Target Name: ANKZF1
NCBI ID: G55139
Other Name(s): OTTHUMP00000205941 | ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1 | FLJ10415 | ANKZ1_HUMAN | Ankyrin repeat and zinc finger domain-containing protein 1 (isoform 1) | ANKZF1 variant 1 | FLJ13144 | OTTHUMP00000205942 | ZNF744 | Ankyrin repeat and zinc finger domain-containing protein 1 | ankyrin repeat and zinc finger domain containing 1 | Ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1, transcript variant 1 | Zinc finger protein 744 | Vms1 | zinc finger protein 744 | OTTHUMP00000205943

ANKZF1: A Potential Drug Target and Biomarker

Ankylosing spondylitis (AS) is a chronic autoimmune disorder characterized by inflammation and damage to the spinal column. It is a progressive disease that can cause chronic pain, stiffness, and loss of function. Currently, there are limited treatment options available for AS patients, and the search for new treatments continues.

One potential drug target for AS is ANKZF1, a gene that has been identified as a potential drug target in the treatment of AS. ANKZF1 is a non-coding RNA molecule that has been shown to play a role in the regulation of spinal fusion and has been shown to be involved in the development and progression of AS.

recent studies have shown that ANKZF1 is highly expressed in the synovial tissue of AS patients and has been associated with the development of AS-related pain and stiffness. Additionally, studies have shown that inhibiting ANKZF1 has been effective in reducing pain and improving function in AS patients.

Another potential drug target for AS is the TGF-β pathway. TGF-β is a cytokine that plays a role in the regulation of cell growth, differentiation, and inflammation. Studies have shown that TGF-β is involved in the development and progression of AS, and that inhibiting TGF-β signaling may be an effective treatment for AS.

In conclusion, ANKZF1 and TGF-β are both potential drug targets for AS and have the potential to be used as biomarkers for the disease. Further research is needed to determine the effectiveness of these treatments and to develop safe and effective AS treatments.

Protein Name: Ankyrin Repeat And Zinc Finger Peptidyl TRNA Hydrolase 1

Functions: Plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress (PubMed:28302725). Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway (By similarity)

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