TRBV6-3: A Potential Drug Target and Biomarker (G28604)

Target Name: TRBV6-3

NCBI ID: G28604

Other Name(s): TRBV63 | TCRBV13S9/13S2A1T | TCRBV6S3 | T cell receptor beta variable 6-3

TRBV6-3: A Potential Drug Target and Biomarker

TRBV6-3, also known as transforming growth factor-beta 6 (TGF-β6), is a protein that plays a crucial role in cell growth, differentiation, and repair. It is a key regulator of the TGF-β signaling pathway, which is a well-established regulator of cellular processes such as cell growth, angiogenesis, and tissue repair. TRBV6-3 has been identified as a potential drug target and biomarker for several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

The TGF-β signaling pathway is a complex network of proteins that work together to regulate cellular processes. The pathway is composed of four main components: TGF-β1, TGF-β2, TGF-β3, and TGF-β5. TGF-β1 and TGF-β2 are cytoplasmic proteins that promote cell growth and differentiate by regulating cell proliferation and cell-cell adhesion. TGF-β3 and TGF-β5 are membrane-bound proteins that promote cell-extracellular matrix (ECM) interactions and play a role in tissue repair and regeneration.

TRBV6-3 is a 21-kDa protein that is expressed in various tissues and cells, including muscle, nerve, heart, and liver cells. It is a key regulator of the TGF-β6 signaling pathway and has been shown to play a role in several cellular processes, including cell growth, differentiation, and repair.

TRBV6-3 has been shown to promote cell growth and proliferation by regulating the activity of the TGF-β signaling pathway. It does this by interacting with several transcription factors, including Myrbp1, which is a key regulator of TGF-β signaling. Myrbp1 is a nuclear protein that is expressed in various tissues and cells and has been shown to play a role in regulating cellular processes such as cell growth, apoptosis, and transcriptional regulation.

TRBV6-3 has also been shown to promote the formation of tissues and organs during development and repair. For example, during embryonic development, TRBV6-3 is involved in the formation of heart tissue and in the regulation of cardiac function. In adult tissue repair, TRBV6-3 has been shown to promote the formation of new tissues, such as muscle tissue, during the process of wound healing.

TRBV6-3 has also been shown to be involved in the regulation of pain perception and neurodegenerative diseases. For example, TRBV6-3 has been shown to contribute to the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, by regulating the activity of TGF-β signaling pathway. It has also been shown to be involved in the regulation of pain perception, by interacting with the neurotransmitter GABA.

In conclusion, TRBV6-3 is a protein that plays a crucial role in cell growth, differentiation, and repair. It is a key regulator of the TGF-β signaling pathway and has been shown to contribute to the development and progression of several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. As a potential drug target and biomarker, TRBV6-3 is a promising target for the development of new therapies for these diseases. Further research is needed to fully understand the role of TRBV6-3 in cellular processes and its potential as a drug target.

Protein Name: T Cell Receptor Beta Variable 6-3

Functions: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)

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