TRIM31: Unlocking The Potential of A TRIM Family Protein (G11074)

Target Name: TRIM31

NCBI ID: G11074

TRIM31: Unlocking The Potential of A TRIM Family Protein

TRIM31 (TRI31_HUMAN) is a protein that is expressed in various tissues of the human body, including the brain, heart, liver, and kidneys. It is a member of the TRIM family of proteins, which are involved in the regulation of DNA replication and repair.

TRIM31 is unique because of its ability to interact with DNA double-strands, which allows it to play a role in the regulation of gene expression and DNA replication. This interaction between TRIM31 and DNA has led to its potential as a drug target or biomarker.

One of the key challenges in studying TRIM31 is its complex structure. Unlike many other proteins, TRIM31 is not a single chain, but rather a trimeric protein composed of three subunits. This complexity can make it difficult to study the protein's interactions with DNA and other molecules.

However, researchers have been able to use a variety of techniques to study TRIM31's behavior. One of the most common methods is biochemical assays, such as protein-protein interactions (PPI) assays. These assays can detect the presence of specific interactions between TRIM31 and other proteins or nucleic acids, such as DNA.

Another approach used to study TRIM31 is mass spectrometry (MS). This technique allows researchers to identify and quantify the different subunits of TRIM31, as well as to study the structure-activity relationships between these subunits.

In addition to these studies, researchers have also used computational tools to study TRIM31's structure and function. These tools include molecular dynamics simulations, which allow researchers to model the movement of TRIM31 subunits and study their interactions with DNA, as well as bioinformatics tools, such as homology modeling and molecular docking, which can predict the structure and activity of new TRIM31 variants.

Despite these efforts, much of the biology of TRIM31 remains un understood. For example, while TRIM31 has been shown to play a role in the regulation of gene expression, it is not clear exactly how this regulation occurs or what the full range of effects of TRIM31's activity is.

In addition, there is a need for more research on the safety and effectiveness of TRIM31 as a drug target or biomarker. While TRIM31 has shown promise in preclinical studies, further studies are needed to determine its safety and effectiveness in humans.

In conclusion, TRIM31 is a protein that is expressed in various tissues of the human body and has the potential to be a drug target or biomarker. Its complex structure and the challenges associated with studying it make it difficult to fully understand its biology, but these challenges are being addressed by ongoing research. Further research is needed to determine TRIM31's safety and effectiveness as a potential drug target or biomarker.

Protein Name: Tripartite Motif Containing 31

Functions: E3 ubiquitin-protein ligase that acts as a regulator of antiviral immune response and inflammation by mediating ubiquitination of substrates (PubMed:18773414, PubMed:27929086, PubMed:27992402). Acts as a regulator of innate immune defense against viruses by mediating 'Lys-63'-linked ubiquitination of MAVS, promoting MAVS polymerization and formation of three-stranded helical filaments on mitochondria (PubMed:27992402). Acts as a negative regulator of the NLRP3 inflammasome by catalyzing 'Lys-48'-linked ubiquitination of NLRP3, leading to its degradation (PubMed:27929086). Regulator of Src-induced anchorage independent cell growth (By similarity)

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