ANGPT2: A Potential Drug Target for Cardiovascular Disease (G285)

Target Name: ANGPT2

NCBI ID: G285

ANGPT2: A Potential Drug Target for Cardiovascular Disease

Angiopoietin-2a (ANGPT2) is a protein that is expressed in the endothelial cells of the body. It is a potent vasoactive protein that plays a critical role in the regulation of blood flow and is often referred to as an endothelial-secreted protein (ESP). ANGPT2 is expressed in a variety of tissues throughout the body, including the heart, lungs, kidneys, and liver. It is a potential drug target (or biomarker) due to its unique structure and function.

The ANGPT2 protein is made up of 218 amino acids and has a calculated molecular weight of 23.9 kDa. It is a single transmembrane protein that is expressed in the endothelial cells of the body. The endothelial cells are responsible for maintaining the integrity of the blood vessels and play a critical role in the regulation of blood flow. ANGPT2 is involved in the regulation of several physiological processes that are essential for the maintenance of cardiovascular health, including blood pressure, blood flow, and the formation of new blood vessels.

One of the key functions of ANGPT2 is its ability to regulate the diameter of blood vessels. Angiopoietin-2a has been shown to cause blood vessels to constrict, which can improve blood flow to the body's tissues. This is important for maintaining oxygen and nutrient delivery to the cells that need them. ANGPT2 has also been shown to cause blood vessels to relax, which can help to reduce blood pressure and protect against cardiovascular disease.

ANGPT2 is also involved in the regulation of the growth and proliferation of endothelial cells. Endothelial cells are special cells that line the blood vessels and play a critical role in maintaining the integrity of the blood vessels. ANGPT2 is shown to be involved in the regulation of endothelial cell growth and proliferation, which is important for the formation of new blood vessels and the maintenance of cardiovascular health.

ANGPT2 is also involved in the regulation of the immune response. Endothelial cells are a critical target for immune cells, and ANGPT2 is shown to be involved in the regulation of the immune response. This is important for maintaining the integrity of the immune system and protecting the body against infection.

In conclusion, ANGPT2 is a protein that is expressed in the endothelial cells of the body and is involved in several critical physiological processes that are essential for maintaining cardiovascular health. As a potential drug target (or biomarker), ANGPT2 is a promising target for the development of new treatments for cardiovascular disease. Further research is needed to fully understand the functions of ANGPT2 and its potential as a drug.

Protein Name: Angiopoietin 2

Functions: Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling (PubMed:15284220, PubMed:19116766, PubMed:19223473, PubMed:9204896). Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1 (PubMed:15284220, PubMed:19116766, PubMed:19223473, PubMed:9204896). In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (PubMed:15284220, PubMed:19116766, PubMed:19223473, PubMed:9204896). Involved in the regulation of lymphangiogenesis (PubMed:32908006)

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