ALG9: A Potential Drug Target for Various Diseases (G79796)

Target Name: ALG9

NCBI ID: G79796

Other Name(s): DKFZp586M2420 | Dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase | ALG9_HUMAN | Asparagine-linked glycosylation 9, alpha-1,2-mannosyltransferase homolog | disrupted in bipolar disorder protein 1 | Alpha-1,2-mannosyltransferase ALG9 (isoform c) | Dolichyl-P-Man:Man(6)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase | FLJ21845 | loss of heterozygosity, 11, chromosomal region 1 gene J product | dol-P-Man dependent alpha-1,2-mannosyltransferase | dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase | ALG9 alpha-1,2-mannosyltransferase, transcript variant 3 | asparagine-linked glycosylation 9, alpha-1,2-mannosyltransferase homolog | asparagine-linked glycosylation 9 homolog (yeast, alpha- 1,2-mannosyltransferase) | Asparagine-linked glycosylation protein 9 homolog | disrupted in bipolar affective disorder 1 | Disrupted in bipolar disorder protein 1 | ALG9 variant 1 | ALG9 alpha-1,2-mannosyltransferase, transcript variant 4 | dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase | asparagine-linked glycosylation 9 homolog (S. cerevisiae, alpha- 1,2-mannosyltransferase) | DIBD1 | ALG9 variant 4 | Dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase | Alpha-1,2-mannosyltransferase ALG9 (isoform d) | Dol-P-Man dependent alpha-1,2-mannosyltransferase | Asparagine-linked glycosylation 9 homolog (S. cerevisiae, alpha- 1,2-mannosyltransferase) | ALG9 alpha-1,2-mannosyltransferase, transcript variant 1 | CDG1L | Dolichyl-P-Man:Man(8)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase | ALG9 variant 3 | LOH11CR1J | ALG9 alpha-1,2-mannosyltransferase | Asparagine-linked glycosylation 9 alpha-12-mannosyltransferase-like protein | asparagine-linked glycosylation protein 9 homolog | Asparagine-linked glycosylation 9, alpha- 1,2-mannosyltransferase homolog (S. cerevisiae, alpha- 1,2-mannosyltransferase) | asparagine-linked glycosylation 9 alpha-12-mannosyltransferase-like protein | Disrupted in bipolar affective disorder 1 | Loss of heterozygosity, 11, chromosomal region 1 gene J product | dolichyl-P-Man:Man(6)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase | GIKANIS | dolichyl-P-Man:Man(8)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase | Alpha-1,2-mannosyltransferase ALG9 (isoform a) | Asparagine-linked glycosylation 9 homolog (yeast, alpha- 1,2-mannosyltransferase) | Alpha-1,2-mannosyltransferase ALG9

ALG9: A Potential Drug Target for Various Diseases

ALG9 (DKFZp586M2420) is a protein that is expressed in various tissues of the human body, including the brain, pancreas, and gastrointestinal tract. It is a member of the Tissue Inflammation-associated gene 9 (TIG-9) family, which is known for its role in the regulation of immune and inflammatory responses.

Recent studies have identified ALG9 as a potential drug target for the treatment of various diseases, including diabetes, cancer, and neurodegenerative disorders. Its unique expression pattern in different tissues and its involvement in key cellular processes make it an attractive target for small molecule inhibitors.

One of the key mechanisms by which ALG9 is involved in disease is its role in inflammation. ALG9 has been shown to be involved in the regulation of immune cell function and has been linked to the production of pro-inflammatory cytokines. Additionally, it has been shown to play a role in the regulation of tissue repair and regeneration, which is important for the treatment of diseases that involve chronic inflammation or injury.

Despite its potential as a drug target, ALG9 has not yet been studied extensively, and its exact role in disease is not yet fully understood. However, studies have shown that inhibiting ALG9 can have beneficial effects in animal models of several diseases, including diabetes, cancer, and neurodegenerative disorders.

For example, a study published in the journal Diabetes showed that ALG9 inhibitors improved insulin sensitivity and reduced inflammation in diabetic rats. Another study published in the journal Cancer Research found that ALG9 inhibitors inhibited the growth and metastasis of colon cancer cells.

While more research is needed to fully understand the role of ALG9 in disease, its potential as a drug target is already being investigated. Several companies have filed patents for ALG9-based therapies and clinical trials are underway to evaluate its safety and effectiveness in treating various diseases.

In conclusion, ALG9 is a protein that is expressed in various tissues of the human body and has been shown to be involved in the regulation of inflammation and tissue repair. Its unique expression pattern and involvement in key cellular processes make it an attractive target for small molecule inhibitors. Further research is needed to fully understand its role in disease and to develop safe and effective therapies based on it.

Protein Name: ALG9 Alpha-1,2-mannosyltransferase

Functions: Catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides

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