COMMD5 Regulates T Cell Development and Function (G28991)

Target Name: COMMD5

NCBI ID: G28991

COMMD5 Regulates T Cell Development and Function

COMMD5 (HT002) is a protein that is expressed in various tissues throughout the body, including the brain, heart, liver, and kidneys. It is a member of theCOMMD5 family, which includes several other proteins that are involved in the regulation of cellular processes such as inflammation, DNA replication, and cell adhesion.

COMMD5 is known for its role in the regulation of the immune response, specifically in the regulation of T cell development and function. T cells are a crucial part of the immune system, and they play a key role in protecting the body against infection and disease. The regulation of T cell development and function is critical for maintaining the immune system's ability to effectively respond to threats.

COMMD5 is involved in the development and function of T cells by regulating the production of T cells from stem cells. T cells are derived from stem cells, which are special cells that have the ability to develop into any type of cell in the body. When stem cells differentiate into T cells, they require the production of a specific type of cell surface receptor, known as the T cell receptor (TCR).

COMMD5 is involved in the regulation of T cell receptor (TCR) production by interacting with a protein called nuclear factor of T cells (NFAT). NFAT is a transcription factor that plays a key role in the regulation of T cell development and function. When NFAT is activated, it causes the production of TCR, which is the protein that T cells use to recognize and respond to specific antigens.

COMMD5 is also involved in the regulation of T cell receptor (TCR) function by interacting with another protein calledPD-L1. PD-L1 is a protein that is expressed in many different types of cells, including T cells. It is involved in the regulation of T cell function by allowing T cells to evade immune surveillance and survive in the body for an extended period of time.

COMMD5 is a potential drug target for several reasons. Firstly, it is involved in the regulation of T cell development and function, which is critical for maintaining the immune system's ability to effectively respond to threats. Secondly, it is a protein that is expressed in various tissues throughout the body, which makes it an attractive target for drug development. Finally, its structure and function have been studied extensively, which provides a good foundation for the development of new drugs.

COMMD5 has been shown to play a key role in the regulation of T cell development and function. Studies have shown that whenCOMMD5 is expressed in T cells, it can cause T cells to develop and differentiate into functional T cells that are able to recognize and respond to specific antigens. Additionally, studies have shown that whenCOMMD5 is inhibited, T cells are unable to develop and differentiate into functional T cells.

COMMD5 has also been shown to be involved in the regulation of T cell receptor (TCR) function. Studies have shown that whenCOMMD5 is expressed in T cells, it can cause T cells to produce TCR, which are the proteins that T cells use to recognize and respond to specific antigens. Additionally, studies have shown that whenCOMMD5 is inhibited, T cells are unable to produce TCR, which leads to a reduction in the ability of T cells to recognize and respond to specific antigens.

COMMD5 is a protein that is involved in the regulation of T cell development and function, and it has been shown to play a key role in this process. As a result, it is a potential drug target for the development of new treatments for a variety of diseases.

In conclusion, COMMD5 (HT002) is a protein that is expressed in various tissues throughout the body, including the brain, heart, liver, and kidneys. It is a member of theCOMMD5 family, which includes several other proteins that are involved in the regulation of cellular processes such as inflammation, DNA replication, and

Protein Name: COMM Domain Containing 5

Functions: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B (PubMed:15799966)

More Common Targets