Stable DNA Binding and Gene Regulation: ALOX15 in Cancer (G246)

Target Name: ALOX15

NCBI ID: G246

Stable DNA Binding and Gene Regulation: ALOX15 in Cancer

ALOX15 (LOX15_HUMAN) is a protein that is expressed in various tissues of the human body, including the brain, heart, liver, and pancreas. It is a member of the superfamily of DNA-binding proteins, known as the homeodetic transcription factor subfamily 15 (HDFN). HDFN proteins are known for their ability to interact with DNA and regulate gene expression.

One of the unique features of ALOX15 is its ability to form a stable complex with DNA in the nucleus. This interaction between the protein and DNA has important implications for the function of the protein. The protein is known to play a role in regulating gene expression and has been shown to interact with several different DNA-binding proteins, including the transcription factor ASXL1.

In addition to its role in gene regulation, ALOX15 is also known for its role in the development and progression of several diseases, including cancer. Studies have shown that ALOX15 is overexpressed in several types of cancer, including breast, ovarian, and colorectal cancer. This overexpression is thought to contribute to the development and progression of these diseases.

Furthermore, ALOX15 has also been shown to be a potential drug target in cancer treatment. Several studies have shown that inhibiting the activity of ALOX15 can lead to a reduction in the growth and spread of cancer cells. This suggests that ALOX15 may be a useful target for cancer therapy.

In addition to its potential as a drug target, ALOX15 is also an important biomarker for cancer. The protein is often used as a diagnostic marker for cancer, as its expression is often increased in the brains and other tissues of cancer patients. This makes ALOX15 a potentially useful biomarker for cancer diagnosis and monitoring.

Overall, ALOX15 is a protein that has important implications for the development and progression of cancer. Its ability to form a stable complex with DNA in the nucleus and its role in gene regulation make it an attractive target for drug development. Furthermore, its potential as a biomarker for cancer makes it an important tool for cancer diagnosis and monitoring.

Protein Name: Arachidonate 15-lipoxygenase

Functions: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators (PubMed:1944593, PubMed:8334154, PubMed:17052953, PubMed:24282679, PubMed:25293588, PubMed:32404334). It inserts peroxyl groups at C12 or C15 of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) producing both 12-hydroperoxyeicosatetraenoate/12-HPETE and 15-hydroperoxyeicosatetraenoate/15-HPETE (PubMed:1944593, PubMed:8334154, PubMed:17052953, PubMed:24282679). It may then act on 12-HPETE to produce hepoxilins, which may show pro-inflammatory properties (By similarity). Can also peroxidize linoleate ((9Z,12Z)-octadecadienoate) to 13-hydroperoxyoctadecadienoate/13-HPODE (PubMed:8334154). May participate in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs)like resolvin D5 ((7S,17S)-diHPDHA) and (7S,14S)-diHPDHA, that actively down-regulate the immune response and have anti-aggregation properties with platelets (PubMed:32404334). Can convert epoxy fatty acids to hydroperoxy-epoxides derivatives followed by an intramolecular nucleophilic substitution leading to the formation of monocyclic endoperoxides (PubMed:25293588). Plays an important role during the maintenance of self-tolerance by peroxidizing membrane-bound phosphatidylethanolamine which can then signal the sorting process for clearance of apoptotic cells during inflammation and prevent an autoimmune response. In addition to its role in the immune and inflammatory responses, this enzyme may play a role in epithelial wound healing in the cornea through production of lipoxin A4 (LXA(4)) and docosahexaenoic acid-derived neuroprotectin D1 (NPD1; 10R,17S-HDHA), both lipid autacoids exhibit anti-inflammatory and neuroprotective properties. Furthermore, it may regulate actin polymerization which is crucial for several biological processes such as the phagocytosis of apoptotic cells. It is also implicated in the generation of endogenous ligands for peroxisome proliferator activated receptor (PPAR-gamma), hence modulating macrophage development and function. It may also exert a negative effect on skeletal development by regulating bone mass through this pathway. As well as participates in ER stress and downstream inflammation in adipocytes, pancreatic islets, and liver (By similarity). Finally, it is also involved in the cellular response to IL13/interleukin-13 (PubMed:21831839)

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