Ankler 2: A Potential Drug Target and Biomarker for Various Diseases

Target Name: ANKLE2

NCBI ID: G23141

Ankler 2: A Potential Drug Target and Biomarker for Various Diseases

ANKLE2 (MCPH16) is a gene that has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. The ANKLE2 gene is located on chromosome 16 and encodes a protein known as ANKLE2, which is a key regulator of the T-cell receptor (TCR), a critical protein that helps coordinate immune responses.

In cancer, ANKLE2 has been shown to be involved in the regulation of cell growth, apoptosis (programmed cell death), and immune surveillance. It has also been implicated in the development of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, as well as autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis.

One of the key challenges in studying ANKLE2 is its complex function and its involvement in multiple biological processes. However, research into ANKLE2 has identified several potential drug targets and biomarkers that may be useful in the development of new treatments for these diseases.

One of the most promising potential drug targets for ANKLE2 is the use of small molecules, such as drugs that can modulate the activity of ANKLE2. These molecules have been shown to be effective in preclinical studies for treating a variety of diseases, including cancer, neurodegenerative disorders, and autoimmune diseases.

Another potential drug target for ANKLE2 is the use of antibodies, such as monoclonal antibodies (MCAs), that can target specific regions of ANKLE2 and enhance the activity of other immune cells. These antibodies have been shown to be effective in preclinical studies for treating a variety of diseases, including cancer and autoimmune disorders.

In addition to drug targets and antibodies, ANKLE2 has also been identified as a potential biomarker for a variety of diseases. For example, ANKLE2 has been shown to be expressed in a variety of tissues and cells, including immune cells, neurons, and glial cells, which may make it an attractive target for diagnostic tests.

Another potential application of ANKLE2 is its role in the regulation of T-cell development and function. ANKLE2 has been shown to play a key role in the development and maturation of T-cells, which are a critical part of the immune system. Additionally, ANKLE2 has been shown to regulate the activity of T-cells, including their ability to recognize and respond to foreign antigens.

In conclusion, ANKLE2 is a gene that has been identified as a potential drug target and biomarker for a variety of diseases. Its complex function and involvement in multiple biological processes make it an attractive target for research into new treatments for a variety of diseases. While further research is needed to fully understand the role of ANKLE2 in these diseases, its potential as a drug target and biomarker is an exciting area of research that may lead to new treatments for a variety of diseases.

Protein Name: Ankyrin Repeat And LEM Domain Containing 2

Functions: Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit (PubMed:22770216). Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly (PubMed:22770216). May regulate nuclear localization of VRK1 in non-dividing cells (PubMed:31735666). It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex (PubMed:22770216). Involved in brain development (PubMed:25259927)

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