TRMT44: A Protein Linked To Genetic Disorders and Cancer (G152992)

Target Name: TRMT44

NCBI ID: G152992

TRMT44: A Protein Linked To Genetic Disorders and Cancer

TRMT44 (Transcript Methyltransferase 44 Homolog) is a gene that encodes a protein known as TRMT44, which is involved in the transfer of methyl groups to specific DNA loci. Mutations in the TRMT44 gene have been linked to a variety of genetic disorders, including leukemia, and have also been identified as potential drug targets.

The TRMT44 protein is a key player in the epigenetic regulation of gene expression, as it plays a critical role in the transfer of methyl groups to specific DNA loci. Methylation of DNA is a highly conserved method of gene regulation that has the potential to alter gene expression and contribute to the development of a variety of diseases.

TRMT44 is a 21-kDa protein that consists of 115 amino acid residues. It belongs to the group of DNA methyltransferases, which are a class of proteins that use methyl groups as a tag for the transfer of genetic information from one generation to the next. These proteins are highly conserved and are found in all eukaryotic organisms, including humans.

TRMT44 is expressed in a variety of tissues and cells, including fetal brain, liver, and muscle, and has been shown to be involved in the regulation of gene expression in these tissues. For example, studies have shown that TRMT44 is highly expressed in fetal brain and is involved in the regulation of neuronal gene expression.

In addition to its role in gene expression, TRMT44 is also known for its potential as a drug target. Studies have shown that TRMT44 is a potential target for small molecule inhibitors, such as inhibitors of DNA methylation complexes. These inhibitors have been shown to be effective in treating a variety of diseases, including cancer, and may be a promising new approach to treating these diseases.

Another potential application of TRMT44 as a drug target is its role in the regulation of cellular processes that are important for cancer development. For example, studies have shown that TRMT44 is involved in the regulation of cell cycle progression and that it is a potential target for inhibitors of cell cycle progression.

In conclusion, TRMT44 is a protein that is involved in the regulation of gene expression and has been linked to a variety of genetic disorders. It is also a potential drug target due to its role in the regulation of cellular processes that are important for cancer development . Further research is needed to fully understand the role of TRMT44 in these processes and to develop effective treatments for the diseases that are associated with its mutations.

Protein Name: TRNA Methyltransferase 44 Homolog

Functions: Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase

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