ANAPC13: A Potential Drug Target and Biomarker (G25847)

Target Name: ANAPC13

NCBI ID: G25847

ANAPC13: A Potential Drug Target and Biomarker

Anaphase promoting complex subunit 13 (ANAPC13) is a protein that plays a critical role in the regulation of cell division. It is a key component of the microtubule spindle system, which is responsible for transporting the replicated chromosomes to the opposite ends of the cell during mitosis. ANAPC13 has been identified as a potential drug target and biomarker due to its unique structure and its involvement in the control of cell division.

ANAPC13 is a 21-kDa protein that is expressed in a variety of tissues, including brain, heart, and muscle. It is composed of two unique domains: a N-terminal transmembrane domain and a C-terminal protein domain. The N-terminal transmembrane domain is responsible for the protein's ability to interact with the cytoskeleton and the C-terminal protein domain is responsible for the protein's unique structure and its involvement in the regulation of cell division.

One of the key features of ANAPC13 is its ability to interact with the cytoskeleton. It does this by forming a complex with the protein tyrosine kinase (TK), which is a key regulator of the cytoskeleton. This interaction between ANAPC13 and TK allows the protein to regulate the level of microtubules in the cell, which are important for the transport of replicated chromosomes to the opposite ends of the cell during mitosis.

ANAPC13's involvement in the regulation of cell division has led to its potential as a drug target. One of the main advantages of ANAPC13 as a drug target is its unique structure, which allows for the development of specific and effective inhibitors. Additionally, ANAPC13's involvement in the regulation of cell division makes it an attractive biomarker for the diagnosis and treatment of various diseases, such as cancer.

ANAPC13 has also been shown to play a role in the regulation of cell migration and the formation of tissues. Its ability to interact with the cytoskeleton and regulate the level of microtubules in the cell makes it a potential target for the development of new therapies for a variety of diseases, including cancer, neurodegenerative diseases, and developmental disorders.

In conclusion, ANAPC13 is a protein that has the potential to be a drug target and biomarker due to its unique structure and its involvement in the regulation of cell division. Further research is needed to fully understand the role of ANAPC13 in the regulation of cell division. and its potential as a drug target and biomarker.

Protein Name: Anaphase Promoting Complex Subunit 13

Functions: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains

More Common Targets