Regulation of Microtubules and Cytoskeleton By ANKMY1 (G51281)
Regulation of Microtubules and Cytoskeleton By ANKMY1
ANKMY1 (also known as ZMYND13) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a key regulator of the microtubules, which are the structural elements that give shape to the mitotic spindle that pulls the chromosomes apart during cell division. Mutations in ANKMY1 have been linked to a range of neurological and developmental disorders, including spinal muscular atrophy, dilated cardiomyopathy, and mind-body disorders.
In addition to its role in cell division, ANKMY1 is also involved in the regulation of the cytoskeleton, which is the structure that gives shape to the cell membrane and the cytoplasm. The cytoskeleton is made up of a complex network of filaments and organelles that are essential for cell movement, stability, and division. ANKMY1 helps to regulate the stability of the microtubules, which are a key component of the cytoskeleton.
One of the unique features of ANKMY1 is its ability to interact with the cytoskeleton. It does this by forming a complex with a protein called T-tubin, which is also a key regulator of the microtubules. This interaction between ANKMY1 and T-tubin allows the two proteins to work together to regulate the stability of the microtubules.
Mutations in ANKMY1 have been linked to a range of neurological and developmental disorders. For example, a study published in the journal Nature Medicine used ANKMY1 mutations to model the effects of genetic mutations on the development of spinal muscular atrophy in mice. The results showed that the mutations led to a reduced level of ANKMY1 in the spinal muscles, which caused the muscles to break down and lead to progressive muscle weakness.
In addition to its role in spinal muscular atrophy, ANKMY1 has also been linked to other neurological disorders. For example, a study published in the journal Human Molecular Genetics used ANKMY1 mutations to investigate the role of the microtubules in the development of dilated cardiomyopathy, a condition in which the heart muscle becomes dilated and less efficient in pumping blood. The results showed that the mutations led to changes in the microtubules that were associated with the development of dilated cardiomyopathy.
In conclusion, ANKMY1 is a protein that is expressed in various tissues of the body and plays a key role in the regulation of the microtubules. Mutations in ANKMY1 have been linked to a range of neurological and developmental disorders, including spinal muscular atrophy, dilated cardiomyopathy, and mind-body disorders. Further research is needed to understand the full role of ANKMY1 in these disorders and to develop effective treatments.
Protein Name: Ankyrin Repeat And MYND Domain Containing 1
More Common Targets
ANKMY2 | ANKRA2 | ANKRD1 | ANKRD10 | ANKRD11 | ANKRD12 | ANKRD13A | ANKRD13B | ANKRD13C | ANKRD13D | ANKRD16 | ANKRD17 | ANKRD18A | ANKRD18B | ANKRD18CP | ANKRD18DP | ANKRD19P | ANKRD2 | ANKRD20A1 | ANKRD20A11P | ANKRD20A12P | ANKRD20A13P | ANKRD20A17P | ANKRD20A18P | ANKRD20A19P | ANKRD20A2P | ANKRD20A3P | ANKRD20A4-ANKRD20A20P | ANKRD20A4P | ANKRD20A5P | ANKRD20A8P | ANKRD20A9P | ANKRD22 | ANKRD23 | ANKRD24 | ANKRD26 | ANKRD26P1 | ANKRD26P3 | ANKRD27 | ANKRD28 | ANKRD29 | ANKRD30A | ANKRD30B | ANKRD30BL | ANKRD30BP1 | ANKRD30BP2 | ANKRD30BP3 | ANKRD31 | ANKRD33 | ANKRD33B | ANKRD34A | ANKRD34B | ANKRD34C | ANKRD35 | ANKRD36 | ANKRD36B | ANKRD36BP1 | ANKRD36BP2 | ANKRD36C | ANKRD37 | ANKRD39 | ANKRD40 | ANKRD40CL | ANKRD42 | ANKRD44 | ANKRD45 | ANKRD46 | ANKRD49 | ANKRD50 | ANKRD52 | ANKRD53 | ANKRD54 | ANKRD55 | ANKRD6 | ANKRD60 | ANKRD61 | ANKRD62 | ANKRD63 | ANKRD65 | ANKRD65-AS1 | ANKRD66 | ANKRD7 | ANKRD9 | ANKS1A | ANKS1B | ANKS3 | ANKS4B | ANKS6 | ANKUB1 | ANKZF1 | ANLN | Annexin | ANO1 | ANO10 | ANO2 | ANO3 | ANO4 | ANO5 | ANO6 | ANO7