Aldehyde Dehydrogenase 3A2: Key Enzyme in Benzene Ring Metabolism

Target Name: ALDH3A2

NCBI ID: G224

Aldehyde Dehydrogenase 3A2: Key Enzyme in Benzene Ring Metabolism

Aldehyde dehydrogenase 3A2 (ALDH3A2) is a gene that encodes a protein known as ALDH3A2, which is a key enzyme involved in the metabolism of aromatic amines, such as those containing benzene rings. Benzene ring compounds are a class of compounds that widely exist in organisms and have a wide range of biological activities and pharmacological values. However, these compounds are often difficult to study and treat due to their complex biosynthetic and metabolic pathways. Therefore, studying the biological functions and metabolic pathways of ALDH3A2 is of great significance for in-depth understanding of the pharmacological value of these compounds.

Biological functions of ALDH3A2

ALDH3A2 is an important enzyme involved in the benzene ring oxidation reaction in the aromatic compound metabolism pathway. The benzene epoxidation reaction is an important step in the formation of aromatic epoxides from aromatic compounds. In this process, ALDH3A2 catalyzes the oxidation of a hydrogen atom on the benzene ring to a hydroxyl group, and is also responsible for oxidizing the carbonyl group on the benzene ring into a ketone carbonyl group. These reactions are necessary for aromatic compounds to form drug molecules.

ALDH3A2's role in drug discovery and development

Because ALDH3A2 plays a key role in aromatic compound metabolism pathways, it is a potential target in drug discovery and development. Many drug molecules contain benzene ring structures. Therefore, studying the function of ALDH3A2 can reveal the metabolic pathways of benzene ring structures in drug molecules and provide new ideas for drug design and development. In addition, studying the metabolic pathway of ALDH3A2 may also provide important clues to the efficacy and toxic side effects of drugs.

Metabolic pathways of ALDH3A2

Metabolism of ALDH3A2 occurs primarily in the liver and kidneys. In the liver, ALDH3A2 is mainly metabolized in the cytoplasm and then excreted through the blood circulation system. In the kidneys, ALDH3A2 is primarily excreted in the urine. Metabolites are mainly excreted through the liver and kidneys, so studying the metabolic pathways of ALDH3A2 is of great significance for studying the excretion mechanism of drugs in the body.

Pharmacological value of ALDH3A2

ALDH3A2 is a very promising drug target because of its important role in drug discovery and development. Many drug molecules contain benzene ring structures. Therefore, studying the function of ALDH3A2 can reveal the metabolic pathways of benzene ring structures in these drug molecules and provide new ideas for drug design and development. In addition, studying the metabolic pathway of ALDH3A2 may also provide important clues to the efficacy and toxic side effects of drugs.

in conclusion

ALDH3A2 is an important enzyme involved in the benzene ring oxidation reaction in the metabolic pathway of aromatic compounds. These reactions are necessary for the formation of aromatic ring structures in drug molecules. Therefore, studying the biological functions and metabolic pathways of ALDH3A2 is of great significance for drug discovery and development.

Protein Name: Aldehyde Dehydrogenase 3 Family Member A2

Functions: Catalyzes the oxidation of medium and long chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length (PubMed:9133646, PubMed:22633490, PubMed:25047030, PubMed:18035827, PubMed:9662422, PubMed:18182499). Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid (PubMed:22633490)

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