IGHV1-14: A Master Regulator of Immune Response and Cell Survival

Target Name: IGHV1-14

NCBI ID: G28470

Other Name(s): IGHV114 | immunoglobulin heavy variable 1-14 (pseudogene) | Immunoglobulin heavy variable 1-14 (pseudogene) | 1-14P

IGHV1-14: A Master Regulator of Immune Response and Cell Survival

IGHV1-14 (IGHV114) is a human interleukin-gene (IL-gene) that is expressed in various tissues and cells throughout the body.IL-gene family plays a crucial role in the regulation of immune responses, and IGHV1-14 is one of the most well-studied genes in this family.

IGHV1-14 is a 14-kDa transmembrane protein that is expressed in various tissues and cells throughout the body, including the spleen, thymus, lung, heart, and brain. It is a member of the IL-gene family, which includes several other genes that are involved in the regulation of immune responses.

IGHV1-14 is involved in the development and regulation of T cells, B cells, and natural killer cells. It is a key regulator of the T cell receptor (TCR), which is responsible for the recognition of foreign antigens by T cells. IGHV1-14 plays a crucial role in the development and regulation of T cells by promoting the expansion and differentiation of T cell progenitors, and by regulating the expression of genes that are involved in T cell receptor function.

IGHV1-14 is also involved in the regulation of B cell development and function. It is a key regulator of the B cell receptor (BCR), which is responsible for the recognition of foreign antigens by B cells. IGHV1-14 plays a crucial role in the development and regulation of B cells by promoting the expansion and differentiation of B cell progenitors, and by regulating the expression of genes that are involved in B cell receptor function.

IGHV1-14 is also involved in the regulation of natural killer cell development and function. It is a key regulator of the natural killer cell receptor (NKCR), which is responsible for the recognition of foreign antigens by natural killer cells. IGHV1-14 plays a crucial role in the development and regulation of natural killer cells by promoting the expansion and differentiation of natural killer cell progenitors, and by regulating the expression of genes that are involved in NKCR function.

In addition to its role in the regulation of immune cells, IGHV1-14 is also involved in the regulation of inflammation and immune tolerance. It is a key regulator of the cytokine signaling pathway, which is responsible for the regulation of inflammation and immune tolerance. IGHV1-14 plays a crucial role in the regulation of cytokine signaling by promoting the production and regulation of cytokines, and by regulating the expression of genes that are involved in cytokine signaling.

IGHV1-14 is also involved in the regulation of cell survival and death. It is a key regulator of the p53 signaling pathway, which is responsible for the regulation of cell survival and death. IGHV1-14 plays a crucial role in the regulation of p53 signaling by promoting the production and regulation of p53-controlled genes, and by regulating the expression of genes that are involved in p53 signaling.

In conclusion, IGHV1-14 is a well-studied gene that is involved in the regulation of immune responses, inflammation, and cell survival and death. Its functions as a drug target or biomarker make it an attractive target for further research and development. Further studies are needed to fully understand the role of IGHV1-14 in the regulation of immune responses and to develop new treatments for immune-related diseases.

Protein Name: Immunoglobulin Heavy Variable 1-14 (pseudogene)

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