CYP51A1P3: A Drug Target / Disease Biomarker (G100422264)

Target Name: CYP51A1P3

NCBI ID: G100422264

Other Name(s): Cytochrome P450 family 51 subfamily A member 1 pseudogene 3 | cytochrome P450 family 51 subfamily A member 1 pseudogene 3 | CYP51P3

CYP51A1P3: A Drug Target / Disease Biomarker

CYP51A1P3 is a gene that encodes a protein known as CYP51A1P3. This protein is a key regulator of the cytochrome P450 (CYP) enzyme family, which is responsible for metabolizing a wide variety of drugs and other molecules. CYP51A1P3 is a splice variant gene that is located on chromosome 19 at position 3.

The CYP51A1P3 protein is a 19 kDa protein that is expressed in most tissues and cells in the body. It is primarily localized to the cytoplasm of cells, but can also be found in the endoplasmic reticulum (ER) and the nuclear envelope (NE). The CYP51A1P3 protein is known to play a role in the regulation of cellular processes such as cell growth, apoptosis (programmed cell death), and inflammation.

One of the key functions of the CYP51A1P3 protein is its role in the regulation of CYP enzyme activity. The CYP51A1P3 protein is a negative regulator of the CYP450 enzyme, which is responsible for metabolizing a wide variety of drugs and other molecules. The CYP51A1P3 protein helps to regulate the activity of the CYP450 enzyme by interacting with its active site, which is the site on the enzyme where the substrate binds.

The CYP51A1P3 protein is also involved in the regulation of cellular apoptosis. Apoptosis is a critical mechanism that helps cells to remove damaged or unnecessary proteins, and it is guided by a set of intracellular signals. The CYP51A1P3 protein is known to play a role in the regulation of apoptosis by interacting with the Bcl-2 protein, which is a protein that is involved in the regulation of apoptosis.

In addition to its role in regulating CYP enzyme activity and apoptosis, the CYP51A1P3 protein is also involved in the regulation of cellular inflammation. The CYP51A1P3 protein is known to play a role in the regulation of the production of pro-inflammatory cytokines, such as interleukin-1 (IL-1).

The CYP51A1P3 gene has been implicated in a number of diseases, including cardiovascular disease, neurodegenerative diseases, and autoimmune diseases. For example, studies have suggested that individuals with certain genetic variations in the CYP51A1P3 gene may be at increased risk of developing cardiovascular disease, such as heart failure and sudden cardiac death.

In conclusion, the CYP51A1P3 protein is a key regulator of the cytochrome P450 enzyme family and is involved in a wide range of cellular processes, including cell growth, apoptosis, and inflammation. Its role in these processes makes it an attractive target for drug development and research into the regulation of cellular processes. Further research is needed to fully understand the functions of the CYP51A1P3 protein and its potential as a drug target.

Protein Name: Cytochrome P450 Family 51 Subfamily A Member 1 Pseudogene 3

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