosis of cells are highly regulated processes that are tightly controlled by various signaling pathways. RNU1-18 has been shown to interact with several signaling pathways, including the TGF-β pathway and the PI3K/Akt pathway.

TGF-β is a well-known signaling pathway that regulates cell growth and apoptosis. TGF-β signaling is dependent on the interaction between the TGF-β receptor and the Smad protein. RNU1-18 has been shown to interact with the TGF-β receptor and has been shown to regulate the translation of TGF-β signaling proteins into the cell.

The PI3K/Akt signaling pathway is another well-known signaling pathway that regulates cell growth and apoptosis. PI3K is a protein that plays a critical role in the regulation of cell membrane rigidity and is involved in the production of pro-inflammatory cytokines. Akt is a protein that is involved in the regulation of cell growth and apoptosis by phosphate

Protein Name: RNA, Variant U1 Small Nuclear 18

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