Unlocking the Potential of ADH1A: A drug Target and Biomarker for Alcoholism

Target Name: ADH1A

NCBI ID: G124

Unlocking the Potential of ADH1A: A drug Target and Biomarker for Alcoholism

Introduction

Alcoholism is a significant public health issue worldwide, affecting millions of individuals and causing significant social, economic, and medical costs. The World Health Organization (WHO) estimates that alcohol-related deaths worldwide are around 2.5 million per year, with approximately 80% of those deaths occurring in low- and middle-income countries. The majority of these deaths are due to the overconsumption of alcohol, which can lead to a range of health problems, including liver disease, cardiovascular disease, and various cancers.

One of the major enzymes involved in the metabolism of alcohol is the alcohol dehydrogenase (ADH) subunit alpha (ADH1A). ADH1A is a key enzyme in the liver that converts alcohol to acetaldehyde, which is then converted to toxic intermediates that can cause harm to the body. Alcohol dehydrogenase (ADH) is a critical enzyme in the liver that converts alcohol to acetaldehyde, which is then converted to toxic intermediates that can cause harm to the body.

ADH1A is a transmembrane protein that is expressed in the liver, brain, and other tissues. It is composed of two subunits, A and B, which are held together by a disulfide bond. The A subunit contains the active site for the conversion of alcohol to acetaldehyde, while the B subunit contains a critical region that interacts with the A subunit.

The Importance of ADH1A in the metabolism of alcohol

ADH1A is a key enzyme that plays a crucial role in the metabolism of alcohol. It is responsible for the conversion of alcohol to acetaldehyde, which is then converted to toxic intermediates that can cause harm to the body. The production of these intermediates is what generates the toxic effects associated with alcohol consumption.

ADH1A is a critical enzyme that is expressed in the liver, brain, and other tissues. It is composed of two subunits, A and B, which are held together by a disulfide bond. The A subunit contains the active site for the conversion of alcohol to acetaldehyde, while the B subunit contains a critical region that interacts with the A subunit.

The role of ADH1A in the treatment of alcohol dependence

ADH1A is a drug target that has the potential to be a biomarker for alcohol dependence. Studies have shown that individuals with a history of alcohol dependence have lower levels of ADH1A than those without a history of alcohol dependence. This suggests that ADH1A may be a useful biomarker for identifying individuals at risk for alcohol dependence.

In addition, some studies have shown that individuals with a history of alcohol dependence have lower levels of ADH1A than those without a history of alcohol dependence. This suggests that ADH1A may be a useful target for developing interventions aimed at treating alcohol dependence.

The potential uses of ADH1A as a drug target

The potential uses of ADH1A as a drug target are vast. One of the most promising potential uses of ADH1A is as a treatment for alcohol dependence. Studies have shown that individuals with a history of alcohol dependence have lower levels of ADH1A than those without a history of alcohol dependence. This suggests that ADH1A may be a useful target for developing interventions aimed at treating alcohol dependence.

In addition, ADH1A may also be used as a biomarker for alcohol dependence. Studies have shown that individuals with a history of alcohol dependence have lower levels of ADH1A than those without a history of alcohol dependence. This suggests that ADH1A may be a useful biomarker for identifying individuals at risk for alcohol dependence.

The biochemical and clinical relevance of ADH1A

The biochemical and clinical relevance of ADH1A is vast. ADH1A is a transmembrane protein that is expressed in the liver, brain, and other tissues. It is composed of two subunits, A and B, which are held together by a disulfide bond. The

Protein Name: Alcohol Dehydrogenase 1A (class I), Alpha Polypeptide

Functions: Alcohol dehydrogenase (PubMed:2738060). Oxidizes primary as well as secondary alcohols. Ethanol is a very poor substrate (PubMed:2738060)

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