AK4: An ATP-Driven GTPase for Genetic Information Transfer (G205)

Target Name: AK4

NCBI ID: G205

AK4: An ATP-Driven GTPase for Genetic Information Transfer

AK4 (GTP:AMP phosphotransferase), also known as ATP-dependent GTPase, is a protein that plays a crucial role in various cellular processes. It is an essential enzyme for the transfer of genetic information from the DNA to the RNA molecule during the process of transcription. AK4 is highly expressed in many tissues and is involved in various cellular processes, including DNA replication, transcription, and cell signaling. Its function is highly conserved across various species, making it an attractive target for drug development.

The protein encoded by the AK4 gene is a 26kDa protein that consists of a catalytic domain and a transmembrane region. The catalytic domain is responsible for the transfer of genetic information from GTP toAMP. The transmembrane region is responsible for the regulation of the activity of the enzyme and for its maintenance.

AK4 is involved in various cellular processes, including DNA replication, transcription, and cell signaling. During DNA replication, AK4 is responsible for the transfer of genetic information from the DNA template to the new DNA synthesized by the cell. It plays a critical role in the regulation of DNA replication timing, as well as the accuracy of DNA replication.

In addition to its role in DNA replication, AK4 is also involved in the regulation of gene expression. It has been shown to play a role in the regulation of various gene expression pathways, including cell signaling pathways. The transmembrane region of AK4 has been shown to be involved in the regulation of the activity of several intracellular signaling pathways, including the TOR signaling pathway.

AK4 is also involved in the regulation of cellular signaling pathways. It has been shown to play a role in the regulation of various signaling pathways, including the MAPK signaling pathway. The catalytic domain of AK4 is responsible for the transfer of genetic information from GTP toAMP, which is then used to regulate the activity of several intracellular signaling pathways.

Despite its importance in various cellular processes, AK4 is not well understood. There is limited research on the biology and chemistry of AK4, and its function in various cellular processes is not well characterized. As a result, it is an attractive target for drug development, as researchers can use it as a biomarker or drug candidate for various diseases.

In conclusion, AK4 is an essential enzyme for the transfer of genetic information from the DNA to the RNA molecule during the process of transcription. Its function is highly conserved across various species and makes it an attractive target for drug development. Further research is needed to fully understand the biology and chemistry of AK4 and its various cellular processes.

Protein Name: Adenylate Kinase 4

Functions: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates (PubMed:19073142, PubMed:19766732, PubMed:23416111, PubMed:24767988). Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor (PubMed:19073142, PubMed:19766732, PubMed:23416111). Also displays broad nucleoside diphosphate kinase activity (PubMed:19073142, PubMed:19766732, PubMed:23416111). Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK (PubMed:24767988, PubMed:26980435). Plays a protective role in the cellular response to oxidative stress (PubMed:19130895, PubMed:23474458, PubMed:26980435)

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