ADGRE4P: A GPCR Receptor for Pain and Stress (G326342)

Target Name: ADGRE4P

NCBI ID: G326342

ADGRE4P: A GPCR Receptor for Pain and Stress

ADGRE4P (ADGRE4-positive G protein-coupled receptor 4) is a protein that is expressed in various tissues and cells in the body. It is a member of the G protein-coupled receptor (GPCR) family, which is a large superfamily of transmembrane proteins that play a critical role in cellular signaling.

ADGRE4P is a 12-kDa protein that is expressed in the brain, heart, kidneys, and liver. It is primarily localized to the perceptual system, which is responsible for the sense of touch and body position. It is also expressed in the endothelial system, which is responsible for maintaining blood pressure and blood flow.

ADGRE4P is involved in a wide range of physiological processes in the body, including sensory perception, cardiovascular function, and blood pressure regulation. It is involved in the development and maintenance of neural circuits in the brain, and it is thought to play a role in the regulation of pain and stress.

ADGRE4P is also a potential drug target, and it is the focus of research at the laboratory of Dr. Xinran Li at the University of California, San Diego. Dr. Li and his team are studying the role of ADGRE4P in pain perception and the development of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

One of the challenges in studying ADGRE4P is its relatively high expression level. While it is easy to detect in many tissues, it is difficult to purify and to determine its function with high accuracy. This has limited the ability to study its role in specific processes. However, Dr. Li and his team have developed techniques to study ADGRE4P in live animals and to determine its function in pain perception and other physiological processes.

In addition to its potential drug target properties, ADGRE4P is also of interest as a biomarker for certain diseases. For example, it is often used as a marker for neurodegenerative diseases, as it is highly expressed in the brains of individuals with these diseases. It is also used as a marker for certain types of cancer, as it is often expressed in the tissues of individuals with these diseases.

Overall, ADGRE4P is a protein that is expressed in various tissues and cells in the body and is involved in a wide range of physiological processes. Its function is still being fully understood, and it is an attractive target for future research and drug development.

Protein Name: Adhesion G Protein-coupled Receptor E4, Pseudogene

Functions: May mediate the cellular interaction between myeloid cells and B-cells

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