AMBP as a Drug Target: Unlocking the Potential of Protein AMBP

Target Name: AMBP

NCBI ID: G259

AMBP as a Drug Target: Unlocking the Potential of Protein AMBP

AMBP (AMyloid-Beta Plasma Protein) is a protein that is expressed in high levels in the blood plasma of individuals with Alzheimer's disease (AD). It is a potential drug target and biomarker for the disease, which has a significant impact on the lives of millions of people worldwide. In this article, we will explore the potential of AMBP as a drug target and biomarker in the context of Alzheimer's disease.

AMBP as a Drug Target

AMBP has been identified as a potential drug target due to its unique structure and its ability to interact with various molecules. AMBP is a transmembrane protein that consists of four regions: a N-terminus, a T-terminus, a middle region, and an C-terminus. It has a calculated molecular weight of 18 kDa and a calculated pI of 9.6. AMBP is highly conserved and has been shown to have similar structures in various species, including humans.

One of the key features that makes AMBP a promising drug target is its ability to interact with various proteins, including beta-amyloid peptides. Beta-amyloid peptides are a hallmark of AD and have been shown to contribute to the development and progression of the disease.AMBP has been shown to interact with beta-amyloid peptides, which may explain its potential as a drug target.

AMBP as a Biomarker

AMBP has also been identified as a potential biomarker for AD. The use of AMBP as a biomarker may have several advantages over other biomarkers, such as ease of collection and high sensitivity.AMBP is a protein that is expressed in high levels in the blood plasma of individuals with Alzheimer's disease, making it a potential biomarker for the disease.

AMBP has been shown to have decreased levels in individuals with AD compared to age-matched individuals. This suggests that AMBP may be a useful biomarker for the disease. Additionally, AMBP has been shown to have a correlation with the levels of beta-amyloid peptides in the brain, which may further support its use as a biomarker for AD.

Conclusion

AMBP is a protein that has potential as a drug target and biomarker for Alzheimer's disease. Its unique structure and ability to interact with various molecules make it a promising candidate for drug development. Further research is needed to fully understand the potential of AMBP as a drug target and biomarker for AD.

Protein Name: Alpha-1-microglobulin/bikunin Precursor

Functions: Antioxidant and tissue repair protein with reductase, heme-binding and radical-scavenging activities. Removes and protects against harmful oxidants and repairs macromolecules in intravascular and extravascular spaces and in intracellular compartments (PubMed:11877257, PubMed:15683711, PubMed:22096585, PubMed:23157686, PubMed:23642167, PubMed:25698971, PubMed:32823731, PubMed:32092412). Intravascularly, plays a regulatory role in red cell homeostasis by preventing heme- and reactive oxygen species-induced cell damage. Binds and degrades free heme to protect fetal and adult red blood cells from hemolysis (PubMed:11877257, PubMed:32092412). Reduces extracellular methemoglobin, a Fe3+ (ferric) form of hemoglobin that cannot bind oxygen, back to the Fe2+ (ferrous) form deoxyhemoglobin, which has oxygen-carrying potential (PubMed:15683711). Upon acute inflammation, inhibits oxidation of low-density lipoprotein particles by MPO and limits vascular damage (PubMed:25698971). Extravascularly, protects from oxidation products formed on extracellular matrix structures and cell membranes. Catalyzes the reduction of carbonyl groups on oxidized collagen fibers and preserves cellular and extracellular matrix ultrastructures (PubMed:23642167, PubMed:22096585). Importantly, counteracts the oxidative damage at blood-placenta interface, preventing leakage of free fetal hemoglobin into the maternal circulation (PubMed:21356557). Intracellularly, has a role in maintaining mitochondrial redox homeostasis. Bound to complex I of the respiratory chain of mitochondria, may scavenge free radicals and preserve mitochondrial ATP synthesis. Protects renal tubule epithelial cells from heme-induced oxidative damage to mitochondria (PubMed:23157686, PubMed:32823731). Reduces cytochrome c from Fe3+ (ferric) to the Fe2+ (ferrous) state through formation of superoxide anion radicals in the presence of ascorbate or NADH/NADPH electron donor cofactors, ascorbate being the preferred cofactor (PubMed:15683711). Has a chaperone role in facilitating the correct folding of bikunin in the endoplasmic reticulum compartment (By similarity)

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