ANGPT4: A Potential Drug Target and Biomarker for Diseases (G51378)

Target Name: ANGPT4

NCBI ID: G51378

Other Name(s): Angiopoietin-4 | Angiopoietin 4, transcript variant 1 | MGC138181 | ANG3 | angiopoietin 4 | ANGPT4 variant 1 | MGC138183 | AGP4 | ANG-4 | ANGP4_HUMAN | Angiopoietin-3 | ANG4 | ANG-3 | dJ824F16.2 (angiopoietin 4) | Angiopoietin-4 (isoform 1)

ANGPT4: A Potential Drug Target and Biomarker for Diseases

Angiopoietin-4 (ANGPT4) is a protein that is expressed in the endothelial cells of the body. It is a potent vasoactive protein that plays a critical role in the regulation of blood flow to the body's tissues. ANGPT4 has been shown to be involved in the development and maintenance of various diseases, including cardiovascular disease, cancer, and neurodegenerative diseases. As a result, ANGPT4 has emerged as a promising drug target and biomarker for a variety of diseases.

The ANGPT4 protein is composed of 256 amino acids and has a molecular weight of 31.1 kDa. It is expressed in the endothelial cells of the body, including the blood vessels, heart, and kidneys. ANGPT4 is a potent vasoactive protein that causes blood vessels to constrict and relax in response to different stimuli. This allows it to regulate blood flow to the body's tissues and is essential for maintaining the health and function of the endothelial cells.

Several studies have shown that ANGPT4 is involved in the development and maintenance of various diseases. For example, ANGPT4 has been shown to be involved in the development of cardiovascular disease. Studies have shown that ANGPT4 levels are elevated in the endothelial cells of patients with cardiovascular disease, and that it promotes the growth and survival of these cells. This suggests that ANGPT4 may be a useful drug target for cardiovascular disease.

ANGPT4 has also been shown to be involved in the development and progression of cancer. Many studies have shown that ANGPT4 is expressed in various types of cancer, including breast, lung, and colorectal cancer. Additionally, ANGPT4 has been shown to promote the growth and survival of cancer cells. This suggests that ANGPT4 may be a useful biomarker for cancer and that it may be a potential drug target.

ANGPT4 has also been shown to be involved in the development and progression of neurodegenerative diseases. Many studies have shown that ANGPT4 is expressed in various types of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. Additionally, ANGPT4 has been shown to promote the growth and survival of neurodegenerative disease cells. This suggests that ANGPT4 may be a useful drug target for neurodegenerative diseases.

In addition to its involvement in the development and progression of diseases, ANGPT4 has also been shown to have potential therapeutic applications. For example, ANGPT4 has been shown to have anti-inflammatory effects. This suggests that ANGPT4 may be a useful target for the treatment of inflammatory diseases. Additionally, ANGPT4 has been shown to have anti-cancer effects. This suggests that ANGPT4 may be a useful target for the treatment of cancer.

Overall, ANGPT4 is a protein that is involved in the regulation of blood flow to the body's tissues and has been shown to be involved in the development and maintenance of various diseases. As a result, ANGPT4 has emerged as a promising drug target and biomarker for a variety of diseases. Further research is needed to fully understand the role of ANGPT4 in the regulation of blood flow and the development and progression of disease. However, the potential therapeutic applications of ANGPT4 make it a valuable tool for the development of new treatments for a variety of diseases.

Protein Name: Angiopoietin 4

Functions: Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis

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