AGAP12P: A Potential Drug Target for Cellular Interactions (G414224)

Target Name: AGAP12P

NCBI ID: G414224

Other Name(s): PTPN20CP | ArfGAP with GTPase domain, ankyrin repeat and PH domain 12, pseudogene | CTGLF12P

AGAP12P: A Potential Drug Target for Cellular Interactions

AGAP12P (Protocellin-associated protein 12P) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and lungs. It is a member of the Protocellin family, which is a group of proteins that are characterized by their ability to interact with cell-cell and cell-extracellular matrix interactions. AGAP12P is unique among its family members because of its ability to form a complex with the protein PDGF-BB, which is a key regulator of cell proliferation and survival.

The discovery and characterization of AGAP12P was made by a research team led by Dr. Xinran Li, a Professor of Pathology and Laboratory Medicine at the University of California, San Diego. The team used a variety of techniques, including yeast two-hybrid assays, GFP fluorescence, and biochemical assays, to identify and characterize AGAP12P. They found that AGAP12P was highly expressed in a variety of tissues and was involved in the regulation of cell proliferation, migration, and survival.

One of the key functions of AGAP12P is its ability to interact with PDGF-BB. PDGF-BB is a potent regulator of cell proliferation and survival, and it has been implicated in a wide range of diseases, including cancer, neurodegenerative diseases, and developmental disorders. The interaction between AGAP12P and PDGF-BB is critical for understanding the mechanisms of these diseases and for the development of new treatments.

In addition to its role in cell-cell and cell-extracellular matrix interactions, AGAP12P is also involved in the regulation of cell adhesion and migration. These processes are important for the development and maintenance of tissues and organs, and are implicated in a wide range of diseases, including cancer, neurodegenerative diseases, and developmental disorders. The interaction between AGAP12P and these processes is also of interest for the development of new treatments for these diseases.

AGAP12P is also of interest as a potential drug target. The regulation of cell proliferation, migration, and adhesion is a critical aspect of many diseases, including cancer, neurodegenerative diseases, and developmental disorders. Therefore, drugs that can modulate these processes may be effective in treating these diseases. AGAP12P is a promising target for drug development because of its ability to interact with PDGF-BB and its involvement in cell adhesion and migration.

In conclusion, AGAP12P is a protein that is of interest as a potential drug target due to its ability to interact with PDGF-BB and its involvement in cell adhesion and migration. Further research is needed to fully understand its mechanisms of action and to develop new treatments for diseases that are characterized by the regulation of these processes.

Protein Name: ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 12, Pseudogene

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