ALG2: Key Player in Manosylated Protein Biosynthesis and Cellular Processes

Target Name: ALG2

NCBI ID: G85365

Other Name(s): GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase | Glycolipid 3-?-mannosyltransferase | CDGIi | ALG2_HUMAN | Asparagine-linked glycosylation 2 homolog (S. cerevisiae, alpha-1,3-mannosyltransferase) | Asparagine-linked glycosylation 2 homolog (yeast, alpha-1,3-mannosyltransferase) | CMSTA3 | FLJ14511 | ALG2 alpha-1,3/1,6-mannosyltransferase, transcript variant 1 | Alg2 mannosyltransferase (ambiguous) | ALG2 alpha-1,3/1,6-mannosyltransferase | asparagine-linked glycosylation 2 homolog (S. cerevisiae, alpha-1,3-mannosyltransferase) | CMS14 | GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase | GDP-Man:Man1GlcNAc2-PP-dolichol mannosyltransferase (ambiguous) | Homolog of yeast ALG2 | asparagine-linked glycosylation protein 2 homolog | Asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog | homolog of yeast ALG2 | Alpha-1,3/1,6-mannosyltransferase ALG2 | CDG1I | ALG2 (gene name, ambiguous) | ALG2 variant 1 | GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase | GDP-Man:Man2GlcNAc2-PP-Dol alpha-1,6-mannosyltransferase | GDP-Man:Man1GlcNAc2-PP-Dol ?-1,3-mannosyltransferase | GDP-mannose:glycolipid 3-?-D-mannosyltransferase | alpha-1,3-mannosyltransferase ALG2 | asparagine-linked glycosylation 2 homolog (yeast, alpha-1,3-mannosyltransferase) | asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog | Asparagine-linked glycosylation protein 2 homolog | NET38 | Alpha-1,3-mannosyltransferase ALG2 | hALPG2

ALG2: Key Player in Manosylated Protein Biosynthesis and Cellular Processes

ALG2 (GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase) is a protein that is expressed in various tissues and cells in the human body. It is a key player in the biosynthesis of mannosylated proteins, which are involved in various cellular processes. Despite its importance, little is known about ALG2 and its potential role in human health.

The ALG2 protein is a member of the HOMER family of proteins, which are involved in the transfer of chemical groups, such as mannosyl groups, to target proteins. HOMER proteins have been implicated in various cellular processes, including cell signaling, metabolism, and inflammation.

One of the unique aspects of ALG2 is its role in the biosynthesis of mannosylated proteins. Mannosylated proteins are involved in various cellular processes, including cell signaling, inflammation, and metabolism. They are also involved in the development and progression of various diseases, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis.

ALG2 is expressed in various tissues and cells in the human body, including the brain, pancreas, and gastrointestinal tract. It is also involved in the biosynthesis of various mannosylated proteins, including GLUT1 (GDP-Man:GlcNAc(2)-PP-dolichol mannosyltransferase), GLUT2 (GDP-Man:GlcNAc(2)-PP-dolichol mannosyltransferase), and GLUT3 (GDP-Man:GlcNAc(2)-PP-dolichol mannosyltransferase).

GLUT1 is involved in the biosynthesis of glutamic acid, which is a key ingredient in many neurotransmitters, including serotonin and dopamine. GLUT2 is involved in the biosynthesis of GABA, which is a neurotransmitter that is involved in cell signaling and metabolism. GLUT3 is involved in the biosynthesis of hyaluronic acid, which is a component of connective tissue extracellular matrix.

The role of ALG2 in the biosynthesis of mannosylated proteins is still being studied. However, it is known that ALG2 plays a key role in the regulation of mannosylation. Mammalian ALG2 is involved in the regulation of GLUT1, GLUT2, and GLUT3 mannosylation, and it is thought to do so by interacting with the corresponding protein tyrosines.

ALG2 has also been shown to be involved in the regulation of cellular processes, including cell signaling, metabolism, and inflammation. For example, ALG2 has been shown to be involved in the regulation of cell proliferation, cell migration, and the production of various signaling molecules, such as actinin and vasopressin.

In conclusion, ALG2 is a protein that is involved in the biosynthesis of mannosylated proteins and the regulation of various cellular processes. Its role in these processes is still being studied, but it is clear that ALG2 is a potential drug target and biomarker for various diseases. Further research is needed to fully understand the role of ALG2 in human health and to develop effective treatments for these diseases.

Protein Name: ALG2 Alpha-1,3/1,6-mannosyltransferase

Functions: Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate

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